Pierre-Étienne Jacques

Key Research Areas
Associated Researchers
Associated Organizations

No partner organizations found.

Recent Research Projects

BIOS2: Computational Biodiversity Science and Services

2018/19-2019/20 • $450,000 • PI,CO
No summary

Genetic instability of the haploid male germ cells

2018/19-2019/20 • $417,561 • PI,CO
Genetic diversity is provided by de novo transmittable mutations and it is now known that most new mutations are male- driven. During the formation of spermatozoa, the final steps involves a major change in the way DNA is packaged and we demonstrated that this is accompanied by the formation of...

Engineering of a probiotic bacterium for precise microbiome editing

2019/20 • $162,945 • PI,CO
We propose to develop a safe-to-use, efficient and programmable conjugative probiotic (COP) as a highly innovative tool to precisely edit the microbiome and fight multidrug resistant pathogens. The E. coli Nissle 1917 probiotic strain, which has previously been shown to be clinically safe, is...

Epithelial-specific role of SOCS1 in prevention of intestinal inflammation

2019/20 • $157,590 • PI,CO
Ulcerative colitis (UC) is a common inflammatory bowel disease (IBD) typified by recurring episodes of inflammation and tissue injury in the mucosal layers of the colon. The SOCS1 protein is an inhibitor of cytokine signaling affecting intestinal inflammation in a cell-specific manner, but its...

Genetic instability of the haploid male germ cells

2018/19-2019/20 • $105,596 • PI,CO
Genetic diversity is provided by de novo transmittable mutations and it is now known that most new mutations are male- driven. During the formation of spermatozoa, the final steps involves a major change in the way DNA is packaged and we demonstrated that this is accompanied by the formation of...

Engineering of a probiotic bacterium for precise microbiome editing

2018/19 • $100,000 • PI,CO
We propose to develop a safe-to-use, efficient and programmable conjugative probiotic (COP) as a highly innovative tool to precisely edit the microbiome and fight multidrug resistant pathogens. The E. coli Nissle 1917 probiotic strain, which has previously been shown to be clinically safe, is...

Genetic instability of the haploid male germ cells

2014/15-2017/18 • $408,854 • PI,CO
Genetic diversity is provided by de novo transmittable mutations and it is now known that most new mutations are male- driven. During the formation of spermatozoa, the final steps involves a major change in the way DNA is packaged and we demonstrated that this is accompanied by the formation of...

Patents