Karim Fouad

Contact via University of Alberta

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Recent Research Projects

Spinal Cord Injury

2016/17-2020/21 • $1,000,000 • PI
A spinal cord injury is a devastating event with life-long consequences as our nervous system is unable to repair itself. This program addresses the urgent need for treatments by following two research streams in animal models of spinal cord injury. One stream is focused on promoting...

Treating spinal cord injury by augmenting activity dependent cellular pathways driving neuronal plasticity

2017/18-2020/21 • $599,760 • PI
Spinal cord injuries damage nerve fibers that connect our brain to the rest of the body. Because these fibers cannot regrow effectively the result is dramatic and permanent. However there are mechanisms that allow a moderate recovery, especially when a portion of the nerve fibers have been...

Role of extrasynaptic GABA in the recovery of motor function after spinal cord injury.

2019/20-2020/21 • $463,958 • PI
This proposal explores a fundamentally new mechanism for regulating nerve conduction in the spinal cord, with far reaching implications to understanding normal sensorimotor control and opening new therapeutic opportunities for restoring locomotion after spinal cord injury (SCI). While the...

Modulation of spontaneous and rehabilitation-induced recovery after stroke by pleiotrophin

2019/20-2020/21 • $326,103 • PI,CO
Stroke refers to brain damage due to blocked blood flow in the brain. The spinal cord can "rewire" itself to help stroke survivors recover movement. Sadly, recovery is not complete. Incomplete recovery may be because the spinal cord rewires only for a short period of time after stroke. A protein...

Targeting pericytes to restore sensorimotor function after spinal cord injury

2020/21 • $244,144 • PI
Spinal cord injury disconnects the brain from parts of the body below the injury, resulting in paralysis, abnormal pain and bladder dysfunction. Unfortunately, treatments to repair the injured spinal cord are still lacking. However, we recently made the unexpected discovery that blood flow is...

Patterned electrical stimulation of the arms and legs to improve walking after spinal cord injury

2014/15-2018/19 • $994,127 • PI,CO
When we walk, we swing our arms in rhythm with our legs. This relationship between the arms and legs is needed to improve our balance and our ability to walk efficiently. We want to find out if people with spinal cord injury or stroke trained using electrical stimulation and exercise machines...

Roles of cAMP and training in the recovery of reaching after spinal cord injury

2012/13-2016/17 • $858,715 • PI
There are currently no treatments that promote substantial functional recovery following a persons spinal cord injury (SCI). However, findings of adaptive changes, in other words, plasticity, in the adult nervous system are beginning to offer new avenues of potential treatment. In an animal...

Recovery of locomotion mediated by interneuron regeneration following complete spinal cord injury

2012/13-2016/17 • $815,235 • PI
In contrast to the peripheral nervous system, nerve cells in the central nervous system (CNS: i.e. brain or spinal cord) cannot spontaneously regenerate their connections. Consequently, after a spinal cord injury (SCI) individuals permanently suffer from the loss of sensory, motor, and autonomic...

The effects of high-frequency rehab training on muscle physiology following spinal cord injury

2015/16 • $5,000 • Scholarship/Fellowship,Other
ICS Studentship

Commissural interneurons in locomotion and spasticity after spinal cord injury

2013/14-2014/15 • $71,251 • Scholarship/Fellowship,Other
The spinal cord is the primary neurological link between the brain and the rest of the body. Damage to the spinal cord can cause paralysis to regions below the injury site, followed by secondary symptoms, such as muscle spasticity. Normally, there is limited recovery of motor and sensory...

Combining axonal growth promoting treatments with rehabilitative training

2010/11 • $48,139 • PI
Injury to the spinal cord causes disruption of descending and ascending axons. This results in deficits in sensory perception as well as motor control. While axonal regeneration in the central nervous system does not naturally occur, some forms of repair after injury and gradual attenuation of...



Systems and techniques for task training laboratory animals are described. The systems and techniques may be particularly useful for training laboratory rodents to perform a single pellet grasping (SPG) task. A system for training animals may include a task enclosure having a slit at one end. A system may include an automated pellet retrieval system. A system may include a sensor system. A system may include a computing device configured to receive data from a sensor system and cause pellet...
Related applications: WO2015IB58533