Brian Wilson

Key Research Areas
Associated Researchers
Associated Organizations

Recent Research Projects

Development and clinical translation of a Raman spectroscopy imaging technique to increase the extent of tumor resection in glioma surgery

2016/17-2017/18 • $264,929 • PI,CO
Gliomas constitute 80% of all malignant brain tumors and are one of the most fatal of all cancers. For example, the mostaggressive form (glioblastoma) is associated with a mean survival of only 14 months. The standard treatment for braincancer involves surgical tissue resection where the...

Real-time intraoperative spectroscopic tumor margin detection in robotic-assisted radical prostatectomy on prostate cancer patients

2016/17-2017/18 • $86,200 • PI,CO
Surgical removal of the tumor is the front-line therapy and successful patient outcomes rely on removing the most cancer cells possible. ODS Medical's has developed an intra-operative system that uses a hand-held probe to pinpoint cancerous tissue for removal past the margins identified by...

Nonlinear Optical Imaging for Digital Pathology

2014/15-2016/17 • $425,394 • PI,CO
This project will develop a novel approach to improve histopathology, using multiple nonlinear light-tissue interactions thatoccur when intense but very short pulses of laser light (less than one billionth of a second) are used. These interactionsprovide novel mechanisms for image contrast in...

Optical guidance for safe and effective brain tumor biopsy

2014/15-2016/17 • $211,407 • PI,CO
Brain tumor treatment often involves open-cranium surgery to achieve maximum resection and provide survival benefits.However this is not always the best treatment option and the decision whether or not to proceed with surgery is informed bythe suspected type and grade of the tumor, as well as by...

BiopSys: NSERC Strategic Network for Bioplasmonic Systems

2010/11-2013/14 • $3,483,630 • PI,CO
The aim of the NSERC Strategic Network for Bioplasmonic Systems (BiopSys) is to shorten the time needed for diagnosis and improve prognosis for cancers, such as lung cancer and leukemia, by incorporating plasmonics into diagnostic platforms. Plasmonics is an enabling technology based on an...

Non-linear multimodal mircoendoscopy for lung cancer pathology

2012/13-2013/14 • $265,500 • PI,CO
Lung cancer is the leading cause (~28%) of cancer-related deaths. This proposal addresses two major challenges in the management of individuals at high-risk for lung cancer: A) differential diagnosis of peripheral lung lesions, and B) detection of dysplastic lesions in the central bronchus....

Ultrasound and MRI guided interstitial optical coherence tomography

2010/11-2012/13 • $421,250 • PI,CO
PROBLEM: Current biopsy techniques for cancer utilize external guidance, which only provides approximate positioning information for the placement of biopsy needles without sufficient resolution to verify the accuracy of obtaining a core biopsy that contains cancerous tissue. Key deficiencies in...



Devices, materials, compounds, systems, and processes for Cherenkov-Activated Nuclear-Targeted Photodynamic Therapy that involves generating Cherenkov light within the tissue of a target volume and using this light to activate photosensitizing material that is located in the nucleus of cells of the target volume.
Related applications: EP20170798468, WO2017CA50614