Recent Research Projects

A unique model to assess the oral transfer of dietary microRNAs

2019/20 • $82,046 • PI,CO
MicroRNAs modulate ~60% of our genes and are important to our health, as deregulation of microRNA levels has been associated with a panoply of major human diseases, including cancer. Intriguingly, all the plant and animal species composing our diet contain "dietary" microRNAs that we ingest on a...

A novel class of small non-coding RNAs

2019/20 • $42,000 • PI
Central to the flow of genetic information (DNA makes RNA makes protein), small RNA species that do not code for proteins, such as microRNAs, have evolved as key regulators of gene expression; this is required to preserve well-balanced protein expression/levels, to maintain normal cellular...

Role, function and regulation of human Dicer

2013/14-2017/18 • $215,000 • PI
The molecular mechanisms regulating the expression of mammalian genomes is more complex than previously thought, with the recent discovery of gene regulatory processes based on small non-coding RNA species, such as microRNAs. Expressed in almost all living eukaryotes, microRNAs act in concert to...

Dietary microRNAs

2014/15-2015/16 • $237,254 • PI,CO
MicroRNAs are small endogenous non-coding RNA species that play a crucial role in finely tuning gene expression, which is required to maintain homeostasis and to remain healthy. Expressed in the vast majority of eukaryotes, such as humans, animals and plants, microRNAs may regulate ~60% of the...

In Vivo Imaging System

2013/14 • $150,000 • PI,CO
IN VIVO IMAGING SYSTEM The ultimate validation of fundamental discoveries that we make using in vitro assays or cellular models is to demonstrate their biological relevance in live animals. We thus need to monitor the response of animals to genetic, molecular and physiological manipulations from...

Dietary microRNAs

2013/14 • $100,000 • PI,CO
MicroRNAs are small endogenous non-coding RNA species that play a crucial role in finely tuning gene expression, which is required to maintain homeostasis and to remain healthy. Expressed in the vast majority of eukaryotes, such as humans, animals and plants, microRNAs may regulate ~60% of the...

Role, function and regulation of human Dicer

2012/13 • $28,000 • PI
The molecular mechanisms regulating the expression of mammalian genomes are more complex than previously thought, with the recent discovery of gene regulatory processes based on small non-coding RNA species, such as microRNAs. Expressed in almost all living eukaryotes, microRNAs act in concert...

Alteration of the microRNA pathway during the aging process

2010/11 • $50,000 • PI
Containing ~20,000 to 25,000 genes, the human genome may express more than ~200,000 messenger RNAs (mRNAs) that can be translated into more than ~2,000,000 different proteins, the main constituents of cells. A finely tuned regulatory control of gene expression is thus required in order to...

Elucidation of the Dicer protein interaction network

2010/11 • $25,000 • PI
The human genome contains ~35,000 genes, from which more than ~200,000 messenger RNAs (mRNAs) can be derived. These mRNAs have the potential of encoding more than ~2,000,000 different proteins, the main constituents of cells. Recent studies have unveiled the existence and biological significance...

Patents