Vincent Tabard-Cossa

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Recent Research Projects

Visualizing and Directing Dynamic DNA Nanostructure Assembly With Single-Molecule Resolution

2014/15 • $150,000 • PI,CO
The use of DNA in nanotechnology has become increasingly widespread with far-reaching advantages: these natural nanoscale building blocks are self-assembling, are able to organize species such as drugs, nanoparticles, and other biomolecules, and can store and read information to target specific...

Patents

FABRICATION OF NANOPORES USING HIGH ELECTRIC FIELDS

A method is provided for fabricating a nanopore in a membrane. The method includes: applying an electric potential across the membrane, where value of the electric potential is selected to induce an electric field which causes a leakage current across the membrane; monitoring current flow across the membrane while the electric potential is being applied; detecting an abrupt increase in the leakage current across the membrane; and removing the electric potential across the membrane in...
Related applications: WO2013IB00884, CA20132872602, CA20132872600, EP20130787530, EP20130787530, EP20130787360, EP20130787360, WO2013IB00891, ES20130787530T, ES20130787360T

INTEGRATING NANOPORE SENSORS WITHIN MICROFLUIDIC CHANNEL ARRAYS USING CONTROLLED BREAKDOWN

Nanopore arrays are fabricated by controlled breakdown in solid-state membranes integrated within polydimethylsiloxane (PDMS) microfluidic devices. This technique enables the scalable production of independently addressable nanopores. By confining the electric field within the microfluidic architecture, nanopore fabrication is precisely localized and electrical noise is significantly reduced during sensing.
Related applications: CA20152970627, WO2015IB59799, EP20150869455

LOCALIZING NANOPORE FABRICATION ON A MEMBRANE BY LASER ILLUMINATION DURING CONTROLLED BREAKDOWN

A method for fabricating a nanopore at a particular location in a membrane includes controlling a dielectric strength of the membrane at a particular location on the membrane while applying one of an electric potential or an electric current to the membrane, monitoring an electrical property across the membrane while one of the electric potential or the electric current is being applied across the membrane, detecting an abrupt change in the electrical property across the membrane while one...
Related applications: CA20162976313, WO2016IB51017, EP20160754845

METHODS FOR CREATING FLUIDIC CAVITIES BY TRANSMEMBRANE ETCHING THROUGH POROUS MEMBRANES AND STRUCTURES MADE THEREBY AND USES OF SUCH STRUCTURES

Provided are monolithic structures comprising one or more suspended, nanoporous membranes that are in contact with one or more fiuidic cavities, methods of making same, and exemplary uses of same. The monolithic structures can be formed using a transmembrane etch. The monolithic structures can be used, as examples, as filters and filtration modules in microfluidic devices, dialysis devices, and concentration devices in laboratory, industrial, and medical processes.
Related applications: WO2016US59741

CONTROLLING TRANSLOCATING MOLECULES THROUGH A NANOPORE

To reduce unwanted variation in the speed of DNA translocating solid-state nanopores, a nanoscale pre-confinement of translocating molecules is demonstrated using an ultra-thin nanoporous silicon nitride (NPN) membrane separated from a single sensing nanopore by a nanoscale cavity. Comprehensive experimental results demonstrate that the presence of this nanofilter results in a global minimum in the coefficient of variation of passage times in the sensing pore over a range of DNA sizes which...
Related applications: EP20180789808, WO2018US29939