David A. Hart

Contact via University of Calgary

Key Research Areas
Associated Researchers
Associated Organizations

Recent Research Projects

De-implementing low value care: a research program of the Choosing Wisely Canada Implementation Research Network

2018/19-2019/20 • $750,000 • PI,CO,Other
Up to 30% of tests and treatments given to patients are not needed. This can lead to significant inconvenience and harms for these patients without any benefit. It also wastes money for patients and the health system. Choosing Wisely Canada (CWC) is engaging patients and health professionals to...

Fibre-optic sensors in knee joint cartilage surfaces for accurate detection of normal and abnormal, in vivo stresses on the cartilage

2017/18 • $100,000 • PI,CO
Post-traumatic osteoarthritis (PTOA) is a degenerative disease of articular joints initiated by a traumatic injury, followed by progressive, irreversible, damage to the articular cartilage (the tissue that lines the parts of bones that meet at a joint and allows pain free articulation). OA...

Controlling inflammation to prevent the development of osteoarthritis following reconstruction of the anterior cruciate ligament and drill hole surgery

2014/15-2016/17 • $133,333 • Scholarship/Fellowship,Other
Osteoarthritis (OA) is a joint disease that involves articular cartilage breakdown, loss of joint function with pain and severe disability. With millions of people affected globally, OA of the knee joint is a huge health care burden, and it is becoming more traumatizing due to joint injuries in...

Canadian Research Leaders in Musculoskeletal Health: A Self-Assembled National Consortium

2016/17 • $9,999 • PI,CO
The planning activities will start a conversation among representative musculoskeletal (MSK) group leaders to solidify relationships, foster new partnerships, increase awareness of strengths, identify synergies, and recognize collaborative opportunities. A focus will be set on enhancing...

Centre for Hip Health and Mobility: A Team Approach to Mobility in Vulnerable Seniors

2010/11-2014/15 • $1,115,325 • PI,CO,Other
Our Emerging Team will focus on the Vancouver Integrated Study of Aging & Mobility (VISA-M) -- a prospective observational study of a cohort of 850 women aged 65 -75 years recruited in the Lower Mainland around Vancouver, Canada. Long-term aims: The primary purpose of VISA-M is to describe risk...

Pathogenesis of tendinopathy: Clinical and laboratory studies

2010/11-2014/15 • $654,293 • PI,CO
Repetitive-use tendon injury (typically called "tendinitis") is a major clinical burden in many Canadian industries. Unfortunately, how and why this condition develops is poorly understood. Improved treatment will require increased knowledge of the causes of this common, costly condition. In...

Ligament Transplantation

2010/11-2012/13 • $407,253 • PI,CO
The anterior cruciate ligament (ACL) is one of the primary stabilizers of the knee joint that heals poorly when torn. The clinical rationale for this study is that annually 100,000 North Americans undergo tendon autograft surgeries that restabilize the joint but do not prevent the development of...

A New Emerging Team: The Canadian Scleroderma Research Group

2010/11-2011/12 • $358,346 • PI,CO
Scleroderma is an uncommon but serious disease that primarily causes tight skin but also affects many internal organs. To do research on this disease, we have established the Canadian Scleroderma Research Group, which will gather blood, tissue and information from patients across Canada having...

Neuroinflammatory Mechanisms in Joint Contracture Development

2010/11-2011/12 • $213,603 • PI,CO
Following injuries to joints, many people suffer functional deficits due to loss of motion (joint contracture) as a complication of the injury. Our research focuses on changes in the structures surrounding the joint that limit joint motion. One such structure, the joint capsule, is similar to a...

Feasibility of a randomized controlled trial of ketotifen for lateral epicondylalgia

2011/12 • $14,322 • PI,CO
Lateral epicondylitis (LE) is common tendinopathy seen in workers engaged in repetitive manual or gripping activities. While its prevalence in the general population is approximately 3%, in certain industries the prevalence is much higher (e.g. 15% in fish-processing workers). It is more common...

In vivo mechanobiology of joints and articular cartilage in models of joint degeneration and osteoarthritis

2010/11 • $81,529 • PI,CO
Osteoarthritis is the most common form of arthritis and affects about 10% of the total population and about 50% of all people 60 years and older in Canada. Although the detailed mechanisms leading to osteoarthritis are not known, it is well accepted that mechanical joint loading plays a major...

An experimental animal model of muscle weakness and joint degeneration

2010/11 • $40,692 • PI,CO
There is an abundance of clinical and anecdotal evidence that muscle weakness may be a risk factor for joint degeneration and osteoarthritis. However, the relationship between muscle weakness and joint degeneration has not been studied systematically in controlled experimental trials. The aim of...

Characterization of Mesenchymal Stem Cells in Knee Synovial Fluid in a Porcine Model: Precursor frequency for chondrogenic, osteogenic, and adipogenic lineages.

2010/11 • $17,500 • Scholarship/Fellowship,Other
Articular cartilage damage frequently results from trauma induced in a joint, high impact activities and very commonly from osteoarthritis. Due to a poor intrinsic repair capacity, articular cartilage has a limited ability to regenerate. Current methods used in clinical practice are inadequate,...