Alan Davidson

Contact via University of Toronto

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Recent Research Projects

Studies on a Widely Distributed Phage Tail-Derived Toxin Injection System

2017/18-2019/20 • $213,000 • PI
The viruses that infect bacteria (bacteriophages or phages) are the most abundant biological entities on earth. Most phages possess an icosahedral head containing their double-stranded DNA genome and a tail attached to one vertex of the head. The tail is responsible for attaching to the host...



The present disclosure provides compositions and methods for introducing or enhancing Aca activity in prokaryotic cells. The provided compositions and methods can be used to inhibit Acr activity in prokaryotic cells, thereby enhancing endogenous or exogenous CRISPR-Cas activity. Cells, polynucleotides, plasmids, phage, and other elements for practicing the present methods are also provided.
Related applications: WO2020US35403, EP20200812564