Hasan Uludag


Contact via University of Alberta


Key Research Areas
Associated Researchers
Associated Organizations

Recent Research Projects

siRNA Therapy for Leukemia: Synthetic Biomaterials to Deliver siRNA and Curb Uncontrolled Growth of Leukemic Cells

2015/16-2019/20 • $578,295 • PI,CO
Leukemias are a significant cause of death among cancer patients. Great strides have been made in understanding the factors causing leukemia and numerous new types of drugs are being continuously explored for therapy. However, the traditional chemotherapy is still the treatment of choice for...

Engineering Biomimetic Gene Activated Matrices for Bone Tissue Regeneration

2018/19-2019/20 • $252,450 • PI,CO
Gene therapy offers the promise of a fast and permanent cure for a wide range of bone disorders. The ability to repair bone with gene medicines requires stimulating deposition of new tissue with therapeutic genes. In conjunction, implantable scaffolds should provide suitable environment to...

Engineering Effective Polymers to Enable Gene Based Therapies

2019/20 • $55,000 • PI
Molecular therapy utilizing nucleic acids offers an exciting approach over conventional drugs. Diseased organs can be better restored to normal state with the use of gene-based medicines derived from nucleic acids. The success, however, is absolutely dependent on the use of nucleic acid...

Tailored Polymers for Delivery of Gene Medicines

2014/15-2018/19 • $145,000 • PI
Molecular therapy offers the best promise of a cure for a wide range of genetic disorders. The ability to permanently ‘fix’ defective genes is desirable over current drug therapy, which typically do little to eradicate the underlying cause of the disease. Successful molecular therapy involves a...

Ultrasound technology to improve transfection of human cells

2018/19 • $25,000 • PI
Nucleic acid delivery to human cells (so called transfection) is a widely practiced in biomedical research industry and clinical therapy. Human cells are especially resistant to delivery of nucleic acids due to active mechanisms to resist the intake of foreign genetic material. Chemical methods...

Knee Meniscus Reconstruction Using Mesenchymal Stem Cells

2012/13-2017/18 • $696,183 • PI,CO
Meniscus injury is a major risk factor for the development of osteoarthritis, a disease characterized by erosion of knee joint cartilage. Injury to the meniscus is one of the most common knee joint problems and as long as hockey, basketball, soccer and skiing remain popular pastimes in Canada,...

Technology To Improve the Robustness of Diagnostic Assays

2017/18 • $25,000 • PI
Minimally invasive diagnostic analyses that do not require tissue sampling is a desirable approach for detectionof wide range of diseases, including invasive pathogens. RNA-based biomarkers from these pathogens arereleased to the bloodstream and become part of the cell free RNA pool in blood,...

NSERC CREATE Program on Regenerative Medicine

2011/12-2016/17 • $1,520,000 • PI,CO
This NSERC CREATE program for regenerative medicine (NCPRM) aims to provide multi/trandisciplinary formation to highly qualified personnnel to support the field of regenerative medicine in Canada, by giving access to graduate students to state-of-the-art expertise and diversified resources,...

Designing Amphiphilic Polymeric Carriers of DNA for Gene Therapy

2012/13-2015/16 • $513,029 • PI,CO
Gene therapy offers the promise of a permanent cure for a wide range of disorders. The ability to permanently replace defective or missing genes is desirable over the current pharmacological interventions, which typically treat the disease symptoms but do little to eradicate the underlying...

A New Approach for Acute Myeloid Leukemia Treatment: siRNA Nanoparticles to Turn-Off Infinite Proliferation and Evasion of Apoptosis

2012/13-2014/15 • $105,000 • Scholarship/Fellowship,Other
Acute Myeloid Leukemia (AML) is caused by uncontrolled growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. AML is initially treated with chemotherapy but the drug therapy is not curative at the advanced stage of the...

Nanodelivery Systems for Modulation of Chemotherapy Response in Invasive and Metastatic Breast Cancer

2014/15 • $100,000 • PI,CO
Chemotherapy is still the treatment of choice in breast cancer, but it is not curative. Intolerable toxicities emerge after intensive chemotherapy because of their non-specific distribution/action in normal tissues. The side effects of chemotherapy can also force clinicians to use sub-optimal...

Engineering biodegradable polymers for gene delivery

2010/11-2013/14 • $92,000 • PI
Gene therapy is a powerful approach to treatment of several important diseases since it can address the root cause of the problem rather than alleviate the disease symptoms that are typical with current drugs. For a successful gene therapy procedure, it is necessary to use specific delivery...

Tissue Engineering Therapies for Bone Regeneration in Cleft Palates

2011/12-2013/14 • $84,334 • Scholarship/Fellowship,Other
Cleft palate is a congenital defect which develops due to a combination of genetics and environmental factors and occurs in 1.7 per 1000 live born infants worldwide. Infants with cleft palates have an opening in the roof of the upper jaws where the two sides of the hard palate did not fuse...

Development and Application of Non-Rejectable Allogenic Skin Substitute as a Wound Coverage

2010/11-2012/13 • $544,968 • PI,CO
Large and severe thermal injuries cause non-healing and over healing wounds which constitute a considerable and unfortunate complication for millions of patients whose wounds remain open for a prolonged duration (more than 4 weeks). This delay in wound closure can lead to infection as well as...

A Digital PCR for Biomedical Engineering Research

2012/13 • $79,600 • PI,CO
Probing mechanisms of action and improving the performance of therapeutic agents are indispensable part of developing new and innovative therapeutic interventions. Evaluating the performance of therapeutic agents with polymerase chain reaction (PCR) is ideal in genetic therapies since it is cost...

Direct Non-Viral Gene Delivery for Bone Regeneration

2011/12-2012/13 • $70,000 • Scholarship/Fellowship,Other
Up to 10-20% of fractures are associated with impaired healing. The current gold standard method is an autologous bone graft, where the patient's own bone tissue is harvested from a second site, such as the iliac crest, and used to repair the defect. Even if the quantity and quality of harvested...

Stem cells as promoters of skeletal repair

2010/11-2011/12 • $554,750 • PI,CO
Embryonic stem cells offer a potential endless supply of cells for the therapeutic restoration of degenerative disorders including skeleton. Based on current orthopedic practice, which is focused on the use of materials to repair bone and cartilage, the skeleton appears to be a ripe target for...

Designing Amphiphilic Polymeric Carriers of DNA for Gene Therapy

2010/11-2011/12 • $283,510 • PI,CO
Gene therapy offers the promise of a permanent cure for a wide range of disorders. The ability to permanently replace defective or missing genes is desirable over the current pharmacological interventions, which typically treat the disease symptoms but do little to eradicate the underlying...

Regenerative therapy for the intervertebral disc

2010/11-2011/12 • $95,348 • PI,CO
Intervertebral disc-related low back pain is one of the most significant orthopaedic disorders in industrialized society, costing the U.S. economy some $50-100 billion annually, with comparable per capita costs to the Canadian economy. Despite the economic burden of intervertebral disc (IVD)...

Fluorescence lifetime imaging and fluorescence polarization for elucidation of molecular level events: peptide self-assembly, NP dissassembly in cells, and phage binding.

2011/12 • $86,288 • PI,CO
Fluorescence based tools are a cost effective means (compared to pulsed nMR which is the only technique that can provide similar information) of elucidating molecular level events. This is primarily due to the wealth of information that can be obtained from fluorescence emission, which can be...

Development and application of a non-rejectable engraftment of allogeneic pancreatic islets populated collagen-GAG gel in diabetic animal model

2010/11 • $116,254 • PI,CO
Diabetes mellitus is a chronic disease, which causes long-term problems in patients¿ kidneys, heart, eyes, nerves, feet and almost all other organs. The only treatment currently available for type 1 diabetic patients is that based on repeated daily injections of insulin. However, despite...

A small animal imager for drug delivery and tissue engineering research

2010/11 • $87,000 • PI,CO
Probing the mechanism of action and improving the performance of therapeutic agents in animals are indispensable parts of developing new and innovative therapeutic interventions. Evaluating the performance of therapeutic agents in small animals is ideal in an academic setting since it is cost...

Regenerative therapy for the intervertebral disc

2010/11 • $69,493 • PI,CO
Intervertebral disc-related low back pain is one of the most significant orthopaedic disorders in industrialized society, costing the U.S. economy some $50-100 billion annually, with comparable per capita costs to the Canadian economy. Despite the economic burden of intervertebral disc (IVD)...

Development of Artificial Virus-like Particles for creating induced pluripotent stem cells for use in osteoporosis therapy.

2010/11 • $17,500 • Scholarship/Fellowship,Other
The ability to make embryonic-like stem cells from a patient's own cells will revolutionize medicine creating a multitude of regenerative cell-based therapies. Contrary to ES cells isolated from developing embryos, these cells carry the advantage of having the same genetic makeup as the patient...

Patents