Tuan Trang


Contact via University of Calgary


Key Research Areas
Associated Researchers
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Recent Research Projects

Central and peripheral determinants of acute and persistent joint pain

2016/17-2019/20 • $393,716 • PI,CO
Pain with motion, pain at rest, pain at night, sharp pain, dull pain-pain is highly variable among and within those afflicted with arthritis. Much is now known about joint tissue changes in arthritis, but only a little is known about how pain that begins in the joint makes its way to the spinal...

Role of neuroinflammation in the development of chronic joint pain

2016/17-2019/20 • $378,429 • PI,CO
Chronic joint pain is a common cause of disability that is difficult to treat effectively and is poorly understood. The symptoms of chronic pain reported by arthritis patients closely resemble those reported by patients with nerve injuries. This suggests that arthritis pain might be caused, at...

Mechanisms of opioid analgesia in the central nervous system

2014/15-2019/20 • $300,000 • PI
Chronic pain is pervasive, insidious, and afflicts 1 in 5 adult Canadians. Treating pain in these individuals is notoriously difficult and often requires opioids, one of the most powerful and effective classes of drugs used for controlling pain. However, a major problem with opioid use is the...

Regulation of microglial pannexin-1 channels in arthritis pain

2019/20 • $175,185 • PI,CO
Pain is a key feature of arthritis, a disease of the joint and a leading cause of disability in both young and old. Despite recent advances in treating joint inflammation, and the widespread use of pain medications by arthritis patients, adequate pain control is an ongoing and challenging health...

Central mechanisms of opioid withdrawal

2019/20 • $100,000 • PI,CO
Opioid medications provide potent pain relief in the short-term, but their long-term use can cause serious adverse effects. A major problem is that chronic opioid users experience debilitating withdrawal symptoms when attempting to stop or reduce their opioid medications. In an attempt to curb...

The Biology of Microglia: Adenosine A3 Receptor Suppression

2019/20 • $40,000 • PI
Microglia are immune cells that reside within the confines of the brain and spinal cord. Previously assumed to be merely support cells for neurons, it is now clear that microglia have many important roles: they are sculptors that shape the cellular architecture of the developing and mature...

The role of VGLUT1 expressing proprioceptive afferents on exercise-induced pain and motor recovery following peripheral nerve injuries

2019/20 • $21,667 • Scholarship/Fellowship,Other
Neuropathic pain is a debilitating chronic pain condition, caused by injuries to the nervous system and impacts 7 to 8% of the global population. Individual differences in pain tolerance, and the diverse cause of nerve injuries including trauma, sport injuries, inflammation, and chemotherapy,...

Mechanisms of opioid analgesia in the central nervous system.

2014/15-2018/19 • $684,055 • PI
Chronic pain is pervasive, insidious, and afflicts 1 in 5 adult Canadians. Treating pain in these individuals is notoriously difficult and often requires opioids, one of the most powerful and effective classes of drugs used for controlling pain. However, a major problem with opioid use is the...

Targeting microglial Panx1 to treat the adverse effects of repeated opioid use

2017/18-2018/19 • $105,000 • Scholarship/Fellowship,Other
Chronic pain is pervasive, insidious, and afflicts 1 in 5 Canadians. Treating chronic pain is notoriously difficult and often requires opioids, one of the most powerful and effective classes of drugs used for managing pain. While opioids are potent analgesics for relieving moderate to severe...

Regulation of microglial pannexin-1 channels in arthritis pain

2018/19 • $100,000 • PI,CO
Pain is a key feature of arthritis, a disease of the joint and a leading cause of disability in both young and old. Despite recent advances in treating joint inflammation, and the widespread use of pain medications by arthritis patients, adequate pain control is an ongoing and challenging health...

Regulation of Brain-Derived Neurotrophic Factor in Microglia

2012/13-2017/18 • $234,000 • PI
One of the most significant advances in neuroscience research is the realization that neurons are not the only cell type involved in signalling in the central nervous system (CNS). My research focuses on the fundamental biology of how signals are modulated by an understudied class of cells known...

ICS INMHA Brain Star Prize

2014/15 • $750 • PI
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Patents