Nicholas Dawson

Key Research Areas
Associated Researchers
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Recent Research Projects

Manipulating immune regulation to improve the success of hematopoietic stem cell transplantation.

2016/17-2017/18 • $105,000 • Scholarship/Fellowship,Other
For many blood cancer patients, hematopoietic stem cell transplantation (HSCT, also known as bone marrow transplantation) is the only option for a cure. HSCT works by replacing the patient's blood stem cells with new blood stem cells from a donor. The donated blood stem cells give rise to a new...

Patents

ANTI-HLA-A2 ANTIBODIES AND METHODS OF USING THE SAME

Provided are humanized anti-HLA-A2 antibodies. In certain aspects, the humanized anti-HLA-A2 antibodies are capable of constituting an antigen binding domain of a chimeric antigen receptor (CAR), where the CAR is capable of being expressed in a human cell such that the CAR specifically binds to HLA-A2. Also provided are CARs that include the humanized anti-HLA-A2 antibodies. Modified cells including the antibodies and CARs, as well as methods of using such modified cells are also provided.
Related applications: WO2018CA51167, EP20180858795