Richard B. Thompson


Contact via University of Alberta


Key Research Areas
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Recent Research Projects

Quantitative Magnetic Resonance Imaging of the Human Brain: Technical Innovation and Application to Neurological Disorders

2016/17-2020/21 • $944,422 • PI,Other
Magnetic resonance imaging (MRI) provides unparalleled insight into human disease. Through continued technical innovation, we will further its utility by advancing image acquisition, quantitative analysis, and physics knowledge. Our novel brain MRI methods will be applied to stroke patients,...

Quantitative Magnetic Resonance Imaging of Pulmonary Edema: Application in Acute Heart Failure

2018/19-2020/21 • $377,591 • PI,CO
Heart failure (HF) affects over half a million Canadians and growing. Acute HF is a leading cause of hospitalization (>65 years) and 20-30% of these patients die with 6 months, with a cost of billions of dollars a year. Cardiogenic pulmonary edema (water in the lungs) is a key symptom of HF (a...

MOIST study: Multi-Organ Imaging with Serial Testing in COVID-19 infected patients

2020/21 • $342,369 • PI,CO
The novel coronavirus has devastated the world since its initial outbreak in Wuhan, China in December 2019. Many individuals with this illness suffer from severe respiratory disease however there is growing evidence that this virus also affects other organs. Many patients with coronavirus...

Remission of diabetes and improved diastolic function by combining structured exercise with meal replacement and food reintroducTion (Reset) Thomas Yates

2020/21 • $165,645 • PI,CO
Eating more than we need and not being physically active enough can lead to a form of diabetes called type 2 diabetes (T2D). Now we have evidence that in people with T2D, with a very strict and strong approach to reducing how much we eat, we can even reverse T2D in some people. The approach...

The Caloric Restriction and Exercise protection from Anthracycline Toxic Effects (CREATE) study

2019/20-2020/21 • $72,917 • Scholarship/Fellowship,Other
Anthracyclines are chemotherapy agents that are commonly used to treat breast cancer. Although these treatments work well against the tumor, they are known to cause damage to the heart muscle cells and may also damage the blood vessels and skeletal muscles. These anthracycline side effects...

Cryobiology and Preservation of Cells and Tissues

2014/15-2018/19 • $604,466 • PI,CO
Cryobiology is the study of the effects of extremely low temperatures on biological systems. A major application is the low-temperature storage (cryopreservation) of cells and tissues for transplantation to treat injury and disease. While many cell types have been successfully cryopreserved and...

Imaging Diffuse Fibrosis in Acute Myocardial Infarction

2014/15-2018/19 • $462,429 • PI,CO
Acute myocardial infarction (heart attack) remains the number one cause of death and reduced quality of life of all heart diseases. The number of heart attack survivors is increasing, but the factors that determine how the heart will heal after the heart attack are not well known. Some...

Magnetic Resonance Imaging Quantification of the Toxic Effects of Chemotherapy and Protective Effects of Lifestyle Intervention on Cardiovascular and Skeletal Muscle Function in Breast Cancer

2015/16-2018/19 • $165,000 • Scholarship/Fellowship,Other
Cardiovascular disease and cancer are the top causes of death in Canadian women. Women who have had a breast cancer diagnosis are more likely to die of cardiovascular disease than women who have not had cancer. This is likely due, in part, to the damaging effects of treatment for breast cancer...

Intraspinal Neural Prosthesis for Restoring Function after Spinal Cord Injury

2013/14-2017/18 • $744,396 • PI,CO
We will develop and test a miniature implant that can electrically stimulate the spinal cord after paralysis so that standing and walking can be restored. The implant will be composed of very fine wires, smaller than the human hair that can be placed within the spinal cord in a region below the...

Bone-Seeking Iron Oxide Nanoparticles for Imaging Bone Metabolism

2016/17 • $160,000 • PI,CO
Diagnosing metabolic bone disease at an early stage plays a vital role in the success of treatment and management of diseases such as Osteoporosis, Paget's disease, Osteoarthritis, and the accurate diagnosis of overuse bone shin splints, or even metastatic bone cancers. Bone turnover is...

Prevention of Pressure Ulcer Formation using Intermittent Electrical Stimulation

2012/13-2015/16 • $459,602 • PI,CO
Pressure ulcers, also known as bed or pressure sores, are serious lesions of the skin, fat and muscle that are common in people who are unable to move on their own. They often develop in people with spinal cord injury, in the elderly, people in coma or even people who undergo long surgeries....

Multidisciplinary Approach to Novel Therapies in Cardiology-Oncology REsearch

2010/11-2013/14 • $336,627 • PI,CO
A growing number of women are diagnosed with breast cancer each year and it is one of the most common causes of death. A new chemotherapy drug called trastuzumab has been shown to decrease the risk of cancer recurrence and improve patient survival. Unfortunately, this breast cancer treatment may...

Early phase clinical trials with the small molecule DCA in Pulmonary Arterial Hypertension

2012/13-2013/14 • $290,176 • PI,CO
Pulmonary hypertension is a deadly disease with unknown cause that kills patients within 3 years from the time of diagnosis if untreated. Available therapies improve the quality of life and alleviate some symptoms but they do not appear to prolong life and they do not reverse the disease. The...

Imaging the Mechanisms of Diastolic Dysfunction and its Role in Cardiovascular Performance

2010/11-2013/14 • $281,098 • PI,CO
Heart failure is a modern day epidemic, affecting 1.5-2% of Canadians with $3 billion in hospital costs annually, and the burden will double in the next 1-2 decades. One-third of patients will die within one year of diagnosis, and all patients have a low quality of life. Surprisingly, up to half...

Cryobiology and Preservation of Cells and Tissues

2013/14 • $100,000 • PI,CO
Cryobiology is the study of the effects of extremely low temperatures on biological systems. A major application is the low-temperature storage (cryopreservation) of cells and tissues for transplantation to treat injury and disease, and for research. While many cell types have been successfully...

Thermodynamics in Cryobiology and Applications in Biopreservation

2010/11-2011/12 • $181,158 • PI,CO
Cryobiology is the study of the effects of extremely low temperatures on biological systems, with a major application being the storage of cells and tissues for research and transplantation to treat injury and disease. Cryopreservation is currently the only method available to preserve long-term...

Cryobiology and Preservation of Cells and Tissues

2011/12 • $100,000 • PI,CO
Cryobiology is the study of the effects of extremely low temperatures on biological systems, with a major application being the storage of cells and tissues for research and transplantation to treat injury and disease. While many cell types have been successfully cryopreserved clinically for...

Long-term cardiovascular and respiratory outcomes of extreme prematurity: halting the developmental origins of adult diseases.

2011/12 • $10,000 • PI,CO
Our goal is to understand how the lungs and heart of babies born too early (extreme premature infants) function later in life. This is important because 10% of children are born prematurely. More and more premature babies are now surviving, even those born as early as 16 weeks before the due...

Patents