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Select: All | None

Select: All | None

METHODS AND COMPOSITIONS OF ANTI-CRISPR PROTEINS FOR USE IN PLANTS

DUPONT NUTRITION BIOSCIENCES APS, Laval University

Methods and compositions are provided for the use of anti-CRISPR (ACR) proteins in plants, including modulation of Cas endonuclease activity, improvement of frequency of homologous recombination, control of Cas endonuclease activity during various cell cycles, spatial and/or temporal regulation of Cas endonuclease activity in plants, usage in gene activation or repression, as well as reduction of off-target polynucleotide cleavage.

MARKERS ASSOCIATED WITH ENDOMETRIAL DISEASE

Sinai Health System, University Health Network, York University

Methods for detecting endometrial diseases or an endometrium phase in a subject are described comprising measuring endometrial markers or polynucleotides encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for endometrial diseases, and kits for carrying out the methods of the invention. The invention also contemplates therapeutic applications for endometrial diseases employing endometrial markers, polynucleotides encoding the...

MICRORNA BIOMARKERS FOR PROSTATE CANCER

CHARITE UNIVERSITY HOSPITAL, St. Michael's Hospital, University Health Network

The invention relates in general to novel biomarkers for detection of prostate cancer, and more particularly to the analysis of microRNA (miRNA) gene products and microRNA signatures in low and high risk prostate cancers.

SCREENING METHOD FOR SELECTED AMINO LIPID-CONTAINING COMPOSITIONS

Alnylam Pharmaceuticals

The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-Dilinoley 1-4- dimethylaminomethyl-[l,3]-dioxolane by screening for an effect of the agent on the liver of a model subject.

PROGNOSTIC AND PREDICTIVE GENE SIGNATURE FOR NON-SMALL CELL LUNG CANCER AND ADJUVANT CHEMOTHERAPY

University Health Network

The application provides methods of prognosing and classifying lung cancer patients into poor survival groups or good survival groups and for determining the benefit of adjuvant chemotherapy by way of a multigene signature. The application also includes kits and computer products for use in the methods of the application.

Cancer antigen MAGE-A9 and uses thereof

Laval University

The present invention relates to the detection of MAGE-A9 in a biological sample and to the diagnosis, prevention and treatment of MAGE-A9-associated aberrant cell growth, through the targeting of the MAGE-A9 polypeptide and/or polynucleotide. Diagnosis is accomplished by examining or monitoring cells for perturbations in MAGE-A9 expression. Prevention and treatment are accomplished by administering to a subject MAGE-A9 as a protein or a fragment thereof or under form of a DNA expression...

SERUM BIOMARKERS FOR CHAGAS DISEASE

CIPHERGEN BIOSYSTEMS, McGill University

The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying Chagas disease status in a patien t. In particular, the biomarkers of this invention are useful to classify a subject sample as infected with Chagas disease or non-infected. The biomarke rs can be detected by SELDI mass spectrometry.

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