Recent Research Projects

The role of E-cadherin in regulating signalling pathways

2019/20 • $32,000 • PI
Novelty, research program and short-term goal E-cadherin exhibits broad biological functions and is crucial during embryonic development, reprogramming of adult cells to embryonic stem-like cells and adult tissue maintenance/homeostasis. While the majority of studies thus far focus on how growth...

Alterations of Wnt, Akt and Yap signalling during bi-directional epithelial-mesenchymal transitions

2017/18 • $28,000 • PI
Novelty, research program and short-term goal Bi-directional epithelial-mesenchymal transitions (EMT/MET) are fundamental cellular processes essential for normal mammalian embryonic development and adult cell homeostasis and functions. While the majority of studies thus far focus on how growth...

Hematopoietic transcription factors and their role in leukemogenesis

2011/12-2016/17 • $800,690 • PI,CO
Acute Myeloid Leukemia (AML) is the most common form of leukemia in adults, yet it has the lowest survival rate with less than 30% of adult patients reaching complete remission. Even patients achieving pathologic complete remission after chemotherapy and bone-marrow transplant will almost...

Molecular Mechanism of Self-renewal and Mesoderm Development of Human Pluripotent Stem Cells

2011/12-2015/16 • $693,190 • PI
Embryonic stem (ES) cells hold strong therapeutic promises. To realize their application potentials, it is essential to understand what makes them self-renew (unlimited division) and what drives them to differentiate (becoming adult tissues for cell-based therapy). Our current studies suggest...

Single cell analysis of nurturing of the human embryonic stem cells

2010/11-2012/13 • $165,000 • PI
Human embryonic stem cells (hESCs) can theoretically divide without limit and can grow into almost any type of cell, providing a novel model to better understand early human embryonic development that cannot be well examined in other human based systems. hESCs also hold strong potential to...

Molecular Mechanism of Self-renewal and Mesoderm Development of Human Pluripotent Stem Cells

2011/12 • $1,000 • PI
Embryonic stem (ES) cells hold strong therapeutic promises. To realize their application potentials, it is essential to understand what makes them self-renew (unlimited division) and what drives them to differentiate (becoming adult tissues for cell-based therapy). Our current studies suggest...

Patents