Stephen Waldman

Contact via Queen's University

Key Research Areas
Associated Researchers
Associated Organizations

Recent Research Projects

NSERC CREATE Training program in Bone and Joint Health Technologies

2010/11-2014/15 • $1,500,000 • PI,CO
The CREATE Professional Research Training Programme in Bone and Joint Health Technologies will provide highly qualified personnel trained in the integration of engineering principles, biological sciences, and information technology to solve patient oriented clinical problems through research...

Chondrocyte mechanotransduction and the purinergic receptor pathway

2010/11-2014/15 • $160,000 • PI
The overall goal of the proposed research program is to investigate the purinergic pathway in the response of cartilage cells to mechanical loading. The application of mechanical loading to tissue engineered cartilage constructs is a widely used method to accelerate tissue growth and enhance...

Canada Research Chair in Engineering of Human Joints

2010/11-2013/14 • $322,658 • PI
No summary

Patient-specific cartilage implants: development and surgical implantation

2012/13-2013/14 • $239,229 • PI,CO
Damage to articular cartilage by arthritis or injury causes significant morbidity as the tissue has little potential for repair. One approach to resurface the damaged area with engineered cartilage. However, as only a limited number of cells can be extracted from a patient, the approach is...

New methods for articular cartilage repair through computer-assisted surgery

2010/11-2012/13 • $161,270 • PI,CO
No summary

Flow cytometer for advanced cell characterization in tissue-engineering applications

2010/11 • $119,278 • PI,CO
The requested flow cytometry system will enable us to advance our research programs and make important progress towards the development of new strategies to promote tissue regeneration in a broad range of applications, including novel orthopaedic, reconstructive, and cardiac therapies. An...

Promotion of cartilage-to-cartilage healing

2010/11 • $86,934 • PI,CO
We are developing an innovative technique to treat osteoarthritis, the debilitating condition wherein loss of mobility results from degeneration of the cartilage in th joint. Currently, there are few surgical approaches available for the repair of these focal cartilage lesions. One of the most...

Advanced tomographic reconstruction

2010/11 • $31,590 • PI,CO
Tomography allow users to obtain three-dimensional (3D) pictures of the internal structure of a material, possibly while it is being deformed under a stress or temperature. Tomographic imaging works by taking multiple two-dimensional (2D) x-ray transmission images of an object; each image...



Bioreactors are useful for cartilage tissue engineering because traditional batch culture is not optimal for cartilage tissue growth. The present invention attempts to maximize diffusive transport to engineered cartilage constructs by replenishing the culture medium in a continuous flow bioreactor. The medium is supplemented to maintain a pH of 7.0 to 7.6 until the construct reaches a size of at least 1.5 square centimetres. Chondrocytes can be directly cultured from a biopsy without a...
Related applications: WO2010CA00231