Gregg Adams

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Recent Research Projects

Ovulation-inducing factor in semen: Implications for mammalian fertility

2018/19-2019/20 • $129,840 • PI
Two of the most intriguing mysteries in reproductive biology are the persistence among species of an elaborate accessory gland system in males and the phenomenon of copulation-induced ovulation in females. Our discoveries about an ovulation-inducing factor (OIF) in seminal plasma provide at...

Ovulation-inducing factor in semen: Implications for mammalian fertility

2013/14-2017/18 • $200,000 • PI
We have discovered a component in the semen of the male that elicits an ovulatory response in the female, and we have found it in every species examined thus far. The existence of an ovulation-inducing factor (OIF) in seminal plasma has broad implications and immediately evokes questions about...

NSERC EmbryoGENE Strategic Network

2010/11-2013/14 • $3,452,850 • PI,CO
No summary

Ovulation-inducing factor: implications for mammalian fertility

2010/11-2012/13 • $135,000 • PI
Ovulation is a fundamental event in the reproductive process of all mammalian species. Ovulation failure or untimely ovulation has a profound impact on fertility. Exciting data from the applicant's laboratory has now cast new light on factors responsible for eliciting the ovulatory cascade....

Patents

USE OF AROMATASE INHIBITORS FOR SYNCHRONIZING OVULATION, INDUCING SUPEROVULATION OR DOUBLE OVULATION AND IMPROVING TWINNING AND FERTILITY IN A MAMMAL

Described herein is the use of an aromatase inhibitor (i.e. lezotrole) for synchronizing ovulation in a herd or a single mammal. Also described is the use of said aromatase inhibitor at the beginning of a follicular wave emergence for inducing superovulation; from day 1 to day 7 following follicular wave emergence for inducing double ovulation, before dominant follicle selection to improve twinning and in early estrus or mid-diestrus following insemination for improving fertility in a mammal.
Related applications: CA20112837494, WO2011CA00578, EP20110782809

PROTEIN-FREE SEMEN CRYOPRESERVATION

This disclosure provides a preserving composition comprising a cholesterol: carrier complex, optionally a cholesterol: cyclodextrin complex (CC complex) and/or a cell permeable antioxidant peptide and a biological buffer and optionally a cryprotectant, wherein the preserving composition is optionally substantially free of animal phospholipid, animal protein and/or animal lipoprotein. The disclosure also provides methods for the use of the preserving composition in cryopreservation of semen...
Related applications: WO2018CA51545