Christophe Grova

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Recent Research Projects

Electrical and metabolic manifestations of human focal epilepsy

2015/16-2019/20 • $1,957,140 • PI,Other
Overarching direction. Many patients with focal epilepsy are refractory to medical treatment. Surgical treatment is then the only option. Defining the region to resect is complex and far from fool proof. Some patients cannot be operated because the focus is not found; in operated patients, the...

The importance of connector hubs in focal epilepsy: a multimodal investigation

2018/19-2019/20 • $445,230 • PI,CO
Epilepsy is a neurological disorder that affects 1% of Canadians. The main treatment is longterm drug therapy, to which more than 30% of patients are refractory. Fortunately, surgery may be considered in cases of drug resistant epilepsy in which we can define a focal area of the brain...

Pathophysiology of Narcolepsy and Idiopathic Hypersomnia: a Multimodal Neuroimaging Study

2018/19-2019/20 • $296,820 • PI,CO
Narcolepsy is a disorder characterized by excessive sleepiness: patients fall asleep during the day without being able to resist the urge to sleep. Narcolepsy is often accompanied by sudden episodes of muscle weakness triggered by emotions and termed cataplexy. Research in the past decade...

Multimodal integration of functional neuroimaging data

2018/19-2019/20 • $66,000 • PI
Based on different physical and physiological principles, several non-invasive neuroimaging techniques are now available to study the brain in function. However, the ideal technique that would explore brain neuronal activity at a millimeter scale and at a millisecond scale does not exist....

Multimodal identification of the neurovascular coupling within the epileptogenic network

2014/15-2017/18 • $486,582 • PI,CO
Epilepsy is a neurological disorder that affects 1% of Canadians. The main treatment is long-term drug therapy, to which more than 30% of patients are refractory. Fortunately, surgery may be considered in cases of drug resistant epilepsy in which we can define a focal area of the brain...

Multimodal integration of functional neuroimaging data

2013/14-2017/18 • $175,000 • PI
More and more non-invasive neuroimaging techniques are now available to study normal brain functions but also brain disorders. However, it does not exist any ideal exploration technique able to measure precisely "when" (at a ms scale) and "where" (at a mm scale) an activity occurred in the...

Multimodal integration of functional neuroimaging data

2013/14-2015/16 • $120,000 • PI
No summary

How focal is focal epilepsy?

2010/11-2011/12 • $222,930 • PI,CO
In the investigation of patients with focal epilepsy, the main goal has been the localization of the brain region responsible for the seizures, the so-called epileptic focus. This is mainly driven by the search for a potential target for surgical treatment, aiming to render the patient...

Patents