Wolfram G. Tetzlaff

Contact via University of British Columbia

Key Research Areas
Associated Researchers
Associated Organizations

Recent Research Projects

Role of endogenous remyelination after spinal cord injury

2018/19-2020/21 • $736,815 • PI
Myelin is the fatty insolation layer surrounding nerve fibres that enables the fast conduction of electrical impulses. This layer also plays a role in the nutrition and maintenance of the nerve fibres themselves. Loss of myelin occurs in diseases like multiple sclerosis and spinal cord injury....

Role of endogenous Stem/Progenitor cells in spinal cord injury and cellular transplantation

2013/14-2018/19 • $793,029 • PI,CO
Cellular transplantation is deemed a viable approach to repair spinal cord injuries (SCI), however, the optimal cell for transplantation is still debated, and the mechanisms how transplanted cells improve function of the injured spinal cord are not well understood. In our previous work with...

Biomechanical factors in spinal cord injury - relevance to the timing of decompression

2014/15-2017/18 • $423,361 • PI,CO
Spinal cord injuries (SCIs) are caused primarily by high-speed injury to the body where severe forces are exerted on the human neck, which result in various patterns of bony injury to the neck. Further, recent research by our group has shown that these different patterns of bony injury also...

Ketogenic Diet for Spinal Cord Injury - Preclinical Studies

2012/13-2015/16 • $225,000 • PI,CO
About 4 million people worldwide live with paralysis from traumatic spinal cord injury (SCI) and an estimated 200,000 SCI occur every year. Yet there is no cure and treatment is limited to surgery to stabilize the spine, and physical rehabilitation. We found that rats recover better from spinal...

Promoting Neural Regeneration and Functional Recovery after Chronic and Severe Spinal Cord Injury

2013/14-2015/16 • $105,000 • Scholarship/Fellowship,Other
Though spinal cord injury (SCI) affects an estimated 42,000 Canadians, no treatment options aimed at reversing symptoms of this devastating disease exist. This is especially the case for patients suffering from complete injuries, which result in full paralysis and loss of sensory function below...

Stem cells to treat spinal cord injury

2010/11-2013/14 • $1,732,962 • PI,CO
Each year, approximately 1000 Canadians sustain an acute traumatic spinal cord injury and join close to 40,000 paralyzed individuals across our nation who endure one of the most physically and psychologically devastating of injuries. We have recently shown that two novel populations of stem...

Repair mechanisms of human skin-derived precursors differentiated into Schwann cells (SKP-SCs) transplanted into the injured rodent spinal cord.

2012/13-2013/14 • $105,000 • Scholarship/Fellowship,Other
Spinal cord injury (SCI) affects an estimated 42,000 Canadians and represents a substantial financial burden for the Canadian health care system. The motor, sensory and autonomic dysfunctions associated with SCI result primarily from the loss of projecting axons (which carry electrical signals)...

Clinically relevant mechanisms of spinal cord injury

2010/11-2012/13 • $485,822 • PI,CO
Spinal cord injury (SCI) is a major public health problem, devastating for the afflicted individuals and very costly for our health care system. SCI begins with mechanical insult to the cord (i.e. primary injury), followed by a series of biological events that further damage the cord. The...

Development of MRI techniques for animal models of Spinal Cord Injury

2010/11-2011/12 • $221,187 • PI,CO
There are approximately 11,000 new cases of spinal cord injury (SCI) each year in North America. They often result in severe physical impairment and disability that persists for the life of the patient. Apart from the obvious human and social costs, the economic burden on the health care system...

Promoting oligodendrocyte differentiation and remyelination in the central nervous system by attenuating myelin inhibition

2010/11-2011/12 • $37,500 • Scholarship/Fellowship,Other
Within the central nervous system (CNS), myelin produced by oligodendrocytes, is responsible for rapid impulse conduction. The importance of myelin is highlighted by disorders, such as multiple sclerosis (MS) and spinal cord injury (SCI), in which demyelination has been directly linked to...

Dietary restriction and spinal cord injury

2010/11 • $62,835 • PI,CO
We discovered recently that dietary restriction, in the form of every other day fasting (EODF), improved outcomes from incomplete cervical spinal cord injury (SCI) in rats. Thus, the standard clinical practice of providing high/early caloric nutrition during the acute phase of SCI may not be...