Meng-Chuan Lai

Contact via Centre for Addiction and Mental Health

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Recent Research Projects

Brain Function and Connectomics Following Sex Hormone Treatment in Adolescents Experiencing Gender Dysphoria

2018/19-2019/20 • $390,150 • PI,CO
Adolescence is a time of rapid brain maturation that is partly influenced by sex hormones. We are currently using magnetic resonance imaging to assess the influence of sex hormones on brain structure. This project will take us one step further and use state-of-the-art functional magnetic...

Early relapse detection in youth depression: development of secondary prevention methods by multiplex digital phenotyping

2019/20 • $158,737 • PI,CO
Background and Importance: Major Depressive Disorder (MDD) in youth (MDD-Y) is a common and recurrent mood disorder, affecting 7-18% of young people. MDD-Y has severe impacts on psychosocial development, family and school functioning, long-term health outcomes, and increases risk of death by...

Early prediction of developmental outcomes: a prospective study of infants with high-impact genetic risk variants

2019/20 • $137,700 • PI,CO
Identifying the genetic cause of Autism Spectrum Disorder (ASD) sufficiently early in life can be beneficial in several ways; e.g., early interventions may improve outcomes and allow a timely start of appropriate educational supports. The problem is that a genetic cause is virtually always...

Understanding Diagnostic Pathways of Autism Spectrum Disorder: Towards Improving the Timely Identification and Care of Girls and Women

2018/19-2019/20 • $73,333 • Scholarship/Fellowship,Other
Autism Spectrum Disorder (ASD) is reported to be four to five times more common in boys than in girls. The methods and criteria for diagnosing ASD, however, are largely based on studies with boys, which recent research suggests may overlook girls and women who present differently. Indeed, girls...

Effects of Puberty Blockers on Brain Function in Adolescents Experiencing Gender Dysphoria: A Functional Magnetic Resonance Imaging Study

2019/20 • $15,000 • Scholarship/Fellowship,Other
Transgender adolescents strongly experience themselves as another gender. A popular explanation of brain development in transgender individuals is that it is shifted in the direction of the experienced gender rather than the birth gender. Transgender adolescents are often recommended puberty...