Recent Research Projects

Central and peripheral determinants of acute and persistent joint pain

2016/17-2019/20 • $393,716 • PI,CO
Pain with motion, pain at rest, pain at night, sharp pain, dull pain-pain is highly variable among and within those afflicted with arthritis. Much is now known about joint tissue changes in arthritis, but only a little is known about how pain that begins in the joint makes its way to the spinal...

Role of neuroinflammation in the development of chronic joint pain

2016/17-2019/20 • $378,429 • PI,CO
Chronic joint pain is a common cause of disability that is difficult to treat effectively and is poorly understood. The symptoms of chronic pain reported by arthritis patients closely resemble those reported by patients with nerve injuries. This suggests that arthritis pain might be caused, at...

Derivation of a clinical prediction guide in the diagnosis of facet joint mediated pain in the cervical spine.

2010/11-2012/13 • $105,000 • Scholarship/Fellowship,Other
Neck pain can be a disabling condition and its physical, psychological, societal, and occupational implications can be overwhelming. The disc, facet joint, ligaments, and nerves can all be a source of pain in those with chronic neck problems. Research has shown that the facet joints can be a...

Neuroinflammatory Mechanisms in Joint Contracture Development

2010/11-2011/12 • $213,603 • PI,CO
Following injuries to joints, many people suffer functional deficits due to loss of motion (joint contracture) as a complication of the injury. Our research focuses on changes in the structures surrounding the joint that limit joint motion. One such structure, the joint capsule, is similar to a...

Regenerative therapy for the intervertebral disc

2010/11-2011/12 • $95,348 • PI,CO
Intervertebral disc-related low back pain is one of the most significant orthopaedic disorders in industrialized society, costing the U.S. economy some $50-100 billion annually, with comparable per capita costs to the Canadian economy. Despite the economic burden of intervertebral disc (IVD)...