John Rubinstein

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Recent Research Projects

Cryo-EM of dynamic protein complexes in protein quality control

2017/18-2019/20 • $213,000 • PI
BACKGROUND: Proteins, which are long chains of chemical building blocks (amino acids) that can fold up to take on precise 3-D structures, are responsible for most of what happens in a living cell. Improperly folded or unwanted proteins must be unfolded, an activity performed by proteins known as...

High-resolution single particle electron cryomicroscopy of membrane protein complexes

2012/13-2016/17 • $240,000 • PI
BACKGROUND: Cell membranes differentiate a cell from its external environment. Proteins that reside within cell membranes, known as membrane proteins, serve as the gateway to cells. These proteins transport chemicals across membranes and allow cells to communicate with each other and sense their...

Examining Biomolecular Interactions using Microscale Thermophoresis

2013/14 • $150,000 • PI,CO
As part of a team of 10 structural biologists at the University of Toronto (spanning several departments and faculties), we use biophysical tools such as Atomic Force Microscopy, NMR spectroscopy, X- ray crystallography and electron cryomicroscopy to analyze the biomolecular interactions between...