Michael D. Hill


Contact via University of Calgary


Key Research Areas
Associated Researchers
Associated Organizations

Recent Research Projects

Advancing Concussion Assessment and Treatment in Children and Youth

2015/16-2020/21 • $3,341,337 • PI,Other
Each year, millions of children sustain concussions/mild traumatic brain injuries (mTBI), and 15-25% suffer persistent symptoms and declines in quality of life. Clinicians caring for these children face three critical, unanswered questions: how to diagnose concussion, how to predict which...

The BedMed Initiative - Making better use of existing therapeutics

2016/17-2020/21 • $1,457,782 • PI,CO,Other
High blood pressure (present in 1 out of every 5 Canadian adults) increases the risk of heart attacks and strokes. Blood pressure lowering pills reduce this risk - but we may not be using these drugs optimally. A study conducted in Spain suggests that using blood pressure pills at BEDTIME,...

TEMPO-2 - A randomized controlled trial of TNK-tPA versus standard of care for minor ischemic stroke with proven occlusion.

2018/19-2020/21 • $1,195,695 • PI,CO
Most minor strokes are due to lack of blood getting to a part of the brain. When this occurs, patients get sudden loss of function in that region of the brain. This might mean inability to move a limb or inability to speak. In the luckiest case, this dysfunction resolves rapidly by itself and we...

Effects of aerobic exercise on cognition and brain health in older adults at increased risk of Alzheimer disease and dementia: probing the biological mechanisms using translational physiology.

2015/16-2020/21 • $1,087,238 • PI,CO,Other
Cerebral blood flow (CBF) is highly regulated by carbon dioxide and oxygen in the arterial blood. This process becomes impaired with cerebrovascular disease processes and by aging. Aging is associated with a progressive decline in CBF, which is a major risk factor for Alzheimer disease (AD) and...

Innovative Clinical Trials Program - Interdisciplinary Chronic Disease Collaboration

2020/21 • $750,000 • PI,CO,Other
Chronic diseases are associated with shorter lifespans, frequent contact with the health care system, and reduced quality of life. New ways of delivering health services are needed to promote health and ensure consistent, high quality care for Canadians living with chronic conditions. It is...

Alteplase Compared to Tenecteplase in patients with Acute Ischemic Stroke: QuICR & OPTIMISE Registry based Pragmatic Randomized Controlled Trial

2019/20-2020/21 • $656,518 • PI,CO
When a clot blocks blood supply to a blood vessel supplying the brain, it causes a stroke. Patients who suffer from stroke can lose important brain functions like speech, motor power and vision can even die from the stroke. Modern acute stroke treatment is based on removing the clot from the...

RESTORE: Robot Enhanced Stroke Therapy Optimizes Rehabilitation

2018/19-2020/21 • $591,323 • PI,CO
Treatment after stroke often involves rehabilitation. Rehabilitation involves learning to move and feel again through intensive practice. It may require tens of thousands of repetitions of a particular movement to relearn it after stroke. Robots can help increase intensity as many therapists...

Imaging Tools for Quick and Appropriate Triage of Stroke Patients

2016/17-2020/21 • $556,666 • PI,CO
Stroke, mainly caused by a blood clot blocking a brain artery, is the leading cause of morbidity in the developed world. Removing the clot quickly saves at-risk brain tissue, improving the patient's chance of a good outcome. A current clinical method for removing blood clots is giving a drug...

Magnetic Resonance Imaging Evaluation of NA1 Neuroprotection on Infarct Growth Following Endovascular Treatment for Acute Ischemic Stroke.

2018/19-2020/21 • $482,874 • PI,CO
Stroke occurs when there is a blockage of a brain artery which stops blood flow causing brain damage and disability. Rapid removal of the blockage with micro instruments, a procedure called endovascular therapy (EVT), has been shown to dramatically improve the functional outcome of patients with...

Stroke Metrics for quAlity, Reporting, and Translation in the implementation of EndoVascular Thrombectomy (SMART-EVT)

2020/21 • $331,252 • PI,CO
Stroke happens when a blood vessel in the brain is blocked. Every 9 minutes, a Canadian has a stroke. Endovascular thrombectomy (EVT) is a procedure to unblock blood vessels in the brain. With this treatment, fewer people die, more people are able to return home and go back to do activities they...

Evaluating oral peri-operative acetylsalicylic acid in patients undergoing endovascular coiling-only of unruptured brain aneurysms. A Phase 3 Multicenter Randomized Placebo-Controlled Trial

2019/20-2020/21 • $312,693 • PI,CO
Brain aneurysms are balloon-like weak spots on the surface of brain arteries. About 900,000 Canadian have brain aneurysms. Aneurysms can burst to cause potentially-fatal bleeding, but the majority cause no symptoms. Thanks to advances in medical imaging, aneurysms can now be identified and...

The Optimal Anticoagulation for Enhanced Risk Patients Post-Catheter Ablation for Atrial Fibrillation (OCEAN) Trial

2020/21 • $127,500 • PI,CO
This trial is comparing medical approaches for stroke prevention in people who have atrial fibrillation (AF) but have undergone a successful procedure called ablation to eliminate or substantially reduce the arrhythmia. AF is normally associated with an increased risk of stroke which in many...

Atlantic Canada Together Enhancing Acute Stroke Treatment (ACTEAST): Improving Access and Efficiency of Treatment

2020/21 • $105,825 • PI,CO
Stroke is a devastating disease, as the leading cause of severe physical disability. Ischemic stroke is the most common form of stroke; and is treatable with medical treatment and a new minimally invasive surgical procedure. These treatments can transform lives, but minutes matter for improving...

Feasibility of Advanced Consent for ParticipaTION in Acute Stroke Trials (ACTION)

2020/21 • $100,000 • PI,CO
Before a patient can be enrolled into a medical research study, he or she must give permission (called consent) to the researchers to do so. But what happens when someone is too sick to give permission, like when they are having a stroke? Currently, researchers usually try to find a family...

Ischemic stroke due to large vessel occlusion: the evolution of treatment, outcomes, and the health system in response to the availability of highly efficacious treatment options.

2019/20-2020/21 • $90,000 • Scholarship/Fellowship,Other
Stroke is one of the leading causes of disability and death in Canada. However, stroke affects men and women differently. Women experience greater disability compared to men after stroke. The reasons for these differences are unknown and are difficult to study in large populations. A new stroke...

CVT in BC: Incidence, Diagnosis, Treatment Strategies and Prognosis of Cerebral Venous Thrombosis in British Columbia, Canada

2019/20-2020/21 • $82,298 • PI,CO
Cerebral venous thrombosis describes blood clots that form in veins that drain blood from the brain. It is most common in younger adults and around pregnancy. It can cause headaches, vision loss, weakness, seizures and coma. Fifteen percent of patients are left dead or disabled and 25% cannot...

Extension of Stroke Care by Added neuroProtection to Endovascular treatment (ESCAPE-NA1)

2016/17-2019/20 • $2,148,245 • PI,CO
Major ischemic stroke is a fatal and disabling condition. Treatment with endovascular thrombectomy, a new treatment proven in the Canadian ESCAPE trial, markedly improves good outcomes. However, 50% of patients still have a poor outcome. To improve outcomes further, we will use a novel medicine...

Canadian Stroke Trials for Optimized Results (CaSTOR)

2014/15-2019/20 • $1,500,000 • PI,CO
Canadian stroke researchers have been past leaders in the field of stroke treatment. We are now proposing to build upon that past reputation and build a strong national network of clinical stroke researchers who will take stroke treatment, stroke prevention and stroke rehabilitation and recovery...

Developing a stroke-specific comorbidity index to predict mortality and disability in a population-based study

2017/18-2019/20 • $192,044 • PI,CO
Stroke occurs when a blood vessel in the brain is blocked. Many patients die after a stroke. Survivors may live with disabilities. They may have difficulty doing simple things like bathing or cooking and may no longer be able to live in their home. Knowing the risk of being disabled is very...

SECRET: Study of rivaroxaban for CeREbral venous Thrombosis

2018/19-2019/20 • $191,250 • PI,CO
Cerebral venous thrombosis is a condition where blood clots form in the draining veins of the brain. It is a rare type of stroke but when it occurs it tends to affect younger women. 75% of patients are female and 80% are under the age of 50. People with CVT can have severe headaches, vision...

The Optimal Anticoagulation for Enhanced Risk Patients Post-Catheter Ablation for Atrial Fibrillation (OCEAN) Trial

2019/20 • $100,000 • PI,CO
This trial is comparing medical approaches for stroke prevention in people who have atrial fibrillation (AF) but have undergone a successful procedure called ablation to eliminate or substantially reduce the arrhythmia. AF is normally associated with an increased risk of stroke which in many...

Canadian Atrial Fibrillation Stroke Prevention Intervention Network (CAF-SPIN)

2013/14-2018/19 • $4,450,000 • PI,CO
Atrial fibrillation is an irregular beating of the heart and is one of the most common causes of stroke in Canada. Fortunately, medical research, has produced several treatments, including blood thinners and blood pressure lowering drugs, which can reduce the risk of stroke by over 75%. However;...

Rehabilitation, Stroke Deficits And Robotic Technology (RESTART)

2014/15-2018/19 • $843,556 • PI,CO
Fifty thousand Canadians each year have a stroke. Afterwards, most of them have problems with movement, sensation, vision or language after the stroke and require rehabilitation. Measurement of these problems and how badly a person has been affected by a stroke is very important. It determines...

The Optimal Anticoagulation for Enhanced Risk Patients Post-Catheter Ablation for Atrial Fibrillation (OCEAN) Trial

2018/19 • $100,000 • PI,CO
This trial is comparing medical approaches for stroke prevention in people who have atrial fibrillation (AF) but have undergone a successful procedure called ablation to eliminate or substantially reduce the arrhythmia. AF is normally associated with an increased risk of stroke which in many...

Robot-Enhanced Stroke Therapy Optimizes REhabilitation (RESTORE)

2017/18 • $100,000 • PI,CO
Treatment after stroke often involves rehabilitation. Rehabilitation involves learning to move and feel again through intensive practice. It may require tens of thousands of repetitions of a particular movement to relearn it after stroke. We use robots to help increase the intensity as many...

TEMPO-2 - A randomized controlled trial of TNK-tPA versus standard of care for minor ischemic stroke with proven occlusion

2017/18 • $100,000 • PI,CO
Most minor strokes are due to lack of blood getting to a part of the brain. When this occurs, patients get sudden loss of function in that region of the brain. This might mean inability to move a limb or inability to speak. In the luckiest case, this dysfunction resolves rapidly by itself and we...

EmPOwER: Engaging Persons with cerebral venous thrombosis for meaningful Outcomes and peER support: A patient engagement initiative of the SECRET (Study of rivaroxaban for CeREbral venous Thrombosis) Trial

2017/18 • $40,000 • PI,CO,Other
Cerebral venous thrombosis (CVT), a deep venous clot in the draining veins around the brain, is a rare kind of stroke. Most patients affected are younger women: 75% are female and 80% are under the age of 50. Though outcomes after CVT have been considered as "excellent" as most people with the...

Engaging Persons with cerebral venous thrombosis for meaningful Outcomes and peER support (EmPOwER)

2017/18 • $10,250 • PI,CO,Other
Cerebral venous thrombosis (CVT), a deep venous clot in the draining veins around the brain, is a rare kind of stroke. Most patients affected are younger women: 75% are female and 80% are under the age of 50. Though outcomes after CVT have been considered as "excellent" as most people with the...

Diagnosis Of Uncertain-origin Benign Transient neurological symptoms. (DOUBT)

2011/12-2016/17 • $548,048 • PI,CO
Stroke and transient ischemic attacks (TIA) are both due to a blockage in an artery in the brain. When it occurs, part of a patient's brain does not work properly giving them symptoms such as an inability to move one side or to speak. In the best case, this resolves quickly and we call this a...

Precise and Rapid assessment of collaterals using multi-phase CTA in the triage of patients with acute ischemic stroke for IV or IA Therapy (PRoVe-IT)

2014/15-2016/17 • $272,271 • PI,CO
Stroke is the 3rd leading cause of death in North America and a leading cause of disability in Canada. Most strokes are caused by a blood clot blocking supply of blood to the brain. Collaterals are small connections between arteries in the brain that maintain blood flow to the brain beyond a...

Identifying Stroke Therapeutics From Preclinical Models: Using Network Meta-Analysis

2016/17 • $100,000 • PI,CO
Background Despite decades of preclinical and clinical research, stroke continues to kill 6 million people every year globally1. By 2006 there were at least 1,026 preclinical (i.e. in vitro and in vivo) experimental treatments for acute stroke with published data, and 114 preclinical therapies...

TEMPO-2 - Multicentre, prospective randomized open label, blinded-endpoint (PROBE) controlled trial of thrombolysis with low dose Tenecteplase (TNK-tPA) versus standard of care in the prevention of disability at 3 months in minor ischemic stroke with proven acute symptomatic occlusion.

2016/17 • $100,000 • PI,CO
Most minor strokes are due to lack of blood getting to a part of the brain. When this occurs, patients get sudden loss of function in that region of the brain. This might mean inability to move a limb or inability to speak. In the luckiest case, this dysfunction resolves rapidly by itself and we...

Poise-2

2011/12-2015/16 • $3,584,223 • PI,CO
Five hundred thousand adults in Canada, and 2 hundred million worldwide, have major surgery every year. Several million of these patients will have a major heart problem (example, a heart attack or death) after their surgery. We recently finished the worlds largest randomized trial testing the...

Identifying New approaches to optimize Thrombus characterization for predicting Early Recanalization and Reperfusion with iv tPA using Serial CT angiography (INTERRSeCT)

2012/13-2015/16 • $261,446 • PI,CO
The treatment of strokes has greatly improved over the last few decades with the development of drugs, which limit the damage produced by stroke. In addition, physicians are able to use imaging technology to see the brain and its vessels in new ways using CT scans. These scans can reveal an...

NeuroVISION Study: Detection And Neurological Impact Of Cerebrovascular Events In Noncardiac Surgery Patients: A Cohort Evaluation Study

2014/15-2015/16 • $217,695 • PI,CO
Two hundred million adults worldwide have major surgery every year. A million of these patients will have an obvious stroke after their surgery. Another 10 million patients may have 'silent' strokes. Although silent strokes are not diagnosed immediately, they are likely to reduce patients'...

CIHR Team in Safety Culture for Spinal Manipulation Therapy:(SAFETY NET: an academic and professional partnership building a culture of safety for Spinal Manipulation Therapy)

2010/11-2014/15 • $1,600,000 • PI,CO
High velocity/low amplitude (HVLA) spinal manipulation, a non-invasive manual procedure applied to specific body tissues with therapeutic intent, is the most common complementary and alternative medicine (CAM) practice in North America. Manipulation is most commonly provided by chiropractors...

The Advancement and Democratization of Medical Research in Canada Through the Development and Validation of Randomized-Registry Trials

2014/15 • $100,000 • PI,CO,Other
The randomized-registry trial (RRT) is an emerging alternative to conventional randomized clinical trial (RCT) that may revolutionize the conduct of clinical research. RRTs combine elements of conventional RCTs and of observational studies by linking together data from dedicated registries and...

Improving Acute Stroke Services by Co-Creating Patient Centred Research

2014/15 • $15,000 • PI,CO,Other
Stroke is a debilitating disease that effects a large proportion of people as either stroke survivors or informal caregivers. Time is brain, and treating patients faster will save lives and reduce disability. This project aims to improve acute stroke services by co-creating patient centred...

"Spot Sign" Selection of Intracerebral Hemorrhage to Guide Hemostatic Therapy (SPOTLIGHT): A Randomized Controlled Trial

2010/11-2013/14 • $1,708,141 • PI,CO
This study tackles the problem of intracerebral hemorrhage, a serious type of stroke caused by bleeding into the brain from a ruptured blood vessel. It accounts for 10-30% of all strokes worldwide, often affecting young people, and is the deadliest, most disabling, and least treatable stroke...

Effects of Regular Exercise on Cerebrovascular Reserve in Older Adults: Role in the Prevention of Age-Related Cognitive Decline

2010/11-2013/14 • $539,140 • PI,CO
Cerebral blood flow (CBF) is highly regulated by carbon dioxide and oxygen in the arterial blood. This process becomes impaired with cerebrovascular disease processes and by aging. Aging is associated with a progressive decline in CBF, which is a major risk factor for stroke. In premenopausal...

Assessment of hypertension occurrence, management and outcomes in Canada

2010/11-2012/13 • $513,062 • PI,CO
Hypertension is one of the most common conditions worldwide affecting more than 1 in 5 adult Canadians. More patients visit physicians and receive prescriptions for the treatment of hypertension than any other medical disorder, with over 4 million prescriptions for antihypertensive medication...

REhabilitation, Stroke deficiTs And Robotic Technology (RESTART)

2010/11-2012/13 • $199,384 • PI,CO
Fifty thousand Canadians each year have a stroke. Most of them have problems with movement, sensation, vision or language after their stroke and require rehabilitation. Measurement of how badly a person has been affected by a stroke is very important. It determines what treatment they need and...

CT And MRI in the Triage of TIA and minor Cerebrovascular events to identify High risk patients. (CATCH)

2010/11-2011/12 • $185,119 • PI,CO
Most strokes are caused by a blockage of an artery in the brain. In some stroke patients the symptoms from this blocked artery are mild or even transient. There are around half a million stroke patients who present with transient or mild stroke symptoms every year in North America. In the more...

Poise-2

2011/12 • $100,000 • PI,CO
Two hundred million adults worldwide, and 500,000 adults in Canada, have major surgery every year. Several million of these patients will have a major heart problem (example: a heart attack or death) after their surgery. We recently finished the world's largest randomized study testing the...

Identifying New approaches to optimize Thrombus characterization for predicting Early Recanalization and Reperfusion with iv tPA using Serial CT angiography (INTERRSeCT)

2011/12 • $100,000 • PI,CO
The treatment of strokes has greatly improved over the last few decades with the development of drugs, which limit the damage produced by stroke. In addition, physicians are able to use imaging technology to see the brain and its vessels in new ways using CT scans. These scans can reveal an...

Diagnosis Of Uncertain-origin Benign Transient neurological symptoms. (DOUBT)

2010/11 • $93,615 • PI,CO
Stroke and transient ischemic attacks (TIA) are both due to a blockage in an artery in the brain. When it occurs, part of a patient's brain does not work properly giving them symptoms such as an inability to move one side or to speak. In the best case, this resolves quickly and we call this a...

Patents