Serge Rossignol

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Recent Research Projects

Shifting the paradigm of spinal cord quantitative MRI

2015/16-2019/20 • $547,788 • PI,Other
Pathologies of the spinal cord (SC) affect more than 200,000 Canadians and can induce severe motor, sensory and autonomic functional disability depending on the exact localisation of the lesion. Novel biomarkers based on quantitative magnetic resonance imaging (qMRI) have shown great potential...

Adaptive Mechanisms of Locomotion after Contusive Spinal Lesions in Cats

2013/14-2018/19 • $1,036,020 • PI,CO
We have previously shown that cats can recover the ability to walk with the hindlimbs 2-3 weeks after a complete surgical spinal cord injury (SCI) performed at the last Thoracic spinal segment. This confirms that there exists a complex spinal circuitry capable of generating the locomotor pattern...

Neurological SensoriMotor Rehabilitation : a multi-centric interdisciplinary Translational Research Group

2010/11-2015/16 • $2,497,255 • PI
Spinal cord injuries (SCI) after car accidents or others as well as stroke can have devastating effects on the lives of the individuals because the damages of the brain or spinal cord destroy parts of the central nervous system (CNS) essential to the control of movements such as walking. The...

Canada Research Chair on the Spinal Cord

2010/11-2014/15 • $950,000 • PI
This chair is devoted to the study of spinal cord mechanisms involved in the recovery of locomotion after spinal cord injury. Major achievements include the identification of adaptive mechanisms within the spinal cord itself as well as the localization of crucial spinal segments for the...

Adaptive mechanisms of spinal locomotion

2010/11-2013/14 • $611,750 • PI
Several sensory and motor deficits result from spinal lesions. However, in most species, including humans, motor functions such as locomotion can recover to some degree depending on the severity of the spinal lesion. Various mechanisms may account for this recovery. Undamaged fiber tracts from...

Role of compensatory mechanisms in locomotor recovery and spinal plasticity after partial spinal cord injury : dual spinal and cortical lesion paradigm

2012/13-2013/14 • $76,667 • Scholarship/Fellowship,Other
In North America, more than 250,000 people live with a spinal cord injury (SCI), and more than 10,000 new cases arise every year. For SCI patients, severe limits of such basic capacities as walking and controlling posture are a fact of life, and a crucial goal for the scientists is to find...

Multidisciplinary approach to promote and evaluate locomotion after spinal cord lesions and stroke

2010/11 • $150,000 • PI,CO
Following a spinal cord lesion or stroke which damages various structures in the central nervous system, the remaining intact structures are modified to regain some of the loss function. Our general hypothesis is that the recovery of functional locomotor capacity after such lesions can be...



The invention relates to a device for measuring the activity of the spinal cord of a vertebra, characterized in that the device comprises at least one main probe (1) shaped so as to be attached to a spinous process (2) of a vertebra (3) and to maintain in position, on either side of the vertebra, at least one transmitter (6) for transmitting a wave capable of interaction with the spinal cord (7) and at least one associated receiver (8) for receiving the wave that interacted with the spinal...
Related applications: CA20102780509, WO2010EP06832, EP20100779707