Lori Burrows

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Recent Research Projects

Integrated liquid chromatography-multiangle light scattering system to measure absolute masses and stoichiometries of biological assemblies in solution

2018/19 • $149,899 • PI,CO
This application requests a state-of-the-art size exclusion chromatography system integrated with multi-angle light scattering (SEC-MALS). SEC-MALS is capable of measuring absolute aggregate molecular weights (MWs) and radii of gyration (Rg) under physiological native solution conditions with...

Agents Provocateur: Exploiting bacterial biofilm stimulation to identify bioactive small molecules

2016/17-2018/19 • $114,000 • PI
Most bacteria grow as surface-associated biofilms, with reduced susceptibility to antibiotics and disinfectants. Biofilms are important in industrial, agricultural, and medical settings, prompting searches for ways to modulate their formation. While searching for biofilm inhibitors, we...

Role of peptidoglycan-active enzymes in the assembly of bacterial motility, secretion and efflux systems

2011/12-2015/16 • $280,000 • PI
Peptidoglycan (PG) is a major structural component of bacterial cell walls but is absent in higher organisms. It is a strong, chain link fence-like material with a pore size of ~100 kDa. It completely surrounds bacteria, providing protection against high internal pressures and contributing to...

Patents

ANTI-BACTERIAL COMBINATION THERAPY

Provided herein in aspects is an antibacterial combination comprising a thiopeptide antibiotic and an iron inhibitor. Methods of treatment and/or prevention of bacterial infections using the combination are also provided as well as methods of sensitizing a gram-negative bacteria to a thiopeptide antibiotic and methods of screening a molecule for antimicrobial activity.
Related applications: WO2020CA50247