Recent Research Projects

Cocooning Therapeutic Cells

2015/16-2017/18 • $261,805 • PI,Other
Medical therapies using undifferentiated cells (stem and progenitor) are emerging and are defining a new era in regenerative medicine. Our proposed research study targets the development of a cell encapsulation process for delivery to patients suffering from severe life-threatening disorders....

Microfluidic and Nanofluidic Biotechnologies for Applications in the Health Sciences

2014/15-2017/18 • $88,000 • PI
The nature of disease, from its biological origins to its identification and management in patients, is inherently complex. Advances in the development of novel biophysical analytical capabilities provide researchers access to new insight into the biological origins of disease, while empowering...

Cocooning Therapeutic Cells

2015/16-2016/17 • $261,803 • PI,CO
Medical therapies using undifferentiated cells (stem and progenitor) are emerging and are defining a new era in regenerativemedicine. Our proposed research study targets the development of a cell encapsulation process for delivery to patientssuffering from severe life-threatening disorders....

Identify and quantitate biomarkers using nanopores fabricated by controlled breakdown

2016/17 • $242,940 • PI,CO
As nanometer-scale holes embedded in thin insulating membranes, nanopores provide a confined space withinwhich single molecules can be captured and electrically interrogated with high throughput. However commercialization of nanopore-based technologies for health science applications, including...

Microfluidic mechanical stimulation bioreactor

2016/17 • $12,500 • PI
Mechanical forces cause tissues and cells in the body to stretch as part of their normal function. In fact, some degree of mechanical stretch is required to maintain healthy tissues, while overstretching can cause damage or lead to disease. The effects of stretch on tissue and cell function,...

Development of a low cost solid-state nanopore fabrication method

2013/14-2015/16 • $200,499 • PI,CO
Nanopores are nanometer-scale holes embedded in thin insulating membranes. They provide a confined space within which single molecules can be captured and electrically interrogated at high throughput. Following 15 years of active research, nanopore-based sensors have emerged as the leading...

Microfluidic mechanical stimulation bioreactor

2015/16 • $25,000 • PI
Mechanical forces cause tissues and cells in the body to stretch as part of their normal function. In fact, some degree of mechanical stretch is required to maintain healthy tissues, while overstretching can cause damage or lead to disease. The effects of stretch on tissue and cell function,...

Manufacturing encapsulated therapeutic cells and enhancing purity using a microfluidic device

2014/15 • $25,000 • PI
The use of stem or progenitor cells in regenerative medicine applications holds the potential to revolutionizethe treatment of various diseases by restoring normal function to diseased or damages organs. NorthernTherapeutics Inc. (NTHx) is dedicated to the development of novel cell-based...

Biophysical sensing at the micro- and nano-scale

2010/11-2013/14 • $119,000 • PI
There is an ever-growing need for novel and more powerful quantitative analytical techniques used to explore the complex world of biological systems. In the last decade or so, new microfabrication technologies have begun to bridge the gap between silicon processing and biology, enabling the...

Patents

METHOD FOR CONTROLLING THE SIZE OF SOLID-STATE NANOPORES

A method is provided for precisely enlarging a nanopore formed in a membrane. The method includes: applying an electric potential across the nanopore, where the electric potential has a pulsed waveform oscillating between a high value and a low value; measuring current flowing though the nanopore while the electric potential is being applied to the nanopore at a low value; determining size of the nanopore based in part on the measured current; and removing the electric potential applied to...
Related applications: CA20132872600, EP20130787360, EP20130787360, ES20130787360T

INTEGRATING NANOPORE SENSORS WITHIN MICROFLUIDIC CHANNEL ARRAYS USING CONTROLLED BREAKDOWN

Nanopore arrays are fabricated by controlled breakdown in solid-state membranes integrated within polydimethylsiloxane (PDMS) microfluidic devices. This technique enables the scalable production of independently addressable nanopores. By confining the electric field within the microfluidic architecture, nanopore fabrication is precisely localized and electrical noise is significantly reduced during sensing.
Related applications: EP20150869455, CA20152970627, WO2015IB59799