Voula Kanelis

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Recent Research Projects

Studies of the effects of phosphorylation and protein interactions on ATP-binding casette transporter activity

2015/16-2019/20 • $150,000 • PI
The protein Ycf1p is a member of a large superfamily of membrane proteins found in all organisms. By utilizing the energy of ATP, known as the energy currency of the cell, these proteins actively transport solutes into and out of the cell, regulate the function of other proteins, or open pores...

Studies of the molecular mechanisms by which mutations in the SUR2A NBDs cause cardiovascular diseases

2012/13-2017/18 • $300,000 • PI
Potassium ion channels in cells are essential for healthy hearts. These channels are formed from two different types of proteins. One protein, called Kir6.2, forms the channel pore while the other protein, known as SUR2A, regulates opening and closing of the pore. Proper control of the channel...

Studies of the molecular mechanisms by which mutations in the SUR2A NBDs cause cardiovascular diseases

2010/11-2015/16 • $502,336 • PI
Potassium ion channels in cells are essential for healthy function of the heart. These channels are formed from two different types of proteins. One protein, called Kir6.2, forms the channel pore while the other protein, known as SUR2A, regulates opening and closing of the pore. Proper control...

Investigations into the molecular basis of regulation of ATP-sensitive K+ chaannels by SUR proteins, members of ABC transporters

2010/11-2014/15 • $145,000 • PI
The sulphonyl urea (SUR) protein family is a member of a large superfamily of membrane proteins found in all organisms. By utilizing the energy of ATP, known as the energy currency of the cell, these proteins bind compounds at the membrane and/or actively transport solutes into and out of the...

Effects of phosphorylation on the structure and interactions of the sulfonylurea receptor's nucleotide binding domains

2012/13-2014/15 • $105,000 • Scholarship/Fellowship,Other
Healthy hearts require specific levels of potassium to function properly. The amount of potassium that enters heart cells is controlled by a protein, SUR2A. Problems with this protein are responsible for a number of cardiovascular disorders, such as heart attacks and cardiac disease. We will use...

Examining Biomolecular Interactions using Microscale Thermophoresis

2013/14 • $150,000 • PI,CO
As part of a team of 10 structural biologists at the University of Toronto (spanning several departments and faculties), we use biophysical tools such as Atomic Force Microscopy, NMR spectroscopy, X- ray crystallography and electron cryomicroscopy to analyze the biomolecular interactions between...

Patents