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Select: All | None

Select: All | None

Featured Opportunity

Novel Selective Cyp26 Antagonists for Dermatological Diseases

Queen's University

Cyp26 inhibitor compounds treat diseases such as psoriasis, while avoiding retinoid related side effects
Featured Opportunity

A Novel Class of Antibiotics

McMaster University

Three novel, cyclic, streptogramin-like antibiotics in which the ester bond has been replaced with a highly stable amide bond. This results in enhanced stability against the Vgb inactivating enzymes while maintaining antibiotic activity. Antibiotics function via a novel mod
Featured Opportunity

PAD Inhibitors for Treatment of Multiple Sclerosis

University Health Network

Small molecule inhibitors of protein arginine deiminases (PAD) for treatment of multiple sclerosis and other neurodegenerative disorders Multiple sclerosis is a neurodegenerative condition that results in cognitive and physical disability and shortened life expectancy that affects more than 2.5 million people globally. MS is the most common demyelinating neurodegenerative disease. Current therapies for MS do not delay the progression of, or support the reversal of the disease. The majority...
Featured Opportunity

FAE1 an Early Seed-Specific Promoter

University of British Columbia

This FAE I promoter technology provides seed-specific expression in plants, offering a competitive alternative to the widely used napin and phaseolin promoters. FAE1 promoter constructs can be used in transgenic plants to promote expression of heterologous, agronomically-valuable sequences in developing seeds. Offers a competitive alternative to the widely used napin and phaseolin promoters. Can affect seed lipid metabolism, seed development, and protein or carbohydrate composition and...
Featured Opportunity

FAE1 an Early Seed-Specific Promoter

University of British Columbia

This FAE I promoter technology provides seed-specific expression in plants, offering a competitive alternative to the widely used napin and phaseolin promoters. FAE1 promoter constructs can be used in transgenic plants to promote expression of heterologous, agronomically-valuable sequences in developing seeds. Offers a competitive alternative to the widely used napin and phaseolin promoters. Can affect seed lipid metabolism, seed development, and protein or carbohydrate composition and...
Featured Opportunity

Method of lethally sensitizing human and animal cells

Laval University

DescriptionCellular DNA damage response and/or DNA repair pathways are targets of choice to enhance the potency of DNA damage agents such as ionizing radiation. Poly(ADP-ribosyl)ation is one of the first cellular response to DNA damage. Polymers of ADP-ribose (PAR) are synthesized by poly(ADP-ribose) polymerases in the presence of DNA damage. PAR are covalently attached to a multitude of nuclear proteins, including some DNA repair enzymes, causing the protein to momentarily loss their...
Featured Opportunity

Novel Nucleoside-based Antiprotozoan Drugs: New Anti-Malarial, Tech ID # 044.21

University of Calgary

Infectious diseases caused by parasites are a serious global health problem with significant rates of morbidity and mortality. Due to the emergence of treatment-resistant strains of many pathogens, there is a clear need for novel approaches to infectious diseases.
Featured Opportunity

Small molecule inhibitors of PNKP, a DNA repair enzyme, for cancer therapy

University of Alberta

first in class targeted cancer therapy focused on synthetic lethality
Featured Opportunity

IMMUNOMODULATORY DAIRY PEPTIDES AND THEREOF

Laval University

DescriptionBovine milk proteins are well-known to contain numerous bioactive peptides, which are encrypted within their primary sequence. However, only a limited number of peptides modulating the immune system have been identified. The proposed method is simple and allows the preparation of whey proteins enzymatic hydrolysates containing a number of immunomodulatory peptides. These peptides stimulate both the secretion of Th1- or Th2-cytokines inducing pro- or anti-inflammatory effect. The...
Featured Opportunity

Quantification of Cellulase Activity

University of British Columbia

Advantages This technology enables the detection and quantification of active cellulases in a complex biomass mixture over time.  Specific to: endo-b-glucanases: EG1 and EG2 cellobiohydrolases: CBH1 and CBH2 The amount of active cellulases can be easily determined using a combination of3 labelling agents and 3 blocking agents specific to EG1 EG2 as well as CBH1 and CBH2. Technology Details The enzymatic conversion of biopolymers to biofuels is a sophisticated way to make...

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