Molly S. Shoichet

Contact via University of Toronto

Key Research Areas
Associated Researchers
Associated Organizations

Recent Research Projects

Polymeric Biomaterials for Applications in Medicine

2015/16-2020/21 • $2,263,895 • PI,Other
Overarching Direction of Research ProgramTo design biomaterials solutions to unsolved problems in medicine. To influence cell fate through local and targeted delivery strategies and engineered three-dimensional (3D) hydrogel microenvironments. We will design novel injectable hydrogels for local...

Engineering healing: Combinatorial strategies to promote repair of the stroke injured brain

2020/21 • $203,080 • PI,Other
In Canada, it is estimated that stroke costs the Canadian economy almost $3 billion per year. Stem cell based therapies hold great promise for the treatment of stroke. This research will lay the foundation for clinical approaches to treat stroke by addressing current challenges with cell based...

Improving photoreceptor survival through local delivery of neuroprotective factors and cells to the retina

2020/21 • $50,000 • Scholarship/Fellowship,Other
Age-related macular degeneration is the leading cause of blindness in the developed world. However, there is currently no cure for vision loss once the photoreceptor cells have degenerated. Drug treatments or surgical interventions are effective at slowing the disease progression, though...

Treating inherited blinding disease with a slow released form of the rod-derived cone viability factor protein

2020/21 • $12,500 • PI
Vision relies on two types of photoreceptors in the retina at the back of the eye: rod photoreceptors, which are responsible for night vision, and cone photoreceptors, which are responsible for daylight vision. Rods and cones have an intimate relationship, with rod photoreceptors producing a...

Promoting neural regeneration with stem cell based therapies: A novel source of autologous human neural stem cells for transplantation

2014/15-2018/19 • $1,250,000 • PI,CO
While the promise of stem cells is real, the reality of stem cell based therapies is limited by an incomplete understanding of the multitude of interactions required for successful transplantation therapies. The most significant challenge is identifying the ideal cell type that should be...

Promoting cognitive recovery using endogenous neural stem cell activation and rehabilitation following stroke

2012/13-2017/18 • $992,394 • PI,CO
Stroke is the leading cause of permanent neurological disability in Canada with over 50,000 new cases annually. There are no current medical therapies for alleviating the chronic functional impairments following stroke. The identification of multipotent neural stem cells in the adult mammalian...

Brain Cancer Treatment: innovations in delivery of stable siRNAs and chemotherapeutics

2015/16-2017/18 • $504,350 • PI,CO
Brain cancer is largely incurable and mostly untreatable. The most common form of brain cancer, malignant gliomas, are very aggressive, resulting in patient survival of only a year after diagnosis. Present treatments for malignant gliomas largely fail because cancer cells can rapidly invade...

Design of a high content personalized medicine screening tool for the treatment of cancer

2013/14-2015/16 • $479,799 • PI,CO,Other
Drug treatments for cancer patients are largely based on the part of the body where the cancer originated and its appearance under the microscope. New personalized treatment approaches are needed to improve survival and reduce the side effects of ineffective treatments. Our goal is to design a...

Local Delivery of Therapeutic Biomolecules to the Injured Spinal Cord

2012/13-2015/16 • $411,821 • PI,CO
Traumatic spinal cord injury is devastating. It comes without warning to our most physically active youth. There is no cure for spinal cord injury, and only limited surgical interventions are available. There are some biomolecules that have generated significant excitement in the community, but...

Enhancement of nerve regeneration with controlled release of neurotrophic factors

2013/14-2015/16 • $220,356 • PI
Nerve injury produces lifelong disability in many patients. Despite the best current surgical methods, clinical results remain suboptimal. We have previously demonstrated, delivery of growth factors improves functional outcomes in rats with severe peripheral nerve injuries. We now propose using...

CIHR Training Program in Regenerative Medicine

2010/11-2014/15 • $1,625,000 • PI,CO
Organ failure is a pervasive medical problem that results in immense personal and economic costs, morbidity, and death. At present, the only truly effective treatment for organ failure is transplantation. The deficiencies of this option are increasingly apparent, and include a chronic shortage...

Polymeric Nanospheres Designed for Targeted Delivery in Breast Cancer

2010/11-2014/15 • $586,822 • PI,CO
Breast cancer affects 1 million women worldwide and is the leading cause of death among women due to cancer. Of these women, 20-30% of them will have the most deadly of breast cancers, where the breast cancer cells express the human epidermal growth factor receptor, HER2. These HER2-positive...

Bioengineered cell delivery system

2011/12-2013/14 • $344,130 • PI,CO
Traumatic spinal cord injury is often described in terms of the primary injury, which results from a mechanical insult such as a motor vehicle or sports-related accident, and the secondary injury, which results in a cascade of events, resulting in an inhibitory environment. The latter limits...

Minimally-invasive Drug Delivery Strategy for Acute Spinal Cord Injury Repair

2010/11-2012/13 • $322,527 • PI,CO
After traumatic spinal cord injury, the communication pathway between the brain and the rest of the body (the periphery) deteriorates, resulting in essentially lost function below the site of injury. To promote communication between the brain and the periphery after injury, we are developing a...

Enhancing the integration of stem cells and their progeny after transplantation into degenerating retina.

2011/12-2012/13 • $55,000 • Scholarship/Fellowship,Other
Diseases of vision affect the entire Canadian age spectrum, from newborns to our senior population. With our growing and aging population, it is expected that the cases of age-related vision loss will rise. Two major groups of diseases, retinitis pigmentosa (affecting children and teenagers) and...

Commercial Development of Bioengineered Therapeutic Strategy for Spinal Cord Injury

2010/11-2011/12 • $159,996 • PI
Individuals with spinal cord injury (SCI) are faced with great emotional, social and financial challenges, and an impaired quality of life due to loss of motor, sensory and autonomic function. With over 1 million patients suffering from chronic spinal cord injury and no effective therapy, the...