Recent Research Projects

BioZone: An Open Bioscience and Bioengineering Research and Training Environment

2019/20 • $150,000 • PI,CO
biomanufacturing,bioproducts,computational biology,intellectual property,machine learning,microbial biochemistry,open science,public policy,synthetic biology,technoeconnomics assessment

Mining the Legionella core "effectome" for molecular modulators of conserved eukaryotic cell signaling

2018/19-2019/20 • $56,000 • PI
A range of pathogenic and symbiotic gram-negative bacteria, varying from root nodule causing Rhizobium to important animal and human pathogens such as Salmonella and Shigella rely on the collective function of specific set of proteins called effector for colonization of their eukaryotic hosts....

Exploitation of host ubiquitination pathways by pathogenic E. coli

2015/16-2018/19 • $521,343 • PI,CO
Pathogenic E. coli strains cause life-threatening diseases manifesting by recent outbreaks in Canada and worldwide. The ability of these pathogenic bacteria to establish infection in humans and animals depends on combined function of defined set of specific pathogenic factors called "effectors"...

Engineering a broadly cross-protective vaccine that confers sterilizing immunity against Haemophilus influenzae.

2016/17-2018/19 • $447,807 • PI,CO
Haemophilus influenzae is responsible for a substantial proportion of respiratory infections in humans, including ear infections, sinus infections and pneumonia, as well as invasive infections such as meningitis. This bacterium lives in the human upper respiratory tract, not in other animals or...

Engineering of Transferase Enzymes for DNA Synthesis**

2018/19 • $25,000 • PI
DNA sequencing technology has dropped the price of reading DNA over 10,000 times in 10 years. The bottleneck of synthetic biology is now writing (i.e. synthesizing) DNA. Startups in three major economies (US, France, UK) are working on next-generation enzymatic DNA synthesis technology to...

Mining the Legionella core “effectome” for molecular modulators of conserved eukaryotic cell signaling

2017/18 • $28,000 • PI
A range of pathogenic and symbiotic gram-negative bacteria, varying from root nodule causing Rhizobium to important animal and human pathogens such as Salmonella and Shigella rely on the collective function of specific set of proteins called effector for colonization of their eukaryotic hosts....

Operations and Maintenance Support for the BioZone MS Facility

2016/17 • $150,000 • PI,CO
The BioZone mass spectrometry facility (BMSF) is associated with the Department of Chemical Engineering and Applied Chemistry at the University of Toronto and is part of the BioZone Centre for Bioengineering. The BMSF provides services and training to internal and external researchers and...

Overcoming Antibiotic Resistance Through the Inhibition of Aminoglycoside Phosphotransferases (APH).

2013/14-2015/16 • $338,199 • PI
Multidrug resistant microbes have become one of the top global health challenges and place a massive burden on the Canadian health care system. One approach to overcome this problem involves inhibiting the enzymes responsible for conferring resistance to the antibiotic. We have recently...

Patents