Alexei Savchenko

Contact via University of Toronto

Key Research Areas
Associated Researchers
Associated Organizations

Recent Research Projects

NSERC Industrial Biocatalysis Network

2014/15-2018/19 • $5,150,000 • PI,CO
Oil and gas are converted to plastics, chemicals, and other industrial and consumer products through energy-intensive manufacturing processes. These products would be more environmentally sustainable if they were made from renewable resources, such as agricultural and forestry waste, and if they...

Overcoming antibiotic resistance through the inhibition of aminoglycoside phosphotransferases (APH).

2013/14-2014/15 • $169,101 • PI,CO
Multidrug resistant microbes have become one of the top global health challenges and place a massive burden on theCanadian health care system. One approach to overcome this problem involves inhibiting the enzymes responsible forconferring resistance to the antibiotic. We have recently discovered...

Molecular mechanisms of the CRISPR-based microbial defense system

2010/11-2014/15 • $165,000 • PI,CO
Lay Title: A novel mechanism of genome protection in microbesLay AbstractMicrobial cells have developed and are continuously developing numerous defence mechanisms to protect themselves from various antimicrobial factors. Bioinformatic analyses of sequenced microbial genomes have identified a...

Core facility infrastructure for optimizing conditions for lipidic cubic phase-based membrane protein crystallization

2014/15 • $150,000 • PI,CO
Membrane proteins perform a variety of biological functions that are critical to the survival of bacteria, plants, and eukaryotes. Crystal structures of these membrane proteins have shed enormous insights into the functions of transporters, signal transduction receptors, and enzymes. However,...

Examining Biomolecular Interactions using Microscale Thermophoresis

2013/14 • $150,000 • PI,CO
As part of a team of 10 structural biologists at the University of Toronto (spanning several departments and faculties), we use biophysical tools such as Atomic Force Microscopy, NMR spectroscopy, X- ray crystallography and electron cryomicroscopy to analyze the biomolecular interactions between...

High throughput culturing system for evolutionary engineering

2010/11 • $126,760 • PI,CO
The genomics revolution has provided an unprecedented opportunity to apply biotechnology for the solution of a range of practical problems including 1) efficient extraction of metals from sulfide minerals with minimal environmental impact, 2) identification and characterization of novel enzymes...