Piyush Kumar

Key Research Areas
Associated Researchers
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Recent Research Projects

NSERC CREATE Molecular Imaging Probes training program (CMIP)

2012/13-2015/16 • $1,200,000 • PI,CO
The impact that was felt by the recent shortage of medical isotopes highlighted the importance that molecular imaging and the associated probes has on the health of Canadians and on the economy of Canada. It also demonstrated that there is a need to train a new generation of scientists to...

The CREATE Molecular Imaging Probes Program

2010/11-2011/12 • $450,000 • PI,CO
The impact that was felt by the recent shortage of medical isotopes highlighted the importance that molecular imaging and the associated probes has on the health of Canadians and on the economy of Canada. It also demonstrated that there is a need to train a new generation of scientists to...

Patents

COMPOUNDS USEFUL IN DELIVERING ANTI-NEOPLASTIC THERAPY AND DIAGNOSTIC IMAGING TO HYPOXIC CELLS AND METHODS OF USE THEREOF

Described herein are compounds that permeate cell membranes via specific hypoxia-upregulated transporters in hypoxic cells, get bioreductively activated intracellularly, and bind selectively to subcellular macromolecules to demonstrate hypoxia-specific accumulation in hypoxic cells. Chemically, these compounds are saccharides coupled to bioreductively activated drugs. The compounds have numerous applications in diagnostic imaging and the therapeutic management of hypoxic cells and tissues...
Related applications: WO2009IB07980

COMPOUNDS USEFUL IN IMAGING AND THERAPY

As described herein there is provided novel precursors/synthons, and their chemical and radiochemical derivatives and methods of use thereof.
Related applications: WO2011CA00751

BIOREDUCTIVELY-ACTIVATED COMPOUNDS, THEIR PRODRUGS, RADIOPHARMACEUTICALS, THE COMPOSITIONS, AND THEIR APPLICATIONS IN MULTIMODAL THERANOSTIC MANAGEMENT OF HYPOXIA DISEASES INCLUDING CANCER

Described herein are bioreductively- activated compounds, their prodrugs, radiopharmaceuticals, the compositions, and their application in multimodal theranostic management of hypoxia diseases including cancer.
Related applications: WO2018CA51166, EP20180859438

MARKERS, CONJUGATES, COMPOSITIONS AND METHODS FOR HYPOXIA IMAGING, MAPPING, AND THERAPY

Described herein are markers, conjugates, compositions and methods for hypoxia imaging, mapping, and therapy. A compound comprising bio-reductively activated (BA) arm, linker arm and a mapping click wherein BA contains one for more of substituted or unsubstituted 2/4/5-substituted nitroimidazoles, or substituted benzotriazene-1,4-dioxides, or substituted 1,2,3/1,2,4-triazoles, or substituted 1,4-benzoquinones, or a combination of two homo-or hetero BA moieties, wherein linker arm contains...
Related applications: WO2018CA51165

THERANOSTIC RADIOPHOTODYNAMIC THERAPY NANOPARTICLES

A nanoparticle includes a nanocarrier encapsulating a nanoscintillator capable of emitting light upon exposure to radiation; a photosensitizer capable of absorbing the light from the nanoscintillator to generate singlet oxygen species; and optionally, one or more diagnostic agents, therapeutic agents, or a combination thereof.
Related applications: WO2019CA50866