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Fluorinated Fructose Derivatives for PET Imaging

University of Alberta

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RECOMBINANT CARDIOMYOCYTES AND CARDIOMYOCYTE CELL LINES EXPRESSING HERG

University of Alberta

The present disclosure relates generally to recombinant cardiomyocytes and cardiomyocyte cell lines overexpressing hERG and uses thereof.

HIGHLY PARALLEL ASSAYS FOR SIMULTANEOUS IDENTIFICATION OF ANTIBODY SEQUENCES AND BINDING PARTNERS

University of British Columbia

The present invention relates to methods for isolating the sequences of an antibody that reacts with a disease related antigen, e.g., an autoantigen, without knowing the identity of the antigen (sequence or structural epitope) a priori. The methods can also be used to identify an antigen that mediates a disease state, e.g., an autoantigen implicated in an autoimmune disorder or a tumor response.

Pharmacological chaperones for treating obesity

Amicus Therapeutics, University of Montreal

The invention relates to methods of enhancing normal melanocortin-4 receptor (MC4R) activity, and to enhancing activity of an MC4R having a mutation which affects protein folding and/or processing of the MC4R. The invention provides a method of treating an individual having a condition in which increased activity of an MC4R at the cell surface would be beneficial, for example in obesity, by administering an effective amount of a pharmacological chaperone for the MC4R. The invention provides...

VACCINES COMPRISING HEAT-SENSITIVE TRANSGENES

University of Victoria, UVIC INDUSTRY PARTNERSHIPS

The present disclosure provides temperature sensitive essential nucleic acid molecules from a psychrophilic bacterium, proteins encoded by the nucleic acid molecules, as well as recombinant cells into which have been introduced such nucleic acid molecules. The disclosed recombinant cells containing one or more essential nucleic acid molecules from a psychrophilic bacterium are thereby made temperature sensitive and can be administered to a mammal to induce an immune response in the mammal.

TDP-43-BINDING POLYPEPTIDES USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

Laval University

Provided herein are antigen-binding constructs such as antibodies that bind to the RRM-1 domain of TDP-43. The antigen-binding constructs are capable of blocking the interaction of TDP-43 with NF-.kappa.B in cells. Also provided herein are method of using the antigen-binding constructs in the treatment of diseases associated with TPD-43 proteinopathy, such as amyotrophic lateral sclerosis (ALS), frontotemperal lobar degeneration (FTLD), Lewy body disease and motor neuron disease.

Proaerolysin containing protease activation sequences and methods of use for treatment of prostate cancer

Johns Hopkins University, University of Victoria, UVIC INDUSTRY PARTNERSHIPS

Disclosed herein are modified proaerolysin (PA) peptide. In some examples, the proteins include a prostate-specific protease cleavage site and can further include a prostate-tissue-specific binding domain which functionally replaces the native PA binding domain. In other examples, The proteins include a furin cleavage site and a prostate tissue-specific binding domain which functionally replaces the native PA binding domain. Methods of using such peptides to treat prostate cancer are also disclosed.

Improved amino lipids and methods for the delivery of nucleic acids

Arbutus Biopharma, LAHERTY, CAROL, D, Tekmira Pharmaceuticals, University of British Columbia

The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipid having the structure below and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses....

RHODOCOCCUS AETHERIVORANS BCP1 AS CELL FACTORY FOR THE PRODUCTION OF INTRACELLULAR TELLURIUM AND/OR SELENIUM NANOSTRUCTERS (NANOPARTICLES OR NANORODS) UNDER AEROBIC CONDITIONS

ALMA MATER STUDIORUM - UNIVERSITY OF BOLOGNA, University of Calgary

The present disclosure relates generally to the production of tellurium and selenium nanostructures in bacteria. The nanostructures are unique in size, shape, length and stability.

Anti-angiogene compositions and methods of use

ANGIOGENESIS TECHNOLOGIES, ANGIOTECH PHARMACEUTICALS, University of British Columbia

The present invention provides compositions an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-invasive Factor, Retinoic acids and derivatives therof, and taxol. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.

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