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Kin-8 mouse adrenal tumor cells

University of Toronto

DescriptionKin8 cells harbor a dominant inhibitory point mutation in the type 1 regulatory subunit of protein kinase A that renders the enzyme resistant to activation of cAMP and its analogs. The cell line is useful for evaluating the regulatory roles of cAMP and protein kinase A. Properties of this mutant have been reviewed in: Rainey, WE, Saner, K, Schimmer, BP: Adrenocortical cell lines. Mol Cell Endocrinol 228: 23-28 (2004). Potential ApplicationsStudies of the role of protein kinase A...

METHODS, COMPOSITIONS AND KITS FOR THE EVALUATION AND PRESERVATION OF SPERM

L'ALLIANCE BOVITEQ, Laval University

The invention concerns methods and kits for evaluating the semen quality. The invention also concerns compounds and compositions for preserving a sperm sample, especially during cryopreservation. The invention is based on a correlation between sperm phosphodiesterase (PDE) activity and sperm fertility and on the use of selective phosphodiesterase inhibitors, more particularly PDE10 inhibitors.

METHODS FOR GENERATING HEPATOCYTES AND CHOLANGIOCYTES FROM PLURIPOTENT STEM CELLS

Hospital for Sick Children, University Health Network

Methods for producing hepatocyte and/or cholangiocyte lineage cells from pluripotent stem cells, the method comprising (a) specifying the extended nodal agonist treated induced endodermal cell population to obtain a cell population comprising hepatocyte and/or cholangiocyte progenitors by contacting the extended nodal agonist treated induced endodermal cell population with specification media comprising a FGF agonist and a BMP4 agonist and/or active conjugates and/or fragments thereof; (b)...

METHODS OF PRODUCING VENOUS ANGIOBLASTS AND SINUSOIDAL ENDOTHELIAL CELL-LIKE CELLS AND COMPOSITIONS THEREOF

University Health Network

Disclosed herein are methods of producing a population of venous angioblast cells from stem cells using a venous angioblast inducing media and optionally isolating a CD34+ population from the cell population comprising the venous angioblast cells, for example using a CD34 affinity reagent, CD31 affinity reagent and/or CD144 affinity reagent, optionally with or without a CD73 affinity reagent as well as methods of further differentiating the venous angioblasts in vitro to produce SEC-LCs...

TRANSGENIC CELLS FOR IDENTIFYING GPCR SIGNALING COMPOUND MODULATING GPCR SIGNALING PATHWAY AND SCREENING METHOD THEREOF

Laval University

The present invention provides a transgenic cell co-expressing at least one ionic channel and at least one G-protein coupled receptor (GPCR), wherein at least one GPCR signaling pathways is modulated by a GPCR signaling compounds. The present invetion also provides a screening method for identifying said GPCR signaling compound. Also disclosed is that voltage gated sodium channels (NaV) interact in neurons in vivo with both dopamine (DA) receptors and serotonin (5-HT) G protein coupled...

INHIBITING CYCLIN D POLYPEPTIDES

Mayo Foundation, University Health Network

Published without an

PEPTIDES AND METHODS FOR PREVENTING ISCHEMIC TISSUE INJURY

University Health Network

Provided are GLP-1 C-terminal peptides and methods of use for the treatment or prevention of ischemic tissue injury. The peptides correspond to GLP-l(28-36). FIAWLVKGR and GLP-l(28-37) FIAWLVKGRG and are useful in the treatment or prevention of ischemic tissue injury, including ischemic heart disease or stroke

THERAPEUTICS FOR THE INDUCTION OF ENDOGENOUS STEROIDOGENESIS AND METHODS ASSOCIATED WITH THEIR IDENTIFICATION

McGill University

The present disclosure provides agents capable of promoting endogenous steroid production (such as endogenous testosterone production) without altering the endogenous luteinizing hormone. The present disclosure also provides associated therapeutic methods as well as screening assays for identifying further therapeutic agents for the prevention, treatment and/or alleviations of symptoms associated with hypogonadism.

COMPOUNDS HAVING PEPTIDES CONJUGATED TO BONE TARGETING MOIETIES AND METHODS OF MAKING AND USING THEREOF

University of Alberta

Described herein are compositions having a peptide sequence that includes at least one bone targeting moiety, wherein the bone targeting moiety is bonded to the peptide sequence by a linker, wherein the peptide sequence is calcitonin, and wherein the composition is neutral or a pharmaceutically acceptable salt or ester thereof. In one aspect, calcitonin inhibits or slows osteoclast mediated resorptive bone loss. The compounds described herein can be used in a number of therapeutic...

A METHOD OF TREATING OBESITY

McMaster University

A method of treating obesity and obesity-related disorders in a mammal is provided. The method comprises the step of administering to the mammal a compound that inhibits the synthesis or activity of peripheral serotonin, including a Tph1 inhibitor or a serotonin receptor inhibitor.

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