Caroline Lamarche

Key Research Areas
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Recent Research Projects

Tailoring antigen-specific regulatory T cells for use in transplantation

2017/18-2018/19 • $97,500 • Scholarship/Fellowship,Other
Transplantation is the best and sometimes only treatment for end-stage organ failure. In the last ten years, the lives of more than 20,000 Canadians have been improved, extended, or saved by donated organs. Immunosuppressive drugs make transplantation possible, but since these drugs cannot...

Patents

ANTI-HLA-A2 ANTIBODIES AND METHODS OF USING THE SAME

Provided are humanized anti-HLA-A2 antibodies. In certain aspects, the humanized anti-HLA-A2 antibodies are capable of constituting an antigen binding domain of a chimeric antigen receptor (CAR), where the CAR is capable of being expressed in a human cell such that the CAR specifically binds to HLA-A2. Also provided are CARs that include the humanized anti-HLA-A2 antibodies. Modified cells including the antibodies and CARs, as well as methods of using such modified cells are also provided.
Related applications: WO2018CA51167, EP20180858795

NOVEL ANTI-HLA-A2 ANTIBODIES AND USES THEREOF

The present invention relates to a novel anti-HLA-A2 antibody, and to a chimeric antigen receptor comprising said HLA-A2 antibody. The present invention further relates to an immune cell expressing said chimeric receptor antigen, and to therapeutic uses thereof, in particular for treating or preventing graft rejection or GVHD.
Related applications: WO2018CA51174, EP20180859115