Khosrow Adeli

Key Research Areas
Associated Researchers
Associated Organizations

Recent Research Projects

Fundamental and Translational Studies of Diabetic Dyslipidemia in Insulin Resistant States

2016/17-2019/20 • $1,472,198 • PI,Other
I have been a senior scientist in both basic scientific and clinical research for over 25 years. Due to numerous achievements and publications, my laboratory is now recognized as a leader in both fields with major national and global impact. The main focus of my research program has been to...

The risk for premature atherosclerosis in survivors of childhood cancer: A study in the Preventing Cardiac Sequelae in Pediatric Cancer Survivors (PCS2) cohort

2018/19-2019/20 • $369,750 • PI,CO
Most children newly diagnosed with cancer will survive their illness. Unfortunately, many of these survivors will develop long-term complications from their cancer treatment that can lead significant illness and even early death. Heart disease is the most common non-cancer cause of early death...

Metabolomics for prediction of cisplatin mediated acute kidney injury: a Canadian multi-centre adult and pediatric study

2019/20 • $324,224 • PI,CO
Cisplatin is a widely used drug to treat cancer in both children and adults. Although effective in treating cancer, cisplatin causes kidney damage in approximately one third of patients that take the drug. The objective of this project is to determine why one third (33%) of patients have kidney...

Precision Fluid Biomarkers of Traumatic Brain Injury

2018/19 • $100,000 • PI,CO
Traumatic Brain Injury (TBI) is one of the most challenging brain disorders to study. TBI can happen to anyone at any time, at any level of severity. TBI spans a wide range of severity from mild (including concussions) to life-threatening injuries, and there is much uncertainty about how to...

Determining normative levels and biological variation of intestinal lipid and endocrine biomarkers of the metabolic syndrome and assessing their prognostic value in the metabolic syndrome and its related complications

2016/17-2017/18 • $105,000 • Scholarship/Fellowship,Other
To correctly interpret laboratory test results, physicians require up-to-date reference intervals (RIs), the 'normal' range of values in a healthy population. Due to the complexity of determining RIs and the ever-changing laboratory technologies, pediatric RIs are lacking, compromising the...

Mining the gap: Establishment of pregnancy-specific laboratory reference intervals using provincial laboratory data

2016/17 • $68,230 • PI,CO
Monitoring health during pregnancy requires accurate interpretation of laboratory test results. Test results for an individual patient are compared to a reference interval - the range of values expected in a representative healthy population - to determine if the result is abnormal. Drastic...

CALIPER: A Canada-Wide Initiative to Close the Critical Gaps in Pediatric Reference Intervals

2011/12-2015/16 • $739,727 • PI,CO
CALIPER (Canadian Laboratory Initiative in Pediatric Reference Intervals) is a multi-centre study among several children's hospitals across Canada to establish a current and accurate database of pediatric reference intervals (normal values) that represent Canada's children and youth,...

PROMOTE: Preschoolers at Risk - Obesity trajectories & cardioMetabolic factors: Towards Early identification

2011/12-2015/16 • $655,641 • PI,CO
The metabolic syndrome is a group of factors including obesity, and abnormalities in blood pressure, insulin, and cholesterol that has been shown to be associated with type 2 diabetes and heart disease in adults. There is emerging evidence that rapid growth in early childhood increases the risk...

CIHR Training Program in Protein Folding and Interaction Dynamics: Principles and Diseases

2010/11-2014/15 • $1,637,500 • PI,CO
Understanding protein folding and protein interactions is one of the central concerns in biology. While the structure of the protein native state is dictated by the amino acid sequence of the protein, the mechanisms of spontaneous and chaperone-assisted folding remain elusive. Furthermore, the...

Mechanisms of intestinal lipoprotein overproduction in insulin resistant states

2010/11-2014/15 • $813,990 • PI
Insulin resistance is a very common disorder observed in subjects with conditions such as obesity and type 2 diabetes and is now considered to be an important risk factor in the development of heart disease (and higher risk of heart attacks). The incidence of insulin resistant states has been...

Molecular Mechanisms of Hepatic and Intestinal Insulin Resistance: Role of Mesenteric Fat and Ceramides

2011/12-2014/15 • $225,000 • PI,CO
Insulin resistance is a very common disorder observed in subjects with conditions such as obesity and type 2 diabetes and is now considered to be an important risk factor in the development of atherosclerosis and coronary heart disease. The incidence of insulin resistant states has been...

Understanding the beneficial role of glucagon-like peptide-1 (GLP-1) for normalizing intestinal lipoprotein metabolism during insulin resistance

2013/14-2014/15 • $105,000 • Scholarship/Fellowship,Other
Type 2 diabetes has been labelled a world-wide epidemic, with 285 million individuals currently affected; a number that is expected to reach 439 million by the year 2030. Though this condition is known for causing high blood sugar levels, abnormalities in blood lipoproteins are what ultimately...

Characterization of the molecular links between apolipoprotein B mRNA translation and hepatic insulin resistance

2010/11-2011/12 • $86,250 • Scholarship/Fellowship,Other
In individuals with diabetes, up to 80% of deaths are attributed to heart disease resulting from elevated cholesterol and triglyceride (TG) in the blood. Apolipoprotein B (apoB) is a protein that is made in the liver and released into the blood bound to cholesterol and TG. High level of apoB,...

CALIPER: A Canadian Initiative to Close the Critical Gaps in Pediatric Reference Intervals

2011/12 • $66,667 • PI,CO
CALIPER (Canadian Laboratory Initiative in Pediatric Reference Intervals) is a multi-centre study among several children's hospitals across Canada to establish a current and accurate database of pediatric reference intervals (normal values) that represent Canada's children and youth,...

CALIPER: Closing the Gaps in Pediatric Reference Intervals

2010/11 • $100,000 • PI,CO
CALIPER (Canadian Laboratory Initiative in Pediatric Reference Intervals) is a multi-centre study among several children's hospitals across Canada to establish a current and accurate database of pediatric reference intervals (normal values) that represent Canada's children and youth,...

Establishment of A New Database of Pediatric Laboratory Reference Intervals for Biomarkers of Pediatric Disease

2010/11 • $66,196 • PI,CO
This is an important healthcare initiative to establish a current and accurate database of paediatric reference intervals (normal values) that represent Canadian children and youth. Paediatric reference intervals refer to a range of blood test results obtained from a group of healthy children...

Mechanisms of Glucagon-Like Peptide-2 (GLP-2)-Stimulated Intestinal Secretion of Apolipoprotein B48 (apoB48)-Containing Lipoproteins

2010/11 • $35,000 • Scholarship/Fellowship,Other
Diabetes has been described as an epidemic due to the immense number of Canadians that are becoming afflicted by the disease every year. Cardiovascular disease is a common but deadly complication of diabetes. There is evidence that the dietary fat absorbed in our gastrointestinal tract can...

Patents