Hanadi Sleiman

Key Research Areas
Associated Researchers
Associated Organizations

Recent Research Projects

DNA Nanoscience

2012/13-2019/20 • $1,400,000 • PI
A central challenge in nanoscience is the organization of functional components into deliberately designed patterns, to achieve specific function. Because of its molecular recognition specificity, DNA presents a unique opportunity to address this problem. Our group has used DNA to synthesize 2D-...

Supramolecular DNA Structures: From Design to Function

2018/19-2019/20 • $276,000 • PI
*Our research during the last 6 years has led to several discoveries in the fields of supramolecular chemistry and DNA nanotechnology. These include:*(a) DNA cages that encapsulate therapeutics and release them selectively, only when they encounter a molecule that is present in cancer cells, and...

Programmed Molecules for Therapeutics, Sensing and Diagnostics (PROMOTE)

2019/20 • $150,000 • PI,CO
aptamers and switches,biometerials,diagnostics,dna and rna,dna nanotechnology,drug delivery,imaging,nucleic acids,oligonucleotide therapeutics,tissue regeneration

Real-time insights into molecular recognition and biological mechanisms

2019/20 • $149,920 • PI,CO
We seek funding to acquire a surface plasmon resonance (SPR) instrument to study complex binding properties of biomolecular interactions central to our research, including biosensors, nanomaterials, and enzymes that can be used to synthesize antibiotics. The requested equipment will enable new...

DNA Nanocages for the Targeted Cellular Delivery of Chemotherapeutics

2018/19-2019/20 • $140,000 • Scholarship/Fellowship,Other
Chemotherapy is one of the most widely-used and effective methods for treating cancer. Yet its implementation has extreme drawbacks; the drugs used in this protocol are potent, destroying diseased and healthy tissue with equal voracity. This results in the patient suffering a string of adverse...

DNA Nanoscience

2019/20 • $100,000 • PI
A central challenge in nanoscience is the organization of functional components into deliberately designed structures, to achieve specific function. Because of its molecular recognition specificity, DNA presents a unique opportunity to address this problem. This proposal develops this...

Gel modulaire à base d'ADN et de petites molécules pour la guérison dans les cornées artificielles

2019/20 • $50,000 • Scholarship/Fellowship,Other
Chaque annee, entre 2 000 et 3 000 Canadiens attendent une transplantation de la cornee, selon le Journal de l'Association Medicale Canadienne. Dans certaines provinces, la periode d'attente peut durer plus de trois ans ; une periode tres longue pour des patients desirant reprendre une vie...

Three-Dimensional DNA Nanostructures for Biological and Materials Applications

2013/14-2017/18 • $495,000 • PI
Our research group focuses on using the biological molecule DNA to achieve programmable organization on the nanometer scale. In the past five years, we have shown simple and efficient methods to construct a range of 3D-DNA cages and nanotubes, with full control of size and shape. These...

NSERC CREATE Training Program in Bionanomachines

2011/12-2016/17 • $1,650,000 • PI,CO
No summary

Development of DNA-Based Nanoparticles (DNP) for the Targeted Delivery of Therapeutics to Cancer Cells

2016/17 • $25,000 • PI
Chemotherapy drugs have made life-saving advances in cancer treatment, yet patients are still at risk for a hostof negative side-effects. Although these therapies are designed to kill cancer cells, they often end up poisoninghealthy cells, leading to side-effects and drug resistance partially...

DNA Cages as a Platform for Efficient and Selective Delivery of Therapeutics into Tumor Cells

2013/14-2015/16 • $400,000 • PI
General drug cytotoxicity and drug resistance are major hurdles in traditional cancer therapies, stemming from the nonspecific delivery of cancer therapeutics to normal and cancerous cells simultaneously. We aim to develop a new method for targeted cancer therapy using non-toxic DNA cages and...

CIHR-FRSQ Drug Development Training Program (DDTP)

2010/11-2014/15 • $1,630,833 • PI,CO
Progress in biomedical research is driving an unprecedented pace of discovery in the understanding of the molecular mechanisms of disease. However, despite this progress, there is an enormous gap between the discovery of tools that improve our knowledge of disease processes and the numbers of...

DNA cages as a platform for efficient and selective delivery of therapeutics into tumor cells

2013/14-2014/15 • $200,000 • PI,CO
General drug cytotoxicity and drug resistance are major hurdles in traditional cancer therapies, stemming from thenonspecificdelivery of cancer therapeutics to normal and cancerous cells simultaneously. We aim to develop a new method fortargeted cancer therapy using non-toxic DNA cages and...

Visualizing and Directing Dynamic DNA Nanostructure Assembly With Single-Molecule Resolution

2014/15 • $150,000 • PI,CO
The use of DNA in nanotechnology has become increasingly widespread with far-reaching advantages: these natural nanoscale building blocks are self-assembling, are able to organize species such as drugs, nanoparticles, and other biomolecules, and can store and read information to target specific...

Self-assembly of DNA and biologically enabled polymers

2010/11-2012/13 • $165,000 • PI
Our research group focuses on the development of DNA-mediated methods to pattern materials with high precision on the nanometer scale. Towards this goal, we have examined the use of synthetic molecules to direct DNA self-assembly. This approach has resulted in a unique range of previously...

DNA and Protein Imaging System

2012/13 • $49,747 • PI
This is a request for an imaging system that allows the detection, quantification, and purification of DNA and protein samples, and is essential for producing quality publication results and reducing the exposure of students to toxic substances. A major research focus in our research is the use...

Supramolecular Complexes as G-Quadruplex Binders: Towards Effective Telomerase Inhibition

2010/11-2011/12 • $155,510 • PI,CO
The proposed research is focused on targeting a higher-order DNA structure, the guanine quadruplex, and using this strategy to develop selective cancer therapeutics. In contrast to the regular A-T or G-C base-pairing, this association mode of DNA brings together four guanines, and folds a DNA...

Scanning probe microscope to study molecular, biomolecular and polymer self-assembly

2010/11 • $150,000 • PI,CO
This is a request to acquire a Scanning Probe Microscope (SPM) capable of atomic force microscopy and scanning tunneling microscopy imaging at solid-liquid interface. This instrument is capable of sub-nanometer resolution imaging of a variety of molecular and biomolecular structures adsorbed on...

Integrated spectroscopy system

2010/11 • $106,805 • PI,CO
Photoluminescence and Raman spectroscopy are widely used to study the electronic structure, chemical, physical and optical properties of matter. Recently, there has been much interest in minute structures that span length scales from that of few numbers of atoms to more macroscopic dimensions on...

Microfluidic detection system for profiling multiple cancer biomarkers in serum with ultrahigh sensitivity and specificity

2010/11 • $92,400 • PI,CO
In recent years, Canada has invested over a hundred million dollars on proteomics research, and one significant outcome has been the discovery of a number of candidate cancer biomarkers. It has also become clear that early diagnosis of cancer will rely on the detection of not one, but a panel of...

Microfluidic detection system for profiling multiple cancer biomerkers with ultrhigh sensivity

2010/11 • $92,400 • PI,CO
In recent years, Canada has invested over a hundred million dollars on proteomics research, and one significant outcome has been the discovery of a number of candidate cancer biomarkers. It has also become clear that early diagnosis of cancer will rely on the detection of not one, but a panel of...

Self-assembly of DNA and biologically enabled polymers

2010/11 • $40,000 • PI
Our research group focuses on the development of DNA-mediated methods to pattern materials with high precision on the nanometer scale. Towards this goal, we have examined the use of synthetic molecules to direct DNA self-assembly. This approach has resulted in a unique range of previously...

Patents

POLYNUCLEOTIDE-POLY(DIOL) CONJUGATES, PROCESS OF PREPARATION AND USES THEREOF

The present disclosure provides a conjugate of formula (I) (see formula I) wherein each wherein each X, Nt, R, n, m and j are as defined herein. There is also provided a process for preparing a substantially monodisperse conjugate, a composition comprising said conjugate, and the use of a conjugate as defined herein in therapy.
Related applications: CA20152882268

REAGENTS BASED ON A TERTIARY AMINE BACKBONE TO INTRODUCE CHEMICAL FUNCTIONALITY IN NUCLEIC ACIDS AND SEQUENCE-CONTROLLED POLYMERS

It is provided an achiral, non-nucleosidic backbone for phosphoramidites that can be inserted with high yields in nucleic acid strands and sequence-controlled oligo(phosphodiester)s through solid phase synthesis (SPS) using a DNA synthesizer. From this backbone, platforms with useful chemical handles were synthesized, further functionalized, transformed into phosphoramidites and attached to nucleic acid strands and sequence-controlled oligo(phosphodiester)s. The backbone is based on a...
Related applications: WO2019CA51091