Recent Research Projects

Elucidating mechanisms of host-pathogen interactions in chickens

2019/20 • $69,000 • PI
The present program investigates host-pathogen interactions, particularly immune responses to Marek's disease virus (MDV), an oncogenic herpesvirus that causes Marek's disease (MD), in chickens. ******Immunity against MD is dependent on interactions between innate and acquired immune mechanisms....

Is it possible to control avian influenza virus transmission?

2019/20 • $39,900 • PI,CO
Avian Influenza (AI) has emerged as an economically important disease of poultry. Avian influenza viruses (AIV) can be transmitted via various routes, including oral-fecal and airborne routes, however, the relative impact of different routes in AIV outbreaks is unknown. AIV spread is currently...

Immunology of Marek's disease virus infection in chickens

2011/12-2017/18 • $280,000 • PI
Animal infectious diseases are of great importance to human and animal health. Moreover, these diseases impose significant economic losses to the food animal industry. Marek's disease (MD) is a disease of chickens caused by a virus, Marek's disease virus or MDV, and marked by formation of...

The effect of in ovo delivery of nutrients and feed additives on the development of the immune system

2017/18 • $30,000 • PI
The research proposed here focuses on in ovo supplementation of chick embryos with vitamins and probiotic bacteria. Newly hatched chicks are subject to various forms of stress that make them more susceptible to pathogens. Chicks can be made healthier by early interventions, such as by pre-hatch...

Maintaining Ultracentrifugation Capacity for Biological Research at the Ontario Veterinary College

2016/17 • $148,224 • PI,CO
Funds are requested from NSERC to purchase a state-of the-art ultracentrifuge and rotors to maintain core ultracentrifugation capacity within the department of Pathobiology and the Ontario Veterinary College. Equipment requested includes a Beckman BioSafe Optima XPN-90 ultracentrifuge, three...

Control of Campylobacter jejuni in chickens by vaccination

2013/14-2015/16 • $85,000 • PI
Campylobacter jejuni is a major food-borne pathogen. In 2004, there were 9,000 reported cases of human camplylobacteriosis in Canada, compared to 5,000 cases of salmonellosis during the same year. According to some estimates, the annual cost of human campylobacteriosis in the US is over 8...

Development of probiotic formulations with immune enhancing activities for chickens

2012/13-2013/14 • $54,000 • PI
Probiotics are defined as live microorganisms, which when administered in adequate amounts confer a health benefit on the host through improvements to the intestinal microbial balance (FAO/WHO, 2002). Several species of commensal bacteria, including some Lactobacillus bacteria have probiotic...

Identification of commensal lactobacilli with immunomodulatory activities and inhibitory effects on Salmonella colonization in chickens

2010/11-2011/12 • $67,500 • PI
Lactic acid producing bacteria (LAB) are a group of microbes that can be found in the intestines of mammals and avian species. Several LAB, including lactobacilli have been found to have probiotic activities. Some lactobacilli are normal members of the intestinal community of microbes and confer...

Immunology of Marek's disease virus infection in the chicken

2010/11 • $42,980 • PI
No summary

Towards the development of a vaccine for control of avian influenza virus infection in chickens

2010/11 • $42,450 • PI
Avian influenza virus (AIV) is a disease-causing virus, which is of great importance to human and poultry health. This virus has already caused significant economic damage to the Canadian poultry industry. During the recent epidemic of AIV in the Fraser Valley, BC, over 17 million chickens were...

Towards the development of novel vaccines for control of Marek's disease and shedding of Marek's disease virus from feathers

2010/11 • $18,750 • PI,CO
Maintenance of poultry health has been identified as a major objective by the Canadian poultry industry. Marek's disease (MD) is an infectious disease caused by a virus, which afflicts poultry operations in North America and across the globe. The total losses caused by this disease are estimated...



There is provided a vaccine for controlling Clostridium perfringens in an imals, and particularly necrotic enteritis in poultry. The vaccine may compr ise a C. perfringens antigenic polypeptide or variant thereof, a nucleic aci d encoding the C. perfringens antigenic polypeptide or variant thereof, or a recombinant cell producing the C. perfringens antigenic polypeptide or vari ant thereof.
Related applications: EP20080757167, WO2008CA01031, CA20082685533