Lawrence Smith

Key Research Areas
Associated Researchers
Associated Organizations

Recent Research Projects

Nuclear-cytoplasmic interactions in mammalian embryos

2015/16-2019/20 • $140,000 • PI
Reproductive success is the single most important measurement of progress of animal breeding programs. However, reproductive success in high-performing domestic animals is significantly compromised by elevated embryonic mortality during gestation and postnatal morbidity. This is particularly...

Biparental haploid cells to generate genomically designed offspring

2019/20 • $136,000 • PI
Dans la sélection naturelle, la capacité de survie des descendants (« fitness ») repose sur le brassage chromosomique pendant la méiose qui permet la production de gamètes haploïdes qui sont génétiquement différents. Cependant, cette variabilité génétique induite par la méiose peut être un...

Use of haploid embryonic cells to generate offspring with predetermined genomes

2016/17-2017/18 • $298,000 • PI
In natural selection, differential fitness relies on the chromosomal shuffling during meiosis that enables the production of haploid gametes that are genetically different. However, meiotic-induced genetic variability can be an economic burden to the animal breeding industry since offspring...

Canada Research Chair in Animal Cloning and Stem Cells

2010/11-2015/16 • $1,100,000 • PI
No summary

NSERC CREATE Training Program in Reproductive Biology

2010/11-2014/15 • $1,500,000 • PI,CO
The overall objective of the program is to create a new, novel, superior and sustainable research training and mentoring environment to form the next generation of reproductive and developmental biologists. This will be achieved by providing multi-institutional, transdisciplinary training from...

Nuclear-cytoplasmic interactions in mammalian embryos

2010/11-2014/15 • $175,000 • PI
The long-term objective of my research program is to investigate the biological mechanisms that orchestrate the genetic and epigenetic programs supporting early development in mammals. Cattle embryos reconstructed by nuclear transfer, i.e. animal cloning, are used to analyze the molecular and...

NSERC EmbryoGENE Strategic Network

2010/11-2013/14 • $3,452,850 • PI,CO
No summary