Recent Research Projects

Anti-CD11d immunotherapy for CNS trauma

2016/17-2019/20 • $602,044 • PI,CO
Traumatic brain injury (TBI) and spinal cord injury (SCI) are catastrophic, giving rise to lifelong disabilities. While the primary causes of SCI and TBI may differ, they both trigger robust acute inflammatory reactions that negatively impact recovery and may lead to the development of long-term...

Evaluating inhibitors of CSPG synthesis in models of spinal cord injury

2019/20 • $164,476 • PI
Other than general medical support, there are currently no therapies to treat spinal cord injury. Chondroitinase has been shown by many laboratories to produce significant benefits to recovery from spinal cord injury in a variety of animal species and in a variety of injuries. Chondroitinase...

Investigating the role of SOX9 in recovery from spinal cord injury

2014/15-2018/19 • $655,672 • PI
There are currently no therapies to treat spinal cord injury. We have focused on designing strategies that enhance the body's normal reparative responses to spinal cord injury. One such natural response to spinal cord injury is to rewire spinal cord circuits to regain lost function. A second...

Treadmill training and SOX9 ablation: a combination therapy to improve locomotor recovery of spinal cord-injured mice

2013/14 • $4,950 • Scholarship/Fellowship,Other
Spinal cord injury (SCI) is a catastrophic event that is a major health care issue, causing lifelong disability. In the USA and Canada, more than 12,000 spinal cord injuries occur annually, and ~275,000 people live with permanent, serious disabilities due to SCI (Cdn. Paraplegic Assoc.). Since...

Targeting SOX9 to alter scar gene expression and promote regeneration after spinal cord injury

2010/11-2012/13 • $469,473 • PI
Spinal cord injury (SCI) is a catastrophic event that is a major health care issue, causing lifelong disability. In the USA and Canada, more than 12,000 spinal cord injuries occur annually, and ~275,000 people live with permanent, serious disabilities due to SCI (Cdn. Paraplegic Assoc.). Since...

Leukocyte integrins as targets for neuroprotective strategies after spinal cord injury

2010/11 • $117,935 • PI,CO
Spinal cord injury (SCI) is a catastrophic event and a major health care issue, causing lifelong disability to its victims. In Canada ~1100 people suffer SCI annually, and ~36,000 live with permanent, serious disabilities due to SCI (Can. Paraplegic Assoc.). SCI happens to young people, usually...

Patents

ANTI-CD11D ANTIBODIES AND USES THEREOF

Antibodies to human CD11d, compositions comprising such CD11d antibodies, and methods of using such CD11d antibodies for the treatment of central nervous system trauma including spinal cord injury and traumatic brain injury, as well as systemic inflammatory response following central nervous system trauma.
Related applications: WO2017CA50240, CA20173015398