John R. Matyas


Contact via University of Calgary


Key Research Areas
Associated Researchers
Associated Organizations

Recent Research Projects

Central and peripheral determinants of acute and persistent joint pain

2016/17-2019/20 • $393,716 • PI,CO
Pain with motion, pain at rest, pain at night, sharp pain, dull pain-pain is highly variable among and within those afflicted with arthritis. Much is now known about joint tissue changes in arthritis, but only a little is known about how pain that begins in the joint makes its way to the spinal...

Role of neuroinflammation in the development of chronic joint pain

2016/17-2019/20 • $378,429 • PI,CO
Chronic joint pain is a common cause of disability that is difficult to treat effectively and is poorly understood. The symptoms of chronic pain reported by arthritis patients closely resemble those reported by patients with nerve injuries. This suggests that arthritis pain might be caused, at...

Regulation of microglial pannexin-1 channels in arthritis pain

2019/20 • $175,185 • PI,CO
Pain is a key feature of arthritis, a disease of the joint and a leading cause of disability in both young and old. Despite recent advances in treating joint inflammation, and the widespread use of pain medications by arthritis patients, adequate pain control is an ongoing and challenging health...

Regulation of microglial pannexin-1 channels in arthritis pain

2018/19 • $100,000 • PI,CO
Pain is a key feature of arthritis, a disease of the joint and a leading cause of disability in both young and old. Despite recent advances in treating joint inflammation, and the widespread use of pain medications by arthritis patients, adequate pain control is an ongoing and challenging health...

Muscle rehabilitation of cerebral palsy patients recieving botulinum toxin type-A (Botox) treatments

2011/12-2013/14 • $281,362 • PI,CO
Background: Cerebral Palsy (CP) is an umbrella term designating a group of non-progressive neurological disorders. One common treatment in CP is chemical denervation of spastic muscles using botulinum toxin type-A (BTXA). However, in pilot work we demonstrated that BTXA injections cause atrophy,...

Stem cells as promoters of skeletal repair

2010/11-2011/12 • $554,750 • PI,CO
Embryonic stem cells offer a potential endless supply of cells for the therapeutic restoration of degenerative disorders including skeleton. Based on current orthopedic practice, which is focused on the use of materials to repair bone and cartilage, the skeleton appears to be a ripe target for...

In vivo mechanobiology of joints and articular cartilage in models of joint degeneration and osteoarthritis

2010/11 • $81,529 • PI,CO
Osteoarthritis is the most common form of arthritis and affects about 10% of the total population and about 50% of all people 60 years and older in Canada. Although the detailed mechanisms leading to osteoarthritis are not known, it is well accepted that mechanical joint loading plays a major...

Patents