Key Research Areas
- NERVOUS SYSTEM
- AXON GUIDANCE
- SPINAL CORD DISEASE
- Signal transduction
- NERVOUS SYSTEM DEVELOPMENT
- Molecular biology
- INJURY, REGENERATION
- SPINAL CORD
- SONIC HEDGEHOG
- BRAIN TUMORS (INCL. RETINAL TUMORS)
- MODEL ORGANISM
- MULTIPLE DISEASE RELEVANCE
- NEURAL DEVELOPMENT
- Other medical research
- PAR COMPLEX
- PEUTZ-JEGHER SYNDROME
- BOC RECEPTOR
- BRAIN TUMOUR
- Cell biology
- COMMISSURAL NEURONS
- CONGENITAL ANOMALIES
- EXOME SEQUENCING
- GROWTH CONE
- HEDGEHOG SIGNALING
- HUMAN GENETICS
- LATERALIZATION OF MOTOR CONTROL
- MIRROR MOVEMENTS
No partner organizations found.
Recent Research Projects
2015/16-2019/20 • $3,062,946 • PI
The morphogen Shh promotes proliferation and cell fate specification in the developing nervous system. In addition, we have shown that Shh is also an axon guidance molecule. This discovery led us to identify novel key players and novel molecular mechanisms in Shh signaling. We have expanded this...
2014/15-2019/20 • $1,100,000 • PI
Our research focuses on an important molecule for embryonic development, known as Shh. Firstly, we study the role of Shh receptors in development of a brain malformation called holoprosencephaly. Secondly, we aim to understand how Shh helps to correctly connect neurons during nervous system...
2019/20 • $100,000 • PI,CO
Lateralization of motor control refers to the ability to perform asymmetric and unilateral movements, and is essential for activities such as coordinated hand movements and walking. The right and left sides of the nervous system communicate through crossing fibers. Defective lateralized motor...
Investigation of the molecular mechanisms leading to polarized Sonic Hedgehog signal transduction in axonal growth cones
2015/16-2016/17 • $127,500 • Scholarship/Fellowship,Other
Our brain and spinal cord is a very complex assembly of millions of cells that are linked to each other by specific connections. The way each neuron sends its principal projection, called the axon, to contact precisely other neurons is crucial. This network is the foundation of our cognitive,...
2010/11-2015/16 • $795,154 • PI
The brain is composed of billions of interconnected neurons. To correctly form neuronal circuits, the developing axons (a long extension of a neuron) require attractive and repulsive molecules to lead them to their appropriate targets. One such molecule is called Sonic Hedgehog (Shh). Dr....
2011/12-2015/16 • $517,637 • PI
The Sonic hedgehog (Shh) protein is important for diverse biological processes during embryonic development. For example, Shh functions to pattern the limbs and the nervous system. Despite its importance, the molecular mechanism underlying Shh signaling during embryonic development remains...
2012/13-2015/16 • $392,675 • PI
Medulloblastoma is a very aggressive childhood cerebellum cancer and the most common brain tumor in children. One of the important causes of medulloblastoma is aberrant activation of the Sonic hedgehog (Shh) signaling pathway. Our lab recently identified a novel receptor for the secreted protein...
2011/12-2013/14 • $150,000 • Scholarship/Fellowship,Other
Cancer is a disease that starts when our cells divide inappropriately, often because they have lost an essential "tumour suppressor" gene that normally keeps them from dividing. An example of a tumour suppressor is LKB1, a gene which is lost in patients with Peutz-Jegher syndrome, who are 100...
2010/11 • $14,500 • PI