Recent Research Projects

Longitudinal recording of neuronal function using two photon fluorescence microscopy in adult rats co-expressing genetically encoded calcium indicators and channelrhodopsin-2

2014/15-2018/19 • $210,000 • PI
Summary of Proposal The hundred billion neurons that make up the brain are organized in a highly complex and interconnected network. Supporting the high energetic needs of these neurons is an intricate, hierarchical network of vessels. Superimposed on this anatomical complexity, is great...

Simultaneous optical imaging of oxygenation and blood flow for chronic monitoring of stroke and seizure activity

2012/13-2013/14 • $270,000 • PI,CO
Patients surviving ischemic stroke often express delayed epileptic syndromes. Late poststroke seizures occur after a latency period lasting from several months to years after the insult. These seizures might result from ischemia-induced neuronal death and associated morphological and...

In vivo imaging of neurovascular coupling

2010/11-2013/14 • $91,000 • PI
Functional magnetic resonance imaging has greatly enhanced our understanding of how human brain processes information. In particular, while it is well established that brain activity is associated with local changes in brain blood flow that MRI can detect, the mechanism that links brain activity...