Daniel Goldowitz

Contact via University of British Columbia

Key Research Areas
Associated Researchers
Associated Organizations

Recent Research Projects

CHILD-BRIGHT: Child Health Initiatives Limiting Disability- Brain Research Improving Growth and Health Trajectories

2015/16-2020/21 • $12,760,751 • PI,Other
The CHILD-BRIGHT network will achieve brighter futures for children with brain-based developmental disabilities (BDD) and their families by creating novel interventions to optimize development, promote healthy outcomes, and deliver responsive and supportive services across the life-course. Our...

Prenatal Programming of Children's Mental Health: Epigenetic Mechanisms and Resilience Promotion

2016/17-2020/21 • $1,531,290 • PI,CO,Other
Risk factors for disease can develop in utero, and children's mental health in early life plays an important role in later disease development. This research will 1) test whether multiple sources of stress during pregnancy predict biological marks in the offspring and whether those marks predict...

Canada Research Chair in Developmental Neurogenetics

2014/15-2020/21 • $1,300,000 • PI
Dr Daniel Goldowitz's research in neurodevelopment spans bench-to-bedside. His bench research focuses on the molecules engaged in development of the human brain, particularly the cerebellum, a region involved in important functions in motor control, social behaviour, and learning. Dr Goldowitz...

Cognitive Behaviour Therapy for Mental Health Problems in Children with Neurodevelopmental Disorders: A Transdiagnostic Approach

2016/17-2020/21 • $786,756 • PI,CO
Mental health problems are a serious set of issues for youth with neurodevelopmental disorders, a term that refers to children diagnosed with autism spectrum disorder, fetal alcohol spectrum disorder, cerebral palsy, learning disabilities or attention deficit hyperactivity disorder (ADHD). These...

Innovative National Strategies for Patient-Oriented Research Education / Stratégies Nationales Innovantes pour l'Éducation en Recherche axée sur le Patient (INSPIRE)

2020/21 • $41,667 • PI,CO,Other
INSPIRE aims to support meaningful and sustainable capacity development in the broader Canadian patient-oriented research (POR) community by enabling and supporting the capacity development and career paths of stakeholders and community members in an innovative, systematic and personalized...

NeuroDevNet

2014/15-2019/20 • $8,183,000 • PI
No summary

The THRIVE collaborative: an initiative to improve our understanding of the factors that determine resiliency and risk using a DOHaD framework

2019/20 • $19,875 • PI,CO
THRIVE: Tracking Human Resiliency In Varying Environments is a novel research approach that attempts to identify factors that provide children resilience against adversities. Currently, our understanding of the role that early life exposures have on poor health outcomes remains severely limited...

Innovative National Strategies for Patient-Oriented Research Education / Stratégies Nationales Innovantes pour l'Éducation en Recherche axée sur le Patient (INSPIRE)

2019/20 • $7,419 • PI,CO,Other
INSPIRE aims to support meaningful and sustainable capacity development in the broader Canadian patient-oriented research (POR) community by enabling and supporting the capacity development and career paths of stakeholders and community members in an innovative, systematic and personalized...

Kids Brian Health Network (NeuroDevNet)

2016/17-2018/19 • $5,553,000 • PI
No summary

Identification of Transcription Factor Networks in Mammalian Brain Development

2017/18 • $28,000 • PI
The mammalian brain is a highly complex biological system and understanding how the brain develops is a daunting task. Determining the underlying molecular processes that are involved in brain development can be a strong first step toward this goal. One region of the brain, the cerebellum, which...

Identification of Transcription Factor Networks in Mammalian Brain Development

2012/13-2016/17 • $140,000 • PI
The mammalian brain is a highly complex biological system and understanding how the brain develops is a daunting task. Determining the underlying molecular processes that are involved in the brain development can be a strong first step toward this goal. One region of the brain, the cerebellum,...

NeuroDevNet / NeuroDevNet

2014/15-2015/16 • $3,287,000 • PI
No summary

Measuring the impact of the induction of a massive systemic inflammatory response on a developing mouse brain having undergone a prior perinatal insult with or without underlying immunodeficiency.

2013/14-2015/16 • $105,000 • Scholarship/Fellowship,Other
The extreme preterm infants, born at 28 weeks old or less, have been a new population reality for about three decades. As a medical community we strive to increase their survival rate, but what do we do for their quality of life? These children are here, they have survived and now they are a...

Prenatal Programming of Children's Mental Health: Epigenetic Mechanisms and Resilience Promotion

2015/16 • $10,000 • PI,CO
Risk factors for disease can develop in utero, and children's mental health in early life plays an important role in later disease development. This research will 1) test whether multiple sources of stress during pregnancy predict biological marks in the offspring and whether those marks predict...

The Neurodevelopment Network

2010/11-2014/15 • $12,322,635 • PI
No summary

Canada Research Chair in Developmental Neurogenetics

2010/11-2014/15 • $900,000 • PI
Developmental disorders of the brain, which have a large toll on the individual, family and society, can have a clear genetic basis (e.g., some forms of mental retardation) or a more complex cause arising from gene-environment interactions (e.g., autism and attention deficit disorder). As Tier 1...

Cellular targets of kainate-induced neuron death in the hippocampus

2010/11-2014/15 • $572,137 • PI
Proper brain function relies on the communication between cells (neurons) in the brain and this largely depends on excitatory and inhibitory actions between neurons. The disruption of this balance can result in epilepsy and seizures and the death of neurons that are over-stimulated. In the...

Improving Lives of Children and Youth with Neurodevelopmental Disabilities

2014/15 • $50,000 • PI,Other
Neurodisabilities such as Down Syndrome and epilepsy profoundly affect the lives of as many as one in six Canadian children and their families. In addition to their main diagnosis, many children with a neurodisability also have other chronic conditions such as attention deficit hyperactivity...

NeuroDevNet / NeuroDevNet

2010/11-2013/14 • $1,935,500 • PI
No summary

Age Related Effects of Nicotine on the Transcriptome, Epigenome, and Behaviour

2010/11-2013/14 • $130,778 • Scholarship/Fellowship,Other
Cigarette smoking is an addiction that is the most preventable cause of premature death in the world. Approximately 90% of adult smokers initiate tobacco use before age 18, and this early behaviour could be critical to addiction. There is evidence that early exposure to nicotine, the addictive...

Novel DNA-Integration Tools for Stem Cell and Gene Therapy Research

2010/11-2011/12 • $156,877 • PI,CO
Embryonic Stem Cell Research has greatly enhanced our understanding of biological development; combined with gene cloning advances multiple techniques have been generated allowing us to study the function of certain genes in development, disease states and the applications of gene therapy. The...

Mouse epigenomics: A toolkit for translational research

2011/12 • $100,000 • PI,CO
The current revolution in understanding the role that genes play in health and disease is being played out in the environment, that is: how the environment and events we experience can powerfully modulate our gene function and impact our response to life's challenges. To best understand the...

Patents