Harry Brumer

Key Research Areas
Associated Researchers
Associated Organizations

Recent Research Projects

Ecosystem Services, Commercialization and Entrepreneurship (ECOSCOPE)

2015/16-2019/20 • $1,248,148 • PI,CO
Microorganisms represent the invisible majority of living things on Earth. Interconnected microbial communities catalyze matter and energy conversion processes essential to ecosystem services through networks of metabolite exchange. The concept of community metabolism has recently emerged as a...

Discovery, characterization, and application of carbohydrate-active enzymes from diverse biological niches

2018/19-2019/20 • $196,000 • PI
The enzymatic synthesis and degradation of complex carbohydrates ranks among the most important biocatalytic processes in Nature. Thus, illuminating the catalytic diversity of carbohydrate-active enzymes (CAZymes), as well as the specificity of associated carbohydrate-binding and...

Detecting Trace Metals in Synthetic and Biological Macromolecules. ICPMS for a Multi-User Facility in Chemistry

2019/20 • $150,000 • PI,CO
This proposal requests funding for an inductively coupled plasma mass spectrometer (ICPMS) to be installed in the Department of Chemistry at UBC. The instrument will be used to measure the presence of metals in a variety of samples, at so-called trace or ultra-trace levels. Trace concentrations...

NSERC Industrial Biocatalysis Network

2014/15-2018/19 • $5,150,000 • PI,CO
Oil and gas are converted to plastics, chemicals, and other industrial and consumer products through energy-intensive manufacturing processes. These products would be more environmentally sustainable if they were made from renewable resources, such as agricultural and forestry waste, and if they...

Molecular mechanisms of complex dietary carbohydrate metabolism by the human gut microbiota

2015/16-2018/19 • $603,991 • PI
The human gut is colonized by a vast population of microorganisms, known collectively as the microbiota. When in balance, this complex ecosystem positively affects human health by enabling us to obtain energy from the otherwise indigestible complex carbohydrates known as "dietary fibre", while...

ANR-FUNTASTIC - Fungal copper-radical oxidases as new biocatalysts for the valorization of biomass**carbohydrates and alcohols

2018/19 • $242,000 • PI,CO
Terrestrial plant biomass, in the form of agricultural crops and forest materials, constitutes one of Canada's most important and abundant natural resources. Indeed, Canada's forests are iconic, and the forest products industry has long been a major contributor to the national gross domestic...

Biorefining of novel cellulosics from forest fibre resources

2015/16-2017/18 • $532,812 • PI
The forest products industry is a key contributor to Canada's gross domestic product (GDP). This contribution has been in decline for the past decade owing to a challenging global export economy and changing consumer needs for newsprint and other paper products made from wood pulp fibre. To stem...

Discovery, characterization, and application of carbohydrate-active enzymes from diverse biological niches

2013/14-2017/18 • $290,000 • PI
The enzymatic synthesis and degradation of complex carbohydrates arguably ranks as one of the most important biocatalytic processes in Nature: Plant and algal cell walls, which are predominantly comprised of polysaccharides, constitute an enormous reservoir in the global carbon cycle (ca. 2000...

ANR-FUNTASTIC - Fungal copper-radical oxidases as new biocatalysts for the valorization of biomass carbohydrates and alcohols

2017/18 • $239,000 • PI,CO
Terrestrial plant biomass, in the form of agricultural crops and forest materials, constitutes one of Canada's most important and abundant natural resources. Indeed, Canada's forests are iconic, and the forest products industry has long been a major contributor to the national gross domestic...

FUNTASTIC - Fungal copper-radical oxidases as new biocatalysts for the valorization of biomasscarbohydrates and alcohols

2016/17 • $209,000 • PI,CO
Terrestrial plant biomass, in the form of agricultural crops and forest materials, constitutes one of Canada's most important and abundant natural resources. Indeed, Canada's forests are iconic, and the forest products industry has long been a major contributor to the national gross domestic...

400MHZ BROADBAND INVERSE DETECTION NMR SPECTROMETER

2016/17 • $150,000 • PI,CO
We propose to urgently upgrade the console and the probe of our 400 MHz broadband inverse detection NMR spectrometer (AV400inv) in the Departmental NMR facility at the University of British Columbia. This multiuser facility is accessed by over 20 research groups and more than 250 HQP are trained...

Polysaccharide functionalization for medical device applications

2016/17 • $12,500 • PI
Inter-tissue adhesions cause significant complications following veterinary surgery of domesticated animals.Fucoidans are natural, negatively charged, carbohydrate polymers (polysaccharides) from seaweeds that havebeen successfully developed and commercialized for reducing such adhesions,...

NSERC Green Fibre Network

2010/11-2014/15 • $6,163,569 • PI,CO
The Canadian Forest Industry is struggling for its survival. Traditional markets of printing grades, the major part of Canadian Pulp and Paper Production, are dwindling and are unlikely to regain profitability in the future. For a renewal of the Canadian Forest Industry, revolutionary changes...

Molecular mechanisms of complex dietary carbohydrate metabolism by the human gut microbiota

2014/15 • $100,000 • PI
The human gut is colonized by a vast population of microorganisms, known collectively as the microbiota. When in balance, this complex ecosystem positively affects human health by enabling us to obtain energy from the otherwise indigestible complex carbohydrates known as "dietary fibre", while...

Analysing Macromolecular Binding at Biological Surfaces by Surface Plasmon Resonance

2013/14 • $150,000 • PI,CO
The cell surface is the major interaction region between cells their environment. Cells construct barriers to prevent physical and chemical damage and to mediate the flow of nutrients and waste. All cells have a lipid membrane barrier, and in many cases, a cell wall constructed of peptidoglycan...

Upgrade to UBC-Chemistry Departmental NMR Facility

2013/14 • $150,000 • PI,CO
The UBC-Chemistry Nuclear Magnetic Resonance (NMR) Facility is the only facility on campus that is open to chemistry faculty and students for regular NMR analysis. This facility is critical to the success and training of ca. 250 chemistry trainees at the undergraduate, graduate and postdoctoral...

Patents

XYLOGLUCAN-CONTAINING PRODRUGS AND METHODS OF MANUFACTURE AND USE THEREOF

The present application provides compounds, compositions and methods to reduce, alleviate or treat various enteric diseases and disorders, such as inflammatory bowel disease. The compounds are xyloglucan-containing prodrugs, referred to herein as glyco-caged prodrugs, of formula (I) or (II), xyloglucan-β-O-RD (I), xyloglucan-β-O-LSI-RD (II).
Related applications: WO2020CA50447