Claude Robert

Key Research Areas
Associated Researchers
Associated Organizations

Recent Research Projects

Fragile X Mental Retardation 1 gene: a master switch of ovarian communication and oocyte quality.

2017/18-2019/20 • $180,000 • PI
We have recently observed a previously undescribed mechanism in bovine cumulus oocyte complexes where RNA granules transit in the cellular projections from the somatic cells surrounding the gamete . We have shown that these cargos carry mRNAs that can be transferred to the oocyte . This is...

Amélioration des caractères de santé et fertilité chez la vache laitière par une approche génomique alternative

2016/17-2017/18 • $36,122 • PI
La sélection génétique a permis d'accroitre la production laitière considérablement. Seulement depuis 2005, la moyenne de la race Holstein a progressé de 5% soit l'équivalent d'environ 500 kg de lait par année par vache. Malgré la plus grande productivité, les producteurs s'inquiètent des...

Perfect follicles for perfect oocytes (PFPO)

2014/15-2016/17 • $222,000 • PI,CO
Canada's position as a leader in dairy genetics has been gained through excellent selection, good genetics and the development of assisted reproductive technologies, which involved innovative donor management practices and laboratory breakthroughs. Through these innovations, Canadian producers...

Studying the emerging contributions of long non-coding RNAs as drivers of early embryogenesis.

2012/13-2016/17 • $170,000 • PI
The first week of mammalian life involves a succession of key events that include the formation of a developmentally competent oocyte, fertilization, embryonic genome activation and initiation of cell lineage differentiation. This developmental time frame is also of financial significance since...

Epigenetic and transcriptomic analysis of embryos from oocytes or sperm from peri-pubertal bovine

2013/14-2015/16 • $197,800 • PI,CO
The selection pressure in dairy cow reproduction is resulting in the use of younger animals for reproductive purposes both in the male and the female. One of the limiting parameter is the normal physiology of the brain at puberty which controls the maturation of gametes in both sexes. Although...

Mesure de la méthylation de l'ADN par pyroséquençage

2015/16 • $143,009 • PI,CO
Grâce à des percées majeures au niveau technologique, l'efficacité du séquençage d'ADN s'est décuplé au cours de la dernière décennie ce qui en a fait décroître les coûts. Tous les secteurs de recherche...

Génotypage des protéines de lait chez la vache Canadienne

2014/15 • $25,000 • PI
Au Canada, il se produit environ 248 000 tonnes de fromage spécialisé annuellement (Centre canadiend'information laitière). Selon les mêmes ressources statistiques, chaque Canadien consomme près de 1 kg defromage par mois. Malgré l'importance de l'industrie laitière au Canada, la balance...

NSERC EmbryoGENE Strategic Network

2010/11-2013/14 • $3,452,850 • PI,CO
No summary

Infertility biomarkers: the link between genomic and genetic

2010/11-2012/13 • $95,625 • PI,CO
No summary

Do epigenomic factors influence twin bulls performances?

2012/13 • $28,000 • PI
With the development of tools for genomic evaluation, it is now possible to estimate breeding values at birth. To increase the rate of genetic improvement, there is a recent trend to use young animals as soon as possible and, in order to increase the rate of dissemination of their high merit...

Emergence of long non-coding RNAs as an epigenetic mark influenced by environmental conditions impacting early development

2011/12 • $99,887 • PI,CO
It is well accepted that our genes control how we look and even who we are. It is also well known that our lifestyle impacts on gene expression on many levels. Epigenomics refers to a set of molecular interactions that influences gene expression without altering the DNA sequence itself. One of...

Providing genomic EBVs for pre-transfer bovine embryos

2010/11-2011/12 • $96,176 • PI
No summary

The use of genomic-genetic tools to improve dairy cow reproduction

2011/12 • $13,930 • PI,CO
Industry-wide selection for cows with dairy character (grouping of body traits found to correspond with milk production) has had a negative impact on the fertility of dairy cows. Animal's reproductive ability is an important component of an efficient dariy herd management. Unless a cow can...

Canadian Bovine Mastitis Research Network

2010/11 • $464,721 • PI,CO
No summary

Patents

MAMMALIAN OOCYTE DEVELOPMENT COMPETENCY GRANULOSA MARKERS AND USES THEREOF

The present invention relates to the competence of oocytes for uterine im plantation and development into living individuals The invention more partic ularly relates to markers that are detected and measured in granulosa cells collected along with the oocytes during oocyte aspiration as it is done in a ssisted reproduction techniques Markers include cytochrome P450 aromatase (C YPl 9Al), cell division cycle 42 (CDC42), 3-.beta.-hydroxysteroid dehydrogen ase 1 (3.beta.HSDl), serpm peptidase...
Related applications: WO2007CA01633, CA20072666819, EP20070815827

OVARIAN MARKERS OF OOCYTE COMPETENCY AND USES THEREOF

The present invention relates to the competence of oocytes to fertilization, uterine implantation and development into a living being. The invention describes ovarian markers whose expression is predicative of oocyte competency that are detected and/or measured in follicular fluid, cumulus cells and/or follicular cells of a mammal. Also described are methods for evaluating competence of mammalian oocytes, methods for selecting a mammalian oocyte for assisted reproduction (AR), and screening...
Related applications: WO2010CA01813, EP20100829421