Jeffrey A. Biernaskie


Contact via University of Calgary


Key Research Areas
Associated Researchers
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Recent Research Projects

Understanding dermal progenitor cell biology towards improved skin wound healing.

2018/19-2019/20 • $449,820 • PI,CO
More than 14 million severe skin wounds (burns, trauma, ulcers) are treated each year in North America. The consequence is chronic pain, immobility, disfigurement and in many cases infection leading to further medical complication or death, particularly in the elderly. The annual societal cost...

Understanding Schwann cell heterogeneity for improved nerve repair

2018/19-2019/20 • $430,848 • PI,CO
Traumatic injuries to nerve and other disorders affecting nerve (called neuropathies) are common conditions, resulting in severe paralysis, sensory loss and pain in many Canadians. Techniques to repair nerve injuries to date allow some recovery of function, but most patients continue to have...

Role of neuroinflammation in the development of chronic joint pain

2016/17-2019/20 • $378,429 • PI,CO
Chronic joint pain is a common cause of disability that is difficult to treat effectively and is poorly understood. The symptoms of chronic pain reported by arthritis patients closely resemble those reported by patients with nerve injuries. This suggests that arthritis pain might be caused, at...

Role of microglia during remyelination

2019/20 • $159,376 • PI,CO
In the brain and spinal cord, the tissue is either white matter or grey matter. White matter has its colour because it is enriched in fats due to a structure called myelin. Myelin surrounds the brain and spinal cord nerve fibres, called axons. The purpose of myelin is to speed communication, but...

Single-cell RNA-Sequencing of dermal progenitors recruited in regenerative wounds to identify signals promoting skin regeneration.

2019/20 • $50,000 • Scholarship/Fellowship,Other
More than 14 million severe skin wounds (resulting from burns, trauma, ulcers) are treated each year in North America. The result is intractable chronic pain, immobility, disfigurement and in many cases infection leading to further medical complication or death. The annual societal cost of wound...

Role of endogenous Stem/Progenitor cells in spinal cord injury and cellular transplantation

2013/14-2018/19 • $793,029 • PI,CO
Cellular transplantation is deemed a viable approach to repair spinal cord injuries (SCI), however, the optimal cell for transplantation is still debated, and the mechanisms how transplanted cells improve function of the injured spinal cord are not well understood. In our previous work with...

Understanding dermal progenitor biology towards improving skin wound healing.

2018/19 • $100,000 • PI,CO
More than 14 million severe skin wounds (burns, trauma, ulcers) are treated each year in North America. The consequence is chronic pain, immobility, disfigurement and in many cases infection leading to further medical complication or death, particularly in the elderly. The annual cost of wound...

Single-cell transcriptomics of dermal progenitors recruited in regenerative wounds to identify signals promoting skin regeneration.

2018/19 • $5,000 • Scholarship/Fellowship,Other
Adult mammalian wound healing generates a non-functioning mass of fibrotic tissue and leads to permanent loss of skin appendages. The result is disfigurement from scarring, chronic disability, and complications that can be fatal. In adult mice, skin repair following a small wound leads to...

Transcriptional profiling of dermal stem cells recruited in a regenerative wound to identify signals enabling skin regeneration.

2017/18 • $5,000 • Scholarship/Fellowship,Other
In adult mice, the skin repair process following a small skin wound leads to a non-functioning mass of scar tissue which results in permanent disfigurement. In contrast, large wounds elicit a regenerative response which results in the formation of new hair follicles, glands, and fat tissue...

Examining the role of dermal stem cells in wound healing and the influence of niche-derived factors that govern their behavior.

2011/12-2016/17 • $300,000 • PI
In 2005, more than 11 million skin wounds (burns, trauma) were treated in emergency departments in the North America. In addition, at least 3 million adults are reported to have pressure ulcers yearly. The result is chronic pain, immobility, disfigurement and in many cases infection leading to...

Characterizing dermal stem/progenitor contribution during endogenous skin regeneration versus scar formation.

2016/17 • $100,000 • PI
More than 14 million severe skin wounds (burns, trauma, ulcers) are treated each year in North America. The result is intractable chronic pain, immobility, disfigurement and in many cases infection leading to further medical complication or death. The annual cost of wound care in Canada alone is...

Examining the role of dermal stem cells in wound healing and the influence of niche-derived factors that govern their behavior

2010/11-2015/16 • $705,694 • PI
In 2005, 11 million skin wounds (burns, trauma) were treated in emergency departments in the United States. At least 3 million adults in the North America are reported to have pressure ulcers yearly. The result is chronic pain, immobility, disfigurement and in many cases infection leading to...

Understanding the role of dermal stem cells in skin wound healing and tissue regeneration.

2011/12 • $4,950 • Scholarship/Fellowship,Other
In 2005, more than 11 million skin wounds (burns, trauma) were treated in emergency departments in the North America. Moreover, at least 3 million adults in the North America are reported to have pressure ulcers every year. The result is chronic pain, immobility, disfigurement and in many cases...

Patents