Joseph W. Bondy-Denomy

Contact via University of Toronto

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Recent Research Projects

The role of Pseudomonas aeruginosa bacteriophages in Cystic Fibrosis: modulation of disease progression and development of phage therapy

2010/11-2012/13 • $105,000 • Scholarship/Fellowship,Other
Pseudomonas aeruginosa is a bacterium found in soil and water and is also able to cause human infections. Common P. aeruginosa infections target the lung, urinary tract, eyes, ears and burn wounds. Individuals with Cystic Fibrosis (CF) are highly susceptible to P. aeruginosa infection and once...

The Diversity and Impact of Bacteriophages in Pseudomonas aeruginosa

2010/11 • $6,000 • Scholarship/Fellowship,Other
No summary



The present disclosure provides compositions and methods for introducing or enhancing Aca activity in prokaryotic cells. The provided compositions and methods can be used to inhibit Acr activity in prokaryotic cells, thereby enhancing endogenous or exogenous CRISPR-Cas activity. Cells, polynucleotides, plasmids, phage, and other elements for practicing the present methods are also provided.
Related applications: WO2020US35403, EP20200812564