Jason J. McDougall


Contact via Dalhousie University


Key Research Areas
Associated Researchers
Associated Organizations

Recent Research Projects

Restitution Enhancement in Arthritis and Chronic Heart disease

2014/15-2019/20 • $2,357,188 • PI,CO
Many diseases share common pathways through which they cause damage. This is particularly true of diseases which result from inappropriate or uncontrolled immune system activity and tissue damage in a process known as inflammation. Rheumatoid arthritis is an inflammatory disease that affects...

Contribution of Proteases and Protease Activated Receptors to Joint Neuropathy and Arthritis Pain

2017/18-2019/20 • $456,705 • PI
At present, there are 4.6 million Canadians living with the pain of arthritis for which there are inadequate drug treatments. Current medications provide only limited pain relief and most drugs have significant negative side-effects. Thus, there is an urgent need to discover novel, more...

Regulation of microglial pannexin-1 channels in arthritis pain

2019/20 • $175,185 • PI,CO
Pain is a key feature of arthritis, a disease of the joint and a leading cause of disability in both young and old. Despite recent advances in treating joint inflammation, and the widespread use of pain medications by arthritis patients, adequate pain control is an ongoing and challenging health...

The Role of Proteinases in the Progression of Osteoarthritis Neuropathy and its associated Pain.

2018/19-2019/20 • $105,000 • Scholarship/Fellowship,Other
Arthritis is ranked as the number one cause of disability in Canadian women, and number three in men. Osteoarthritis (OA) is the most common type of arthritis, affecting 1 in 10 Canadians. Remarkably, 60% of OA patients cite inadequate pain relief with current treatments. This is possibly...

Regulation of microglial pannexin-1 channels in arthritis pain

2018/19 • $100,000 • PI,CO
Pain is a key feature of arthritis, a disease of the joint and a leading cause of disability in both young and old. Despite recent advances in treating joint inflammation, and the widespread use of pain medications by arthritis patients, adequate pain control is an ongoing and challenging health...

The relationship between proteases, protease activated receptors and cytokines in mediating osteoarthritis pain

2011/12-2015/16 • $601,280 • PI
Osteoarthritis (OA) is the most common form of arthritis affecting 1 in 10 Canadians. The number one concern for OA sufferers is the alleviation of joint pain; however, current analgesics are either ineffective or produce toxic side-effects. Thus, there is a pressing need to discover novel drug...

Validating the existence of high risk gait patterns that are predictive for structural and symptom progression and their implication for physical activity: A study of the interrelationship among physical activity, biomechanical and neuromuscular characteristics related to long term and short term knee osteoarthritis progression outcomes.

2015/16 • $100,000 • PI,CO
Maintaining a physically active lifestyle requires healthy leg muscles, bones, and joints. Osteoarthritis (OA), a disease that damages the joints of the body, results in significant pain that decrease people's physical abilities, making them more prone to chronic health problems. Specifically...

Host-parasite interactions alter joint inflammation in mouse model systems

2010/11-2013/14 • $350,004 • PI,CO
The incidence of arthritic disease is increasing globally. Joint inflammation is severely debilitating and impacts millions of Canadians, disrupting the quality of life of the patients and their families, and has a major socio-economic implication (eg healthcare costs & lost productivity). A...

We Are Family - The importance of parents, peers and partners in pain relief

2013/14 • $3,000 • PI,CO
As of 2011 15% of Nova Scotians aged 12 and over report they usually have pain or discomfort that is moderate to severe and/or prevents usual daily activities. Chronic pain affects every aspect of a person's life including their ability to work, their emotional, mental and physical health as...

The role of proteinase activated receptor 4 in mediating joint pain in the monosodium iodoacetate model of osteoarthritis

2011/12 • $4,950 • Scholarship/Fellowship,Other
Of all types of arthritis, osteoarthritis (OA) is the most prevalent. OA affects mostly the weight-bearing joints of the body, such as ones in the hips, knees and spine. This chronic musculoskeletal condition characterized by joint degeneration and unremitting joint pain is amongst the leading...

Protease activated receptor-4 involvement in inflammatory joint disease and pain

2010/11 • $130,908 • PI
At one time or another, most of us have discovered that joints possess sensory nerves. An ankle or knee sprain is immediately painful alerting the individual to tissue injury and the possible need for medical attention. This short-term pain has a protective effect on our joints by minimizing...

Patents