Sarah Kimmins

Key Research Areas
Associated Researchers
Associated Organizations

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Recent Research Projects

TRajectories Of healthy life using Public Health and primary care Interventions in Canada: The TROPHIC Trial

2017/18-2019/20 • $4,800,000 • PI,CO,Other
The "Developmental Origins of Health and Disease (DOHaD)" hypothesis suggests that a healthy growth and development in pregnancy and early childhood is critical for optimal health and lifetime wellbeing. Yet, Canada's children are falling behind. Nearly 1 in 3 Canadian children are overweight or...

Father's lasting influence: Molecular foundations of intergenerational transmission of the paternal environment.

2014/15-2019/20 • $1,494,000 • PI,CO,Other
We know that maternal exposures can affect child health, but recent disturbing findings suggest that the effects of environmental exposures can be transmitted by fathers, causing adverse birth outcomes and disease in their children, grandchildren and great-grandchildren. A possible mechanism for...

Generational and sex-specific effects of paternal environmental exposures on offspring development health

2016/17-2019/20 • $1,244,200 • PI,CO,Other
How memory of environmental exposures is transmitted from parents to children and even to great grandchildren to alter disease susceptibility is largely unknown. This pheneomena, known as epigenetic inheritance has been associated to biochemical modifications to the heritable information coded...

Obesity and nutritional programming of the paternal sperm epigenome: effects on offspring development and health

2015/16-2019/20 • $1,023,246 • PI,CO
The impact of diet and body condition on the father's reproductive health and that of his offspring has been relatively under-explored and under-emphasized. Over the past two decades male fertility is declining as measured by lowered sperm counts, increased DNA damage in sperm and rising rates...

Novel functional outcomes of vitamin D in infancy; can correction of low vitamin D status program for a leaner body composition phenotype?

2015/16-2019/20 • $837,819 • PI,CO
One in four infants are born with low amounts of vitamin D stored in their body. This study is designed to test whether improving vitamin D status quickly after birth helps infants to build muscle and to normalize growth. This is important since the investigators have noticed in previous work...

Epigenetics, Reproduction and Development

2016/17-2019/20 • $400,000 • PI
New research suggests that heritable disease may begin by environmental exposures of the father. While the importance of preconception health of the mother has long been known, the important role of the father is only now being recognized and paternal preconception guidelines need to be...

Canadian Epigenetics, Environment and Health Research Consortium Network Phase II

2019/20 • $267,500 • PI,CO
The DNA that makes up the genome (the collection of all the DNA in your cell) is tagged with various chemical marks that are attached either directly to the DNA or to its packaging proteins. These marks, collectively called the epigenome, act as a kind of molecular mark-up language that tells...

The ACORN Study: A life course approach to aging and the causal role of the microbiome

2018/19 • $25,000 • PI,CO,Other
It has long been thought that our health, disease risk and even the way in which we age are determined largely by our genetics and lifestyle. We now know that although genetics contributes to health and aging, it plays a relatively minor role and the environment is a major factor. But, despite...

CIHR Training Program in Integrative Approaches to Human Health

2010/11-2015/16 • $1,607,145 • PI,CO
High-throughput (eg microarrays, sequencing) and high-content (eg single cell imaging, chemical screening) assays are now an integral part of biomedicine, and have produced successes that are now finding clinical utility. This is true for a range of human diseases including cancer, diabetes,...

Canada Research Chair in Epigenetics, Reproduction and Development

2011/12-2015/16 • $500,000 • PI
The use of assisted reproductive techniques for infertile couples is increasing. Will the use of sperm and oocytes (gametes) from infertile parents increase birth defects and alter offspring health? Infertility has been associated to changes in the epigenetic program of sperm. Epigenetics is...

Generational and sex-specific effects of paternal environmental exposures on offspring development health

2015/16 • $10,000 • PI,CO
It is well known that a mother's health is essential to that of her children but a father's role in his offspring's health has been comparatively ignored. We are working with an international team of world leading experts to develop pre-conception health guidelines for men to improve the health...

The role of the epigenome in spermatogenesis, sperm function and embryo health

2010/11-2014/15 • $607,277 • PI
Globally there have been reported increases in male infertility and reproductive disorders such as testis cancer. Both these conditions are associated with changes to what is known as the epigenetic program. Epigenetics is used to describe heritable biochemical information that sits on the DNA...

Obesity and nutritional programming of the paternal sperm epigenome: effects on offspring development and health

2014/15 • $100,000 • PI,CO
The greatest cause of neonatal death is birth defects, which occur at a rate of 1/33 births. In 50% of cases the cause is unknown. Prevention of birth defects is directed at the mother, yet the father contributes 50% of the heritable information. This mode of thinking that it is all up to the...

NSERC EmbryoGENE Strategic Network

2010/11-2013/14 • $3,452,850 • PI,CO
No summary

Molecular underpinnings of how paternal prenatal exposure to environmentally-relevant organochlorines compromises health of future generations: A possible mechanism for health discrepancies between Northern Aboriginal and non-Aboriginal Canadians

2013/14 • $100,000 • PI,CO
Society is concerned about the impact of environmental contaminants on human health. Numerous highly publicized reports of deformities, disease and infertility have been attributed, at least in part, to environmental contaminants. Many contaminants work their way up the food chain, as is the...

Father's lasting influence: Molecular foundations of transgenerational transmission of the paternal environment

2013/14 • $10,000 • PI,Other
We know that maternal exposures can affect child health, but recent disturbing findings suggest that the effects of environmental exposures can be transmitted by fathers, causing adverse birth outcomes and chronic disease in their children, grandchildren and great-grandchildren. A possible...

Nutrient-epigenetic interactions in the germline

2010/11 • $39,556 • PI
No summary

Is histone H3K4 methylation a key epigenetic signature in stem cell fate and germ cell differentiation?

2010/11 • $13,333 • Scholarship/Fellowship,Other
Though every gene exists within every cell in the body, only a small percentage of genes are activated in any given cell. To manage this genetic information nature has evolved a sophisticated system that facilitates access to specific genes. This system relies on a DNA-packaging complex called...

Patents