Yves De Koninck


Contact via Laval University


Key Research Areas
Associated Researchers
Associated Organizations

Recent Research Projects

Chronic pain and related brain disorders

2015/16-2019/20 • $850,000 • PI
Uncontrolled pain continues to be the single most common cause of disability that impairs the quality of life. It remains difficult to treat; complete pain control is rarely achieved and disabling side effects are frequent. Persistent, untreated pain is associated with several brain disorders,...

Unraveling sensory coding dysfunctions that underlie chronic pain

2018/19-2019/20 • $512,255 • PI
Intractable pain continues to be the single most common cause of disability that impairs quality of life. Unfortunately, current pain treatments rarely achieve complete pain control, and are often associated with disabling side effects. This is concerning, since persistent untreated pain is...

Genetic analysis of spinothalamic neuron function in nociception

2017/18-2019/20 • $486,540 • PI,CO
Pain is essential for our survival but diseases affecting it leave many Canadians suffering from chronic pain. Pain sensation is poorly understood and we are still struggling with very simple questions like how is pain in our bodies relayed to our brains. Many previous studies demonstrate that...

Chloride dysregulation and neuropathic pain: Linking molecular mechanisms with altered pain processing via identification of cellular and circuit level changes

2017/18-2019/20 • $394,477 • PI,CO
Imagine gentle touch causing excruciating pain. Such pathological pain develops in up to 1 in 15 people because of insults to the nervous system. Despite identification of many "pain" molecules, so-called neuropathic pain remains hard to treat. The slow pace of developing better pain medications...

Smart, adaptive, and autonomous sensing

2019/20 • $300,000 • PI,CO
adaptive,autonomous,environment,mental health,multimodality,nutrition,optical sensing,real-time,smart

Muscarinic receptor antagonism as a novel mechanism for sensory nerve repair

2019/20 • $218,025 • PI,CO
Objective Diabetic sensory neuropathy and chemotherapy-induced peripheral neuropathy (CIPN) are neurodegenerative diseases characterized by loss of nerve fibers in the skin. Both diseases cause significant pain and eventually lead to sensory loss. The impact of these diseases on human health is...

Inhibitory synaptic pruning as a substrate of neuropathic pain

2019/20 • $100,000 • PI,CO
Chronic pain does not serve any useful purpose and is now considered a disease by itself. Unfortunately, it is often poorly managed in the clinic as we still have a limited knowledge of what causes it. Neuropathic pain is a form of chronic pain that sometimes appears after lesions to nerves and...

A prospective translational model of the therapeutic potential of cannabidiol in reducing acute pain symptoms and opioid usage following traumatic injury.

2019/20 • $74,996 • PI
Recreational cannabis is legal in Canada since October 2018. Based on Colorado's experience, the first U.S. state to have legalized recreational cannabis in 2014, effects on Canadians' health are to be expected including: 1) increased recreational cannabis use; and 2) increased risk of traumatic...

Plasticity of inhibition in spinal sensory pathways

2014/15-2018/19 • $1,205,494 • PI
The nerve cells of the sensory portion of the spinal cord in humans and animals are responsible for the relay of pain related information from the body to the brain, leading to a perceived sensation. Injury to the nervous system can induce persistent changes in spinal cord function that cause...

Smart, adaptive and autonomous sensing

2017/18-2018/19 • $450,000 • PI,CO
No summary

Minimally-invasive, wireless, multimodal micro-optrodes for brain sensing

2015/16-2017/18 • $375,000 • PI,Other
The proposed 3-year research project relates to the rapid convergence of Fiber optics, Wireless technology, and Neurological sciences to the study of brain activity. The project aims to combine the complementary expertise of physics, neurobiology, and electrical engineering of three leading...

Large-scale, high-resolution light-sheet microscope for whole brain connectomics

2015/16-2017/18 • $326,994 • PI
To break the mysteries of the normal and diseased brain we must be able to visualize the very complex circuitry of the brain with high resolution (thousandths of millimeters). This can be achieved with light microscopy which offers high resolution but also the ability to visualize wide areas at...

Innovative systems for smart multimodal optoelectronic sensors integration

2017/18 • $150,000 • PI,CO
This program will develop new ground breaking approaches to provide neuroscience research with novel smart wireless experimental tools. In particular, this research will contribute to sought new innovative methods to increase systems intelligence and functionality while pushing miniaturization...

Minimally-invasive, wireless, multimodal micro-optrodes for brain sensing

2015/16-2016/17 • $375,000 • PI,CO
The proposed 3-year research project relates to the rapid convergence of Fiber optics, Wireless technology, andNeurological sciences to the study of brain activity. The project aims to combine the complementary expertise of physics,neurobiology, and electrical engineering of three leading...

Sensing and modulating neuronal activity from the spinal epidural space with optical fibers

2014/15-2016/17 • $357,982 • PI,CO
Optical techniques offer the spatial resolution and the contrast necessary to locate and measure neuronal activity. We havedeveloped optical fiber technology for creating miniature micro-optical devices by leveraging many standard practices fromthe telecommunication industry which can serve as...

Sensing and modulating neuronal activity from the spinal epidural space with optical fibers

2014/15-2016/17 • $357,982 • PI,CO
Optical techniques offer the spatial resolution and the contrast necessary to locate and measure neuronal activity. We have developed optical fiber technology for creating miniature micro-optical devices by leveraging many standard practices from the telecommunication industry which can serve as...

In vivo identification of microlesions in multiple sclerosis: a new tool for quantification of disease aetiology and treatment efficacy

2010/11-2015/16 • $2,518,375 • PI
The global objective of this project is to develop an in vivo measurement strategy for large-scale monitoring of microlesions that are below the detection limits of magnetic resonance imaging, and identify biomarkers in the pathology of multiple sclerosis that can be used to assess structural...

NSERC CREATE Training Program in Biophotonics

2010/11-2015/16 • $1,646,225 • PI,CO
The future of progress in Life Sciences, from understanding basic biochemistry to complex biological organisms and environmental issues, hinges critically on our ability to improve our ways to study and manipulate molecules and living organisms with increased precision and reduced invasiveness....

Neurophysics CIHR Training Grant

2010/11-2014/15 • $1,643,750 • PI,CO
This proposal is for the renewal of our Training Program at the interface between Neurosciences, Photonics, the Nanotechnologies and Computational sciences. The objective of this training program is to create a generation of Health Scientists with a truly transdisciplinary attitude and ability...

Muscarinic receptor antagonism as a novel mechanism for sensory nerve repair.

2012/13-2014/15 • $111,078 • PI,CO
Objective Diabetic sensory neuropathy and chemotherapy-induced peripheral neuropathy (CIPN) are neurodegenerative diseases characterized by loss of nerve fibers in the skin. Both diseases cause significant pain and eventually lead to sensory loss. The impact of these diseases on human health is...

Plasticity of inhibition in spinal sensory pathways

2010/11-2013/14 • $1,119,365 • PI
The nerve cells of the sensory portion of the spinal cord in humans and animals are responsible for the relay of pain related information from the body to the brain, leading to a perceived sensation. Injury to the nervous system can induce persistent changes in spinal cord function that cause...

Rôles des voies spinales de la nociception dans les douleurs chroniques

2010/11-2012/13 • $95,000 • Scholarship/Fellowship,Other
Les douleurs neuropathiques sont des douleurs qui sont associees a une lesion du systeme nerveux. Un des substrats important de ce type de douleurs est un traitement aberrant de l'information sensorielle au niveau de la moelle epiniere. Les mecanismes qui sous-tendent ce traitement anormal des...

Synaptic Circuitry in the Dorsal Horn of the Spinal Cord in Normal Rats and in a Model of Neuropathic Pain

2010/11 • $17,500 • Scholarship/Fellowship,Other
Neuropathic pain is a chronic, debilitating disease to which there is no cure. This condition usually follows lesions to peripheral nerves and can lead to decades of intense pain in the absence of any overt tissue damage. What renders neuropathic pain such a challenge in the clinical setting is...

Imaging Pain: from Cells to Brains; Official Satellite Symposium of the 13th World Congress on Pain

2010/11 • $10,000 • PI
Revolutions in imaging techniques have occurred at multiple length scales, offering a wide range of new modalities to probe living tissue and thus opening new perspectives for the understanding of every aspects of pain-related mechanisms, from unraveling how ion channels transduce information...

2010 Canadian Neuroscience Meeting

2010/11 • $7,250 • PI
This is the 5th annual Canadian Neuroscience meeting that is organized by the Canadian Association for Neuroscience. The meeting has been held in Toronto, Montreal, Vancouver, Ottawa and now this year the meeting will be held in Quebec City. The meeting consists of 3 days with plenary lectures,...

Functional regulation of KCC2 in dorsal horn neurons

2010/11 • $3,333 • Scholarship/Fellowship,Other
In North America, back pain is the primary reason for a person to miss work and the second for a person to visit a doctor. This pain message is encoded at the level of the spinal cord and transmitted to the brain. The regulation of the pain in the spinal cord is still not clear, but pain...

Patents

CNS chloride modulation and uses thereof

Methods and products for the attenuation or treatment of pain and the reduction of nociception are described. The methods and products are based on the modulation of CNS intracellular chloride levels. The methods and products may also relate to modulation of the activity and/or expression of a chloride transporter, such as the KCC2 potassium-chloride cotransporter. Also described herein are commercial packages and uses based on such modulation. Related methods for identifying or...
Related applications: EP20040732907, EP20090172724, WO2004CA00726, AT20040732907T, CA20042524883

METHOD AND SYSTEM FOR IMPROVING RESOLUTION IN LASER IMAGING MICROSCOPY

A method and a system for obtaining a high-resolution image of a volume of a sample using laser imaging are provided. The method includes a step of probing the volume of the sample with a first excitation beam having an intensity profile of maximum intensity at a center thereof, thereby obtaining a positive image of the volume. The method also includes a step of probing the volume of the sample with a second excitation beam having an intensity profile of minimum intensity at a center thereof...
Related applications: WO2012CA50794, CA20122854675, EP20120848742

METHOD AND SYSTEM FOR IMPROVING LATERAL RESOLUTION IN OPTICAL SCANNING MICROSCOPY

A method and system for improving lateral resolution in optical microscopy are provided. The method includes generating a source optical beam and passing the source optical beam successively through an axicon, a Fourier-transform lens and an objective to convert the source optical beam into an excitation Bessel-type beam having a central lobe and at least one side lobe. The method also includes focusing the excitation beam onto a focal plane of the objective within or on a sample to generate...
Related applications: WO2017CA50195, EP20170752599, CA20173013946