Laurel Schafer

Key Research Areas
Associated Researchers
Associated Organizations

Recent Research Projects

CREATE Sustainable Synthesis

2013/14-2018/19 • $1,575,000 • PI,CO
CREATE Sustainable Synthesis is a training program designed to address an acknowledged gap in the academic preparation of undergraduate, MSc, PhD and postdoctoral trainees for careers in industry. CREATE Sustainable Synthesis will train students in the field of Catalysis Research, which requires...

Catalyst Development

2016/17-2018/19 • $300,000 • PI
Dr. Schafer's research interests bridge the areas of organometallic and organic chemistry. She has developed a new class of complexes employing low toxicity metals that are easily modified and rapidly assembled. This new family of catalysts shows remarkable reactivity in selective...

Development of N,O Chelated Complexes for the Catalytic Synthesis of Amines and Nitrogen Containing Materials

2016/17-2018/19 • $273,000 • PI
Amine functionalities are incorporated into a broad range of natural products called alkaloids and are key components of a majority of synthetic and naturally occurring biologically active chemicals and materials, such as pharmaceuticals, agrochemicals and anti-microbial plastics. Methods for...

Process to prepare pendant amine containing polymeric products

2018/19 • $14,625 • PI
PPA (PolyPendant Amines) are amine containing polymers that have a broad range of applications ranging from anti-microbial materials to adhesives that can bind layers of incompatible polymeric materials together. A recent breakthrough in the catalytic addition of amine functionality to olefins...

Gel Permeation Chromatography for Functional Materials Characterization

2017/18 • $149,056 • PI,CO
New polymeric materials are required to make advanced plastics, coatings and composite materials for a broad range of applications ranging from new low energy light sources to new adhesives that will allow for paintable plastics. These next generation polymeric materials require the...

From trees to treatments. Catalytic amination of terpenes and biological screening

2017/18 • $25,000 • PI
BC's forest products are rich in naturally occuring terpenes, a class of molecules that display anti-fungal,anti-bacterial and medicinal bioactivity. These molecules can be further chemically modifed to accesscompounds of commercial value as flavours and fragrances as well as medicines,...

High Resolution EI Mass Spectrometer

2016/17 • $150,000 • PI,CO
This proposal is to obtain a high resolution EI mass spectrometer for the analysis of non-polar organic compounds and organometallics. Mass spectrometry is a powerful analytical technique that is used to identify unknown compounds, to quantify known compounds, and to elucidate the structure and...

400MHZ BROADBAND INVERSE DETECTION NMR SPECTROMETER

2016/17 • $150,000 • PI,CO
We propose to urgently upgrade the console and the probe of our 400 MHz broadband inverse detection NMR spectrometer (AV400inv) in the Departmental NMR facility at the University of British Columbia. This multiuser facility is accessed by over 20 research groups and more than 250 HQP are trained...

Urgent need for glovebox replacement

2016/17 • $62,910 • PI,CO
We are requesting a glovebox, which allows sample preparation and experiments to be conducted under an inert atmosphere. This glovebox will replace my 40 year old glovebox that failed during the previous year and will be used mainly to support a highly productive collaboration with Prof. Laurel...

Catalytic and materials methods for recyclable H2 storage strategies

2016/17 • $25,000 • PI
Finding energy rich fuels as alternatives to fossil fuels for application in the transportation sector is an on-goingchallenge. Hydrogen has the highest energy per mass ratio due to its low molecular weight. However, hydrogenstorage is a challenge, due to the poor density of gaseous hydrogen...

Canada Research Chair in Catalyst Development

2011/12-2015/16 • $500,000 • PI
No summary

N.O. chelated complexes of metals of low toxicity. Catalyst development for green chemistry

2011/12-2015/16 • $425,000 • PI
Our research interests bridge the areas of organometallic and organic chemistry. The Schafer group has developed a new class of complexes that are easily modified and rapidly assembled and that take advantage of inexpensive and low toxicity early transition metals. These complexes use easily...

Simultaneous Thermal Analysis (STA) equipped with IR detector (STA-IR)

2015/16 • $143,750 • PI,CO
<p>This research tools and instruments application is for Simultaneous Thermal Analyzer equipped with IR detector (STA-IR) equipment to analyze thermal properties of novel materials that are produced in the applicants laboratories. STA is consist of a TGA and a DSC (thermogravimetric analyzer...

Developing environmentally friendly industrial solvents

2015/16 • $10,000 • PI
Solvents are required reaction media for most chemical manufacturing processes, cleaning agents for most manufactured materials and key components of paints and coatings. Such solvents, including TEXANOL and NMP, are used as coalescing agents and are classified as Volatile Organic Compounds...

Accessing enhanced mechanical properties and processability with branched and cross-linked biodegradable polymers

2012/13-2014/15 • $297,600 • PI,CO
Biodegradable polymers with controlled structure and properties have been of intense interest in the past few years and have been used in applications and products ranging from packaging and agricultural materials to microelectronics. However, existing biodegradable polymer products suffer from...

UBC Chemistry X-ray Diffractometer Upgrade

2014/15 • $150,000 • PI,CO
This application requests funds to upgrade a single-crystal X-ray diffractometer purchased in 2003. The addition of a new molybdenum (Mo) source and repairs to the CCD detector by the manufacturer will accomplish the following: (i) expand the types of crystals that can be examined by this...

Upgrade to UBC-Chemistry Departmental NMR Facility

2013/14 • $150,000 • PI,CO
The UBC-Chemistry Nuclear Magnetic Resonance (NMR) Facility is the only facility on campus that is open to chemistry faculty and students for regular NMR analysis. This facility is critical to the success and training of ca. 250 chemistry trainees at the undergraduate, graduate and postdoctoral...

Investigating environmentally friendly industrial solvents

2013/14 • $24,500 • PI
Solvents are required reaction media for most chemical manufacturing processes, cleaning agents for mostmanufactured materials and key components of paints and coatings. Such solvents, including Methyl EthylKetone (MEK) and Xylene, are commonly used and are sources of Volatile Organic Compounds...

Preparation, characterization and investigation of novel organometallic precursors for nanoparticle synthesis

2012/13 • $25,000 • PI
Novel amidate and azido substituted organometallic complexes will be prepared as soluble precursors for nanoparticle synthesis. In this collaborative project the Schafer group will prepare new complexes for testing by Blue-O-Technology in nanoparticle synthesis. New precursors that can result in...

Development of silica supported hydroamination catalysts

2012/13 • $24,500 • PI
Recent developments in the Schafer group have established early transition metals, metals of low toxicity, as desirable catalyst components for a carbon-nitrogen bond formation called the hydroamination reaction. The products of the hydroamination are critical building blocks for the synthesis...

Green pharmaceutical manufacturing processes: new functional phosphorus-materials as catalyst-supports and metal-scavengers

2010/11-2011/12 • $300,000 • PI,CO
Modern methods for the production of pharmaceuticals involve transition metals in at least one step of the production process. On one hand, the use of metals to catalyze the transformation of one drug precursor to another is attractive because catalysts tend to be highly efficient, selective...

Chiral amidate complexes for the diastereoselective and enantioselective synthesis of chiral amines and N-Heterocycles

2010/11-2011/12 • $200,000 • PI
Catalytic methods afford energy efficient routes for the synthesis of complex molecules. Amines are critical building blocks for the assembly of a broad range of target compounds including alkaloid natural products, pharmaceuticals and agrochemicals. Often the required amine building blocks are...

Equipment for the Characterization of Novel Macromolecules

2011/12 • $120,000 • PI,CO
This research tools and instruments application is for Gel Permeation Chromatographic (GPC) equipment to analyze novel polymers that are produced in the applicants laboratories. GPC is the most important method used in both industry and academic labs to evaluate the size (or molecular weight) of...

Controlled-microstructure biopolymers: from synthesis to processing and final disintegration through composting

2010/11-2011/12 • $110,000 • PI,CO
The main objective of this proposal is to develop novel, sustainable, environmentally-friendly, polymer based nanocomposites by combining controlled-microstructure biodegradable polymers with chemically treated (kraft) pulp fibers, and fluff pulp fibers (precursor to regenerated cellulose fibers...

Intramolecular hydroaminoalkylation for the efficient synthesis of agrochemicals

2011/12 • $24,500 • PI
Catalytic methods afford energy efficient routes for the synthesis of complex molecules. Recent developments in the Schafer group have established early transition metals, metals of low toxicity, as metals with desirable catalytic reactivity in ac new C-C bond forming reaction, the...

Application of new catalytic technologies in the synthesis of substituted piperazines. New approaches for the synthesis of calcium channel blockers for pain treatment.

2010/11 • $50,000 • PI
Catalytic methods afford energy efficient routes for the synthesis of complex molecules. Recent developments from a pharmaceutical company in Vancouver, British Columbia, Neuromed, have shown that a family of nitrogen containing cyclic compounds, piperazines, can be used for a novel approach...

Early transition metal and lanthanide amidate complexes: modular, easily accessed complexes for catalysis

2010/11 • $49,000 • PI
Early transition metals, such as titanium and zirconium, and lanthanide metals have been used successfully for metal-mediated organic synthesis. As catalysts, these metals are able to promote reactions that normally cannot occur. Catalysis is very important for industrial applications, as it...

Patents

GROUP 5 METAL COMPLEXES USEFUL FOR AMINE FUNCTIONALIZATION AND SYNTHETIC PROCESS FOR MANUFACTURE THEREOF

The present invention provides Group 5 metal complexes useful for amine functionalization and synthetic process for manufacture thereof. Provided in this application are halo group 5 metal-amidate complexes having the structure of Formula I: I wherein: M is a group 5 metal, such as Ta, Nb or V; X is a halo substituent, such as CI, F, I or Br; n = 1 or 2,; s = 1 or 2; R1 and R2 are each independently H; a C1 - C25 substituted or unsubstituted, linear, branched or cyclic alkyl; or substituted...
Related applications: WO2011CA50609

GROUP 5 METAL COMPLEXES USEFUL FOR AMINE FUNCTIONALIZATION AND SYNTHETIC PROCESS FOR MANUFACTURE THEREOF

The present invention provides Group 5 metal complexes useful for amine functionalization and synthetic process for manufacture thereof. Provided in this application are halo group 5 metal-amidate complexes having the structure of Formula I: (see formula I) wherein: M is a group 5 metal, such as Ta, Nb or V; X is a halo substituent, such as Cl, F, I or Br, n = 1 or 2,; 8 = 1 or 2; R1 and R2 are each independently H; a C1-C25 substituted or unsubstituted, linear, branched or cyclic alkyl; or...
Related applications: CA20102715907

GROUP 5 METAL COMPLEXES FOR CATALYTIC AMINE FUNCTIONALIZATION

This application pertains to group 5 metal complexes having the structure of Formula I; and their potential utility in catalyzing α-alkylation of secondary amine-containing moieties.
Related applications: WO2018CA50619

GROUP 5 METAL COMPLEXES FOR PRODUCING AMINE-FUNTIONALIZED POLYOLEFINS

This application pertains to group 5 metal complexes having the structure of Formula I: and their potential utility in catalyzing amination of polyolefins having alkene groups.amine-
Related applications: WO2019CA50704, WO2019CA50046